Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130148612> ?p ?o ?g. }
- W3130148612 endingPage "547" @default.
- W3130148612 startingPage "535" @default.
- W3130148612 abstract "Cerebral malaria (CM) is the most severe complication caused by Plasmodium falciparum infection. The pathophysiological changes caused by parasite virulence factors and the human immune response to parasites contribute to CM. To date, very few parasite virulence proteins have been found to participate in CM. Here, we employed comparative genomics analysis and identified parasite-infected erythrocyte specific protein 2 (PIESP2) to be a CM-related protein. We conducted further experimental investigations and found that PIESP2 is an immunogenic protein. PIESP2 expression begins at the early trophozoite stage and progressively increases with parasite development. Although PIESP2 proteins mainly reside within infected red blood cells (IRBCs), some of them are present on the IRBC surface at the pigmented stage. Moreover, blockage of PIESP2 by antiserum apparently inhibited the adhesion of IRBCs to brain microvascular endothelial cells (BMECs). Western blot analysis detected the binding of PIESP2 to BMECs. Transcriptional analysis revealed that the binding of PIESP2 to BMECs can increase the expression of genes involved in the inflammatory response but decrease the expression of genes related to the anchoring junction. Overall, PIESP2 might be associated with CM by mediating the sequestration of IRBCs, inducing the inflammation response, and impairing the integrity of blood–brain barrier." @default.
- W3130148612 created "2021-03-01" @default.
- W3130148612 creator A5025441749 @default.
- W3130148612 creator A5032646663 @default.
- W3130148612 creator A5042241049 @default.
- W3130148612 creator A5046056648 @default.
- W3130148612 creator A5048918491 @default.
- W3130148612 creator A5066602086 @default.
- W3130148612 creator A5075877548 @default.
- W3130148612 creator A5080687802 @default.
- W3130148612 date "2021-04-01" @default.
- W3130148612 modified "2023-10-11" @default.
- W3130148612 title "Identification of Plasmodium falciparum-specific protein PIESP2 as a novel virulence factor related to cerebral malaria" @default.
- W3130148612 cites W1972073650 @default.
- W3130148612 cites W1973155668 @default.
- W3130148612 cites W1973200069 @default.
- W3130148612 cites W1984347606 @default.
- W3130148612 cites W2010232364 @default.
- W3130148612 cites W2012403820 @default.
- W3130148612 cites W2013503056 @default.
- W3130148612 cites W2020755315 @default.
- W3130148612 cites W2022387905 @default.
- W3130148612 cites W2037173275 @default.
- W3130148612 cites W2039671478 @default.
- W3130148612 cites W2046575333 @default.
- W3130148612 cites W2071295015 @default.
- W3130148612 cites W2072386798 @default.
- W3130148612 cites W2090613637 @default.
- W3130148612 cites W2102155970 @default.
- W3130148612 cites W2102278945 @default.
- W3130148612 cites W2104005232 @default.
- W3130148612 cites W2111065008 @default.
- W3130148612 cites W2113251371 @default.
- W3130148612 cites W2116931446 @default.
- W3130148612 cites W2117132127 @default.
- W3130148612 cites W2121563923 @default.
- W3130148612 cites W2123179582 @default.
- W3130148612 cites W2125264382 @default.
- W3130148612 cites W2128611502 @default.
- W3130148612 cites W2130410032 @default.
- W3130148612 cites W2152770371 @default.
- W3130148612 cites W2157412455 @default.
- W3130148612 cites W2159675211 @default.
- W3130148612 cites W2224255765 @default.
- W3130148612 cites W2340443823 @default.
- W3130148612 cites W2414887958 @default.
- W3130148612 cites W2568630644 @default.
- W3130148612 cites W2609207099 @default.
- W3130148612 cites W2624256924 @default.
- W3130148612 cites W2766181748 @default.
- W3130148612 cites W2804973392 @default.
- W3130148612 cites W2888356961 @default.
- W3130148612 cites W2906262892 @default.
- W3130148612 cites W2954291228 @default.
- W3130148612 cites W3012259093 @default.
- W3130148612 cites W4236042401 @default.
- W3130148612 doi "https://doi.org/10.1016/j.ijbiomac.2021.02.145" @default.
- W3130148612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33631268" @default.
- W3130148612 hasPublicationYear "2021" @default.
- W3130148612 type Work @default.
- W3130148612 sameAs 3130148612 @default.
- W3130148612 citedByCount "4" @default.
- W3130148612 countsByYear W31301486122021 @default.
- W3130148612 countsByYear W31301486122022 @default.
- W3130148612 countsByYear W31301486122023 @default.
- W3130148612 crossrefType "journal-article" @default.
- W3130148612 hasAuthorship W3130148612A5025441749 @default.
- W3130148612 hasAuthorship W3130148612A5032646663 @default.
- W3130148612 hasAuthorship W3130148612A5042241049 @default.
- W3130148612 hasAuthorship W3130148612A5046056648 @default.
- W3130148612 hasAuthorship W3130148612A5048918491 @default.
- W3130148612 hasAuthorship W3130148612A5066602086 @default.
- W3130148612 hasAuthorship W3130148612A5075877548 @default.
- W3130148612 hasAuthorship W3130148612A5080687802 @default.
- W3130148612 hasConcept C104317684 @default.
- W3130148612 hasConcept C136764020 @default.
- W3130148612 hasConcept C147483822 @default.
- W3130148612 hasConcept C159047783 @default.
- W3130148612 hasConcept C169760540 @default.
- W3130148612 hasConcept C203014093 @default.
- W3130148612 hasConcept C2776415932 @default.
- W3130148612 hasConcept C2776914184 @default.
- W3130148612 hasConcept C2778048844 @default.
- W3130148612 hasConcept C2778371730 @default.
- W3130148612 hasConcept C2778402981 @default.
- W3130148612 hasConcept C2781090273 @default.
- W3130148612 hasConcept C2908793570 @default.
- W3130148612 hasConcept C41008148 @default.
- W3130148612 hasConcept C529278444 @default.
- W3130148612 hasConcept C54355233 @default.
- W3130148612 hasConcept C60987743 @default.
- W3130148612 hasConcept C71928629 @default.
- W3130148612 hasConcept C86803240 @default.
- W3130148612 hasConcept C8891405 @default.
- W3130148612 hasConcept C89423630 @default.
- W3130148612 hasConcept C91523082 @default.
- W3130148612 hasConceptScore W3130148612C104317684 @default.
- W3130148612 hasConceptScore W3130148612C136764020 @default.