Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129935323> ?p ?o ?g. }
- W3129935323 endingPage "2456" @default.
- W3129935323 startingPage "2442" @default.
- W3129935323 abstract "The TP53-R337H founder mutation exists at a high frequency throughout southern Brazil and represents one of the most common germline TP53 mutations reported to date. It was identified in pediatric adrenocortical tumors in families with a low incidence of cancer. The R337H mutation has since been found in association with early-onset breast cancers and Li-Fraumeni syndrome (LFS). To study this variability in tumor susceptibility, we generated a knockin mutant p53 mouse model (R334H). Endogenous murine p53-R334H protein was naturally expressed at high levels in multiple tissues and was functionally compromised in a tissue- and stress-specific manner. Mutant p53-R334H mice developed tumors with long latency and incomplete penetrance, consistent with many human carriers being at a low but elevated risk for cancer. These findings suggest the involvement of additional cooperating genetic alterations when TP53-R337H occurs in the context of LFS, which has important implications for genetic counseling and long-term clinical follow-up. SIGNIFICANCE: A p53-R334H knockin mouse serves as an important model for studying the most common inherited germline TP53 mutation (R337H) that is associated with variable tumor susceptibility." @default.
- W3129935323 created "2021-03-01" @default.
- W3129935323 creator A5001478843 @default.
- W3129935323 creator A5006487701 @default.
- W3129935323 creator A5006819204 @default.
- W3129935323 creator A5015937810 @default.
- W3129935323 creator A5030630722 @default.
- W3129935323 creator A5033416022 @default.
- W3129935323 creator A5045816572 @default.
- W3129935323 creator A5046880941 @default.
- W3129935323 creator A5053244337 @default.
- W3129935323 creator A5059960472 @default.
- W3129935323 creator A5064611054 @default.
- W3129935323 creator A5070426242 @default.
- W3129935323 creator A5075849954 @default.
- W3129935323 creator A5076622040 @default.
- W3129935323 creator A5084238877 @default.
- W3129935323 creator A5086250633 @default.
- W3129935323 date "2021-02-26" @default.
- W3129935323 modified "2023-09-30" @default.
- W3129935323 title "The Common Germline <i>TP53-R337H</i> Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model" @default.
- W3129935323 cites W1938299812 @default.
- W3129935323 cites W1941400403 @default.
- W3129935323 cites W1964719993 @default.
- W3129935323 cites W1968075576 @default.
- W3129935323 cites W1969044026 @default.
- W3129935323 cites W1970399383 @default.
- W3129935323 cites W1973886069 @default.
- W3129935323 cites W1981178222 @default.
- W3129935323 cites W1987912339 @default.
- W3129935323 cites W1996899753 @default.
- W3129935323 cites W2002993576 @default.
- W3129935323 cites W2005542290 @default.
- W3129935323 cites W2034882416 @default.
- W3129935323 cites W2040263713 @default.
- W3129935323 cites W2046958356 @default.
- W3129935323 cites W2049970248 @default.
- W3129935323 cites W2056079046 @default.
- W3129935323 cites W2067107606 @default.
- W3129935323 cites W2072268909 @default.
- W3129935323 cites W2075676198 @default.
- W3129935323 cites W2078581194 @default.
- W3129935323 cites W2079852484 @default.
- W3129935323 cites W2088740611 @default.
- W3129935323 cites W2090940786 @default.
- W3129935323 cites W2095370504 @default.
- W3129935323 cites W2098098349 @default.
- W3129935323 cites W2107277218 @default.
- W3129935323 cites W2108158811 @default.
- W3129935323 cites W2120961400 @default.
- W3129935323 cites W2130311916 @default.
- W3129935323 cites W2130410032 @default.
- W3129935323 cites W2132195353 @default.
- W3129935323 cites W2133959309 @default.
- W3129935323 cites W2137003359 @default.
- W3129935323 cites W2137302959 @default.
- W3129935323 cites W2143728695 @default.
- W3129935323 cites W2149645123 @default.
- W3129935323 cites W2150608281 @default.
- W3129935323 cites W2159202225 @default.
- W3129935323 cites W2162723956 @default.
- W3129935323 cites W2164559478 @default.
- W3129935323 cites W2167491180 @default.
- W3129935323 cites W2170989872 @default.
- W3129935323 cites W2192080449 @default.
- W3129935323 cites W2196516240 @default.
- W3129935323 cites W2214074259 @default.
- W3129935323 cites W2324248025 @default.
- W3129935323 cites W2414230171 @default.
- W3129935323 cites W2472035483 @default.
- W3129935323 cites W2522875401 @default.
- W3129935323 cites W2810803965 @default.
- W3129935323 cites W2883477549 @default.
- W3129935323 cites W3037439237 @default.
- W3129935323 doi "https://doi.org/10.1158/0008-5472.can-20-1750" @default.
- W3129935323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8137600" @default.
- W3129935323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33637564" @default.
- W3129935323 hasPublicationYear "2021" @default.
- W3129935323 type Work @default.
- W3129935323 sameAs 3129935323 @default.
- W3129935323 citedByCount "5" @default.
- W3129935323 countsByYear W31299353232022 @default.
- W3129935323 countsByYear W31299353232023 @default.
- W3129935323 crossrefType "journal-article" @default.
- W3129935323 hasAuthorship W3129935323A5001478843 @default.
- W3129935323 hasAuthorship W3129935323A5006487701 @default.
- W3129935323 hasAuthorship W3129935323A5006819204 @default.
- W3129935323 hasAuthorship W3129935323A5015937810 @default.
- W3129935323 hasAuthorship W3129935323A5030630722 @default.
- W3129935323 hasAuthorship W3129935323A5033416022 @default.
- W3129935323 hasAuthorship W3129935323A5045816572 @default.
- W3129935323 hasAuthorship W3129935323A5046880941 @default.
- W3129935323 hasAuthorship W3129935323A5053244337 @default.
- W3129935323 hasAuthorship W3129935323A5059960472 @default.
- W3129935323 hasAuthorship W3129935323A5064611054 @default.
- W3129935323 hasAuthorship W3129935323A5070426242 @default.
- W3129935323 hasAuthorship W3129935323A5075849954 @default.
- W3129935323 hasAuthorship W3129935323A5076622040 @default.