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- W3130229624 abstract "Activation of T lymphocytes is an essential step in the adaptive immune response, and involves the binding of specialized receptors on the lymphocyte membrane to antigen on the surface of antigen presenting cells (APC). This binding leads to changes in cell morphology and assembly of receptors and signaling proteins into microclusters, which are essential for immune cell activation. Signaling downstream of receptor activation leads to self-organization of the actomyosin and microtubule cytoskeletons into spatiotemporal patterns of signaling proteins, cytoskeletal structures and molecular motors at the lymphocyte-APC interface, also called the immune synapse. We show the existence of an intricate feedback network between receptor signaling, actin polymerization and actomyosin contractility that underlies these patterns. We further demonstrate that microtubule dynamics modulate actin flows, myosin contractility and force generation through Rho-GTPase signaling. In turn, actomyosin dynamics influence microtubule growth and filament shapes indicating a complex interplay between these two cytoskeletal systems during T cell activation. Finally, we discuss how actin and microtubule dynamics enable these cells to sense physical cues such as substrate stiffness and topography." @default.
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- W3130229624 date "2021-02-01" @default.
- W3130229624 modified "2023-09-25" @default.
- W3130229624 title "Cytoskeletal Dynamics and Mechanosensing in Immune Cells" @default.
- W3130229624 doi "https://doi.org/10.1016/j.bpj.2020.11.904" @default.
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