FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3129986891> ?p ?o ?g. }

• W3129986891 endingPage "224" @default.
• W3129986891 startingPage "213" @default.
• W3129986891 abstract "Thyroid carcinoma incidence rates in western societies are among the fastest rising, compared to all malignant tumors over the past two decades. While risk factors such as age and exposure to ionizing radiation are known, early-state carcinogenic processes or pre-lesions are poorly understood or unknown. This study aims at the identification and characterization of early-state radiation-associated neoplastic processes by histologic and transcriptomic analyses of thyroid tissues derived from a mouse model. Comprehensive histological examination of 246 thyroids (164 exposed, 82 non-exposed) was carried out. Proliferative and normal tissues from exposed cases and normal tissue from non-exposed cases were collected by laser-capture microdissection, followed by RNAseq transcriptomic profiling using a low input 3'-library preparation protocol, differential gene expression analysis and functional association by gene set enrichment analysis. Nine exposed samples exhibited proliferative lesions, while none of the non-exposed samples showed histological abnormalities, indicating an association of ionizing radiation exposure with histological abnormalities. Activated immune response signaling and deregulated metabolic processes were observed in irradiated tissue with normal histology compared to normal tissue from non-exposed samples. Proliferative lesions compared to corresponding normal tissues showed enrichment for mainly proliferation-associated gene sets. Consistently, proliferative lesion samples from exposed mice showed elevated proliferation-associated signaling and deregulated metabolic processes compared to normal samples from non-exposed mice. Our findings suggest that a molecular deregulation may be detectable in histologically normal thyroid tissues and in early proliferative lesions in the frame of multi-step progression from irradiated normal tissue to tumorous lesions." @default.
• W3129986891 created "2021-03-01" @default.
• W3129986891 creator A5011742516 @default.
• W3129986891 creator A5016924764 @default.
• W3129986891 creator A5030015197 @default.
• W3129986891 creator A5034232228 @default.
• W3129986891 creator A5036123395 @default.
• W3129986891 creator A5050705404 @default.
• W3129986891 creator A5052307289 @default.
• W3129986891 creator A5052400362 @default.
• W3129986891 creator A5074211261 @default.
• W3129986891 creator A5083313241 @default.
• W3129986891 creator A5086970985 @default.
• W3129986891 creator A5090323490 @default.
• W3129986891 date "2021-03-01" @default.
• W3129986891 modified "2023-10-16" @default.
• W3129986891 title "Transcriptomic landscape of radiation-induced murine thyroid proliferative lesions" @default.
• W3129986891 cites W1966633789 @default.
• W3129986891 cites W1993980834 @default.
• W3129986891 cites W1997507460 @default.
• W3129986891 cites W2031628470 @default.
• W3129986891 cites W2051278269 @default.
• W3129986891 cites W2052097990 @default.
• W3129986891 cites W2088001765 @default.
• W3129986891 cites W2101981161 @default.
• W3129986891 cites W2111474003 @default.
• W3129986891 cites W2118986295 @default.
• W3129986891 cites W2129363220 @default.
• W3129986891 cites W2138207763 @default.
• W3129986891 cites W2149411458 @default.
• W3129986891 cites W2204695746 @default.
• W3129986891 cites W2281172928 @default.
• W3129986891 cites W2344533005 @default.
• W3129986891 cites W2431013324 @default.
• W3129986891 cites W2472544934 @default.
• W3129986891 cites W2548265008 @default.
• W3129986891 cites W2726433034 @default.
• W3129986891 cites W2769592305 @default.
• W3129986891 cites W2771157336 @default.
• W3129986891 cites W2898717674 @default.
• W3129986891 cites W2902964443 @default.
• W3129986891 cites W2965558747 @default.
• W3129986891 cites W3005392003 @default.
• W3129986891 doi "https://doi.org/10.1530/erc-21-0019" @default.
• W3129986891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33608487" @default.
• W3129986891 hasPublicationYear "2021" @default.
• W3129986891 type Work @default.
• W3129986891 sameAs 3129986891 @default.
• W3129986891 citedByCount "0" @default.
• W3129986891 crossrefType "journal-article" @default.
• W3129986891 hasAuthorship W3129986891A5011742516 @default.
• W3129986891 hasAuthorship W3129986891A5016924764 @default.
• W3129986891 hasAuthorship W3129986891A5030015197 @default.
• W3129986891 hasAuthorship W3129986891A5034232228 @default.
• W3129986891 hasAuthorship W3129986891A5036123395 @default.
• W3129986891 hasAuthorship W3129986891A5050705404 @default.
• W3129986891 hasAuthorship W3129986891A5052307289 @default.
• W3129986891 hasAuthorship W3129986891A5052400362 @default.
• W3129986891 hasAuthorship W3129986891A5074211261 @default.
• W3129986891 hasAuthorship W3129986891A5083313241 @default.
• W3129986891 hasAuthorship W3129986891A5086970985 @default.
• W3129986891 hasAuthorship W3129986891A5090323490 @default.
• W3129986891 hasConcept C104317684 @default.
• W3129986891 hasConcept C125965507 @default.
• W3129986891 hasConcept C134018914 @default.
• W3129986891 hasConcept C142724271 @default.
• W3129986891 hasConcept C150194340 @default.
• W3129986891 hasConcept C162317418 @default.
• W3129986891 hasConcept C502942594 @default.
• W3129986891 hasConcept C526584372 @default.
• W3129986891 hasConcept C54355233 @default.
• W3129986891 hasConcept C57742111 @default.
• W3129986891 hasConcept C71924100 @default.
• W3129986891 hasConcept C86803240 @default.
• W3129986891 hasConceptScore W3129986891C104317684 @default.
• W3129986891 hasConceptScore W3129986891C125965507 @default.
• W3129986891 hasConceptScore W3129986891C134018914 @default.
• W3129986891 hasConceptScore W3129986891C142724271 @default.
• W3129986891 hasConceptScore W3129986891C150194340 @default.
• W3129986891 hasConceptScore W3129986891C162317418 @default.
• W3129986891 hasConceptScore W3129986891C502942594 @default.
• W3129986891 hasConceptScore W3129986891C526584372 @default.
• W3129986891 hasConceptScore W3129986891C54355233 @default.
• W3129986891 hasConceptScore W3129986891C57742111 @default.
• W3129986891 hasConceptScore W3129986891C71924100 @default.
• W3129986891 hasConceptScore W3129986891C86803240 @default.
• W3129986891 hasIssue "3" @default.
• W3129986891 hasLocation W31299868911 @default.
• W3129986891 hasLocation W31299868912 @default.
• W3129986891 hasOpenAccess W3129986891 @default.
• W3129986891 hasPrimaryLocation W31299868911 @default.
• W3129986891 hasRelatedWork W1264215788 @default.
• W3129986891 hasRelatedWork W2054938974 @default.
• W3129986891 hasRelatedWork W2143095603 @default.
• W3129986891 hasRelatedWork W2171928393 @default.
• W3129986891 hasRelatedWork W2891999177 @default.
• W3129986891 hasRelatedWork W2919381586 @default.
• W3129986891 hasRelatedWork W2949097641 @default.

• next