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• W3130208969 abstract "Introduction In Japan, universal screening for group B streptococcal (GBS) colonization in pregnant women and intrapartum antibiotic prophylaxis (IAP) are recommended to prevent neonatal GBS infection. However, the dynamics of GBS colonization in Japanese mother/neonate pairs have not been adequately studied. Methods A prospective cohort study was conducted from July 2018 to March 2019. Rectovaginal samples were collected from pregnant women (33–37 gestation weeks) once. In neonates, nasopharyngeal and rectal samples were collected at three time points: after birth, 1 week after birth, and 1 month after birth. All samples were analyzed for GBS using real-time PCR testing and culture methods. Capsular typing was performed for all GBS isolates and GBS-positive samples using real-time PCR testing. Results The overall maternal and neonatal GBS-positivity rates were 22.7% (57/251) and 8.8% (22/251), respectively. IAP for GBS-positive mothers (96.5%) was highly administered. Eleven (19.3%) neonates born to GBS-positive mothers were GBS-positive, which was significantly higher than the 11 (5.7%) neonates born to GBS-negative mothers. The rate of GBS-positivity in neonates increased with an increased number of GBS colonies in mothers. More neonates were GBS-positive 1 month after birth than 1 week after birth, and there was a higher rate of GBS-positive rectal swabs than nasopharyngeal swabs. Capsular types of GBS that were isolated from each mother and neonate pair were the same, namely, Ib, III, V, and VI. Conclusions These findings indicate that the efficacy of IAP in preventing GBS transmission to neonates might be limited to within a few weeks after birth." @default.
• W3130208969 created "2021-03-01" @default.
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• W3130208969 date "2021-07-01" @default.
• W3130208969 modified "2023-09-26" @default.
• W3130208969 title "Relationship between intrapartum antibiotic prophylaxis and group B streptococcal colonization dynamics in Japanese mother–neonate pairs" @default.
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• W3130208969 doi "https://doi.org/10.1016/j.jiac.2021.02.006" @default.
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