FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130207430> ?p ?o ?g. }

• W3130207430 endingPage "113940" @default.
• W3130207430 startingPage "113940" @default.
• W3130207430 abstract "Abstract Ethnopharmacological relevance Salvia species are known to have anti-inflammatory properties, and are traditionally used for healing purposes. Salvia verbenaca is an Algerian plant used for healing wounds and ulcers. Aim of the study This work aims to assess the acute and subacute safety of S. verbenaca and its possible anti-inflammatory activity as a mechanism contributing to its traditional applications. Materials and methods Lethal toxicity of S. verbenaca hydromethanolic extract was evaluated against Artemia salina larvae, while acute and subacute toxicity were orally tested on mice. The anti-inflammatory activity was screened ex vivo using membrane stabilization and in vivo using xylene induced ear edema as an acute inflammation model. The antiradical, reducing power and iron chelating activities of S. verbenaca were also investigated in vitro, and phenolic compounds were determined using UHPLC-DAD-ESI-MSn. Results Salvia verbenaca extract contained high amounts of phenolic compounds (206 μg GAE/mg extract). The in vitro antioxidant activity showed promising radical scavenging ability, iron chelating (IC50: 189 μg/mL), reducing power and strong anti-lipid-peroxidation effect (IC50: 111 μg/mL). The extract had potential cytotoxic effect against Artemia salina larvae (LC50: 30 μg/mL), but did not exhibit any acute/subacute toxicity effect on mice. Salvia verbenaca inhibited hypotonic and heat induced hemolysis and also reduced 50% of xylene induced ear edema at 600 mg/kg bw. Rosmarinic acid and caffeoylmalic acid were identified as the major compounds. Conclusion Salvia verbenaca hydromethanolic extract was found to be safe at acute and subacute levels. Its in vitro/in vivo antioxidant activity, membrane stabilizing properties and anti-inflammatory activity may be an important aspect of its wound healing and anti-ulcer traditional use." @default.
• W3130207430 created "2021-03-01" @default.
• W3130207430 creator A5003897678 @default.
• W3130207430 creator A5015390779 @default.
• W3130207430 creator A5028289172 @default.
• W3130207430 creator A5041011625 @default.
• W3130207430 creator A5062745812 @default.
• W3130207430 creator A5065210033 @default.
• W3130207430 creator A5073540033 @default.
• W3130207430 creator A5079123217 @default.
• W3130207430 creator A5080061299 @default.
• W3130207430 date "2021-05-01" @default.
• W3130207430 modified "2023-10-13" @default.
• W3130207430 title "Phenolic profile, safety assessment, and anti-inflammatory activity of Salvia verbenaca L." @default.
• W3130207430 cites W1174839022 @default.
• W3130207430 cites W1561098119 @default.
• W3130207430 cites W1732291667 @default.
• W3130207430 cites W1935626365 @default.
• W3130207430 cites W1968957727 @default.
• W3130207430 cites W1971580443 @default.
• W3130207430 cites W1977656346 @default.
• W3130207430 cites W2005949758 @default.
• W3130207430 cites W2017549835 @default.
• W3130207430 cites W2032183897 @default.
• W3130207430 cites W2036783607 @default.
• W3130207430 cites W2048356044 @default.
• W3130207430 cites W2053249752 @default.
• W3130207430 cites W2060457597 @default.
• W3130207430 cites W2074509460 @default.
• W3130207430 cites W2078811968 @default.
• W3130207430 cites W2081335216 @default.
• W3130207430 cites W2084751277 @default.
• W3130207430 cites W2087543087 @default.
• W3130207430 cites W2087613299 @default.
• W3130207430 cites W2089071120 @default.
• W3130207430 cites W2096945589 @default.
• W3130207430 cites W2101726573 @default.
• W3130207430 cites W2114476260 @default.
• W3130207430 cites W2130373475 @default.
• W3130207430 cites W2138205959 @default.
• W3130207430 cites W2139626257 @default.
• W3130207430 cites W2162566359 @default.
• W3130207430 cites W2164477417 @default.
• W3130207430 cites W2166220683 @default.
• W3130207430 cites W2167876137 @default.
• W3130207430 cites W2399597446 @default.
• W3130207430 cites W2425885539 @default.
• W3130207430 cites W2507502614 @default.
• W3130207430 cites W2587802024 @default.
• W3130207430 cites W2607717320 @default.
• W3130207430 cites W2609334030 @default.
• W3130207430 cites W2612250641 @default.
• W3130207430 cites W2743168127 @default.
• W3130207430 cites W2767491184 @default.
• W3130207430 cites W2768499679 @default.
• W3130207430 cites W2770773575 @default.
• W3130207430 cites W2808945464 @default.
• W3130207430 cites W2890288014 @default.
• W3130207430 cites W2893828091 @default.
• W3130207430 cites W2902641822 @default.
• W3130207430 cites W2909309490 @default.
• W3130207430 cites W2910483381 @default.
• W3130207430 cites W2966330846 @default.
• W3130207430 cites W2991081699 @default.
• W3130207430 cites W3012139570 @default.
• W3130207430 cites W3033922709 @default.
• W3130207430 cites W3037152614 @default.
• W3130207430 cites W3081994826 @default.
• W3130207430 cites W4232269573 @default.
• W3130207430 cites W4249564735 @default.
• W3130207430 doi "https://doi.org/10.1016/j.jep.2021.113940" @default.
• W3130207430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33631275" @default.
• W3130207430 hasPublicationYear "2021" @default.
• W3130207430 type Work @default.
• W3130207430 sameAs 3130207430 @default.
• W3130207430 citedByCount "17" @default.
• W3130207430 countsByYear W31302074302021 @default.
• W3130207430 countsByYear W31302074302022 @default.
• W3130207430 countsByYear W31302074302023 @default.
• W3130207430 crossrefType "journal-article" @default.
• W3130207430 hasAuthorship W3130207430A5003897678 @default.
• W3130207430 hasAuthorship W3130207430A5015390779 @default.
• W3130207430 hasAuthorship W3130207430A5028289172 @default.
• W3130207430 hasAuthorship W3130207430A5041011625 @default.
• W3130207430 hasAuthorship W3130207430A5062745812 @default.
• W3130207430 hasAuthorship W3130207430A5065210033 @default.
• W3130207430 hasAuthorship W3130207430A5073540033 @default.
• W3130207430 hasAuthorship W3130207430A5079123217 @default.
• W3130207430 hasAuthorship W3130207430A5080061299 @default.
• W3130207430 hasConcept C116073593 @default.
• W3130207430 hasConcept C160492267 @default.
• W3130207430 hasConcept C185592680 @default.
• W3130207430 hasConcept C202751555 @default.
• W3130207430 hasConcept C2776473397 @default.
• W3130207430 hasConcept C2781380062 @default.
• W3130207430 hasConcept C55493867 @default.
• W3130207430 hasConcept C556039675 @default.
• W3130207430 hasConcept C71924100 @default.

• next