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- W3129961448 endingPage "1076" @default.
- W3129961448 startingPage "1076" @default.
- W3129961448 abstract "Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins that are frequently overexpressed in many cancers. As a result, these receptor families constitute attractive targets for imaging and therapeutic applications in the detection and treatment of cancer. This review explores the dynamic structure and structure-function relationships of these two growth factor receptors and their significance as it relates to theranostics of cancer, followed by some of the common inhibition modalities frequently employed to target EGFR and VEGFR, such as tyrosine kinase inhibitors (TKIs), antibodies, nanobodies, and peptides. A summary of the recent advances in molecular imaging techniques, including positron emission tomography (PET), single-photon emission computerized tomography (SPECT), computed tomography (CT), magnetic resonance imaging (MRI), and optical imaging (OI), and in particular, near-IR fluorescence imaging using tetrapyrrolic-based fluorophores, concludes this review." @default.
- W3129961448 created "2021-03-01" @default.
- W3129961448 creator A5023212203 @default.
- W3129961448 creator A5039214727 @default.
- W3129961448 creator A5043937178 @default.
- W3129961448 creator A5059975396 @default.
- W3129961448 date "2021-02-18" @default.
- W3129961448 modified "2023-10-18" @default.
- W3129961448 title "Molecular Targeting of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR)" @default.
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