FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130147112> ?p ?o ?g. }

• W3130147112 abstract "We aimed to explore the tumor mutational burden (TMB) and immune infiltration in HCC and investigate new biomarkers for immunotherapy. Transcriptome and gene mutation data were downloaded from the GDC portal, including 374 HCC samples and 50 matched normal samples. Furthermore, we divided the samples into high and low TMB groups, and analyzed the differential genes between them with GO, KEGG, and GSEA. Cibersort was used to assess the immune cell infiltration in the samples. Finally, univariate and multivariate Cox regression analyses were performed to identify differential genes related to TMB and immune infiltration, and a risk prediction model was constructed. We found 10 frequently mutated genes, including TP53, TTN, CTNNB1, MUC16, ALB, PCLO, MUC, APOB, RYR2, and ABCA. Pathway analysis indicated that these TMB-related differential genes were mainly enriched in PI3K-AKT. Cibersort analysis showed that memory B cells ( p = 0.02), CD8+ T cells ( p = 0.09), CD4+ memory activated T cells ( p = 0.07), and neutrophils ( p = 0.06) demonstrated a difference in immune infiltration between high and low TMB groups. On multivariate analysis, GABRA3 ( p = 0.05), CECR7 ( p &lt; 0.001), TRIM16 ( p = 0.003), and IL7R ( p = 0.04) were associated with TMB and immune infiltration. The risk prediction model had an area under the curve (AUC) of 0.69, suggesting that patients with low risk had better survival outcomes. Our study demonstrated for the first time that CECR7, GABRA3, IL7R, and TRIM16L were associated with TMB and promoted antitumor immunity in HCC." @default.
• W3130147112 created "2021-03-01" @default.
• W3130147112 creator A5012405909 @default.
• W3130147112 creator A5053110985 @default.
• W3130147112 creator A5083532124 @default.
• W3130147112 date "2021-02-16" @default.
• W3130147112 modified "2023-10-18" @default.
• W3130147112 title "Identification of Tumor Mutation Burden and Immune Infiltrates in Hepatocellular Carcinoma Based on Multi-Omics Analysis" @default.
• W3130147112 cites W1757407923 @default.
• W3130147112 cites W1985987855 @default.
• W3130147112 cites W2018851752 @default.
• W3130147112 cites W2023485136 @default.
• W3130147112 cites W2130410032 @default.
• W3130147112 cites W2137052325 @default.
• W3130147112 cites W2155943701 @default.
• W3130147112 cites W2166662937 @default.
• W3130147112 cites W2194546364 @default.
• W3130147112 cites W2235523093 @default.
• W3130147112 cites W2341369626 @default.
• W3130147112 cites W2530417471 @default.
• W3130147112 cites W2605233023 @default.
• W3130147112 cites W2617615447 @default.
• W3130147112 cites W2630396004 @default.
• W3130147112 cites W2751681739 @default.
• W3130147112 cites W2765232121 @default.
• W3130147112 cites W2799508518 @default.
• W3130147112 cites W2888270102 @default.
• W3130147112 cites W2890298773 @default.
• W3130147112 cites W2898929429 @default.
• W3130147112 cites W2900082702 @default.
• W3130147112 cites W2911335821 @default.
• W3130147112 cites W2918019324 @default.
• W3130147112 cites W2944817662 @default.
• W3130147112 cites W2946272661 @default.
• W3130147112 cites W2946603276 @default.
• W3130147112 cites W2948438687 @default.
• W3130147112 cites W2969802526 @default.
• W3130147112 cites W2979453720 @default.
• W3130147112 cites W3000074215 @default.
• W3130147112 cites W3000401463 @default.
• W3130147112 cites W3004518290 @default.
• W3130147112 cites W3015205417 @default.
• W3130147112 cites W3044807957 @default.
• W3130147112 cites W4211183069 @default.
• W3130147112 cites W4245703674 @default.
• W3130147112 doi "https://doi.org/10.3389/fmolb.2020.599142" @default.
• W3130147112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7928364" @default.
• W3130147112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33681288" @default.
• W3130147112 hasPublicationYear "2021" @default.
• W3130147112 type Work @default.
• W3130147112 sameAs 3130147112 @default.
• W3130147112 citedByCount "17" @default.
• W3130147112 countsByYear W31301471122021 @default.
• W3130147112 countsByYear W31301471122022 @default.
• W3130147112 countsByYear W31301471122023 @default.
• W3130147112 crossrefType "journal-article" @default.
• W3130147112 hasAuthorship W3130147112A5012405909 @default.
• W3130147112 hasAuthorship W3130147112A5053110985 @default.
• W3130147112 hasAuthorship W3130147112A5083532124 @default.
• W3130147112 hasBestOaLocation W31301471121 @default.
• W3130147112 hasConcept C104317684 @default.
• W3130147112 hasConcept C10515644 @default.
• W3130147112 hasConcept C121332964 @default.
• W3130147112 hasConcept C126322002 @default.
• W3130147112 hasConcept C143998085 @default.
• W3130147112 hasConcept C144301174 @default.
• W3130147112 hasConcept C150194340 @default.
• W3130147112 hasConcept C152724338 @default.
• W3130147112 hasConcept C153400128 @default.
• W3130147112 hasConcept C162317418 @default.
• W3130147112 hasConcept C167672396 @default.
• W3130147112 hasConcept C203014093 @default.
• W3130147112 hasConcept C2777701055 @default.
• W3130147112 hasConcept C2778019345 @default.
• W3130147112 hasConcept C38180746 @default.
• W3130147112 hasConcept C502942594 @default.
• W3130147112 hasConcept C50382708 @default.
• W3130147112 hasConcept C54355233 @default.
• W3130147112 hasConcept C71924100 @default.
• W3130147112 hasConcept C86803240 @default.
• W3130147112 hasConcept C8891405 @default.
• W3130147112 hasConcept C97355855 @default.
• W3130147112 hasConceptScore W3130147112C104317684 @default.
• W3130147112 hasConceptScore W3130147112C10515644 @default.
• W3130147112 hasConceptScore W3130147112C121332964 @default.
• W3130147112 hasConceptScore W3130147112C126322002 @default.
• W3130147112 hasConceptScore W3130147112C143998085 @default.
• W3130147112 hasConceptScore W3130147112C144301174 @default.
• W3130147112 hasConceptScore W3130147112C150194340 @default.
• W3130147112 hasConceptScore W3130147112C152724338 @default.
• W3130147112 hasConceptScore W3130147112C153400128 @default.
• W3130147112 hasConceptScore W3130147112C162317418 @default.
• W3130147112 hasConceptScore W3130147112C167672396 @default.
• W3130147112 hasConceptScore W3130147112C203014093 @default.
• W3130147112 hasConceptScore W3130147112C2777701055 @default.
• W3130147112 hasConceptScore W3130147112C2778019345 @default.
• W3130147112 hasConceptScore W3130147112C38180746 @default.
• W3130147112 hasConceptScore W3130147112C502942594 @default.
• W3130147112 hasConceptScore W3130147112C50382708 @default.
• W3130147112 hasConceptScore W3130147112C54355233 @default.

• next