FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130249568> ?p ?o ?g. }

• W3130249568 abstract "Astrocytes are the most abundant cell type within the central nervous system (CNS) with various functions. Furthermore, astrocytes show a regional and developmental heterogeneity traceable with specific markers. In this study, the influence of the low-density lipoprotein receptor-related protein 1 (LRP1) on astrocytic maturation within the hippocampus was analyzed during development. Previous studies mostly focused on the involvement of LRP1 in the neuronal compartment, where the deletion caused hyperactivity and motor dysfunctions in knockout animals. However, the influence of LRP1 on glia cells is less intensively investigated. Therefore, we used a newly generated mouse model, where LRP1 is specifically deleted from GLAST-positive astrocytes co-localized with the expression of the reporter tdTomato to visualize recombination and knockout events in vivo . The influence of LRP1 on the maturation of hippocampal astrocytes was assessed with immunohistochemical stainings against stage-specific markers as well as on mRNA level with RT-PCR analysis. The examination revealed that the knockout induction caused a significantly decreased number of mature astrocytes at an early developmental timepoint compared to control animals. Additionally, the delayed maturation of astrocytes also caused a reduced activity of neurons within the hippocampus. As previous studies showed that the glial specification and maturation of astrocytes is dependent on the signaling cascades Ras/Raf/MEK/Erk and PI3K/Akt, the phosphorylation of the signaling molecules Erk1/2 and Akt was analyzed. The hippocampal tissue of LRP1-deficient animals at P21 showed a significantly decreased amount of activated Erk in comparison to control tissue leading to the conclusion that the activation of this signaling cascade is dependent on LRP1 in astrocytes, which in turn is necessary for proper maturation of astrocytes. Our results showed that the deletion of LRP1 at an early developmental timepoint caused a delayed maturation of astrocytes in the hippocampus based on an altered activation of the Ras/Raf/MEK/Erk signaling pathway. However, with ongoing development these effects were compensated and the number of mature astrocytes was comparable as well as the activity of neurons. Therefore, LRP1 acts as an early regulator of the differentiation and maturation of astrocytes within the hippocampus." @default.
• W3130249568 created "2021-03-01" @default.
• W3130249568 creator A5026189128 @default.
• W3130249568 creator A5045625818 @default.
• W3130249568 creator A5046104281 @default.
• W3130249568 creator A5071825664 @default.
• W3130249568 creator A5074956035 @default.
• W3130249568 date "2021-02-18" @default.
• W3130249568 modified "2023-10-17" @default.
• W3130249568 title "Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) as a Novel Regulator of Early Astroglial Differentiation" @default.
• W3130249568 cites W1543151032 @default.
• W3130249568 cites W1551858048 @default.
• W3130249568 cites W1551925364 @default.
• W3130249568 cites W1585007382 @default.
• W3130249568 cites W1603509064 @default.
• W3130249568 cites W1968639426 @default.
• W3130249568 cites W1972325849 @default.
• W3130249568 cites W1974824219 @default.
• W3130249568 cites W1976325242 @default.
• W3130249568 cites W1976824219 @default.
• W3130249568 cites W1983376590 @default.
• W3130249568 cites W2006729877 @default.
• W3130249568 cites W2014696861 @default.
• W3130249568 cites W2022831509 @default.
• W3130249568 cites W2023144530 @default.
• W3130249568 cites W2044730840 @default.
• W3130249568 cites W2045436839 @default.
• W3130249568 cites W2047958956 @default.
• W3130249568 cites W2049105739 @default.
• W3130249568 cites W2052730691 @default.
• W3130249568 cites W2054226892 @default.
• W3130249568 cites W2058806480 @default.
• W3130249568 cites W2060319077 @default.
• W3130249568 cites W2064836594 @default.
• W3130249568 cites W2065802840 @default.
• W3130249568 cites W2066113694 @default.
• W3130249568 cites W2070081929 @default.
• W3130249568 cites W2072082423 @default.
• W3130249568 cites W2072589738 @default.
• W3130249568 cites W2074661552 @default.
• W3130249568 cites W2077664347 @default.
• W3130249568 cites W2079241115 @default.
• W3130249568 cites W2083712812 @default.
• W3130249568 cites W2094247513 @default.
• W3130249568 cites W2100007797 @default.
• W3130249568 cites W2100486119 @default.
• W3130249568 cites W2113546972 @default.
• W3130249568 cites W2115920804 @default.
• W3130249568 cites W2116010085 @default.
• W3130249568 cites W2121860798 @default.
• W3130249568 cites W2140624006 @default.
• W3130249568 cites W2147372806 @default.
• W3130249568 cites W2147869206 @default.
• W3130249568 cites W2151010413 @default.
• W3130249568 cites W2152904049 @default.
• W3130249568 cites W2156295356 @default.
• W3130249568 cites W2167111298 @default.
• W3130249568 cites W2170044387 @default.
• W3130249568 cites W2172266256 @default.
• W3130249568 cites W2255800692 @default.
• W3130249568 cites W2340761255 @default.
• W3130249568 cites W2412711573 @default.
• W3130249568 cites W2490845856 @default.
• W3130249568 cites W2552741630 @default.
• W3130249568 cites W2593036876 @default.
• W3130249568 cites W2605039207 @default.
• W3130249568 cites W2752591735 @default.
• W3130249568 cites W2781911216 @default.
• W3130249568 cites W2797019545 @default.
• W3130249568 cites W2901720512 @default.
• W3130249568 cites W2924411868 @default.
• W3130249568 cites W2971321301 @default.
• W3130249568 cites W2991294277 @default.
• W3130249568 cites W3037032943 @default.
• W3130249568 cites W3119291887 @default.
• W3130249568 cites W4251348452 @default.
• W3130249568 cites W4292820908 @default.
• W3130249568 doi "https://doi.org/10.3389/fncel.2021.642521" @default.
• W3130249568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7930235" @default.
• W3130249568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33679332" @default.
• W3130249568 hasPublicationYear "2021" @default.
• W3130249568 type Work @default.
• W3130249568 sameAs 3130249568 @default.
• W3130249568 citedByCount "7" @default.
• W3130249568 countsByYear W31302495682021 @default.
• W3130249568 countsByYear W31302495682022 @default.
• W3130249568 countsByYear W31302495682023 @default.
• W3130249568 crossrefType "journal-article" @default.
• W3130249568 hasAuthorship W3130249568A5026189128 @default.
• W3130249568 hasAuthorship W3130249568A5045625818 @default.
• W3130249568 hasAuthorship W3130249568A5046104281 @default.
• W3130249568 hasAuthorship W3130249568A5071825664 @default.
• W3130249568 hasAuthorship W3130249568A5074956035 @default.
• W3130249568 hasBestOaLocation W31302495681 @default.
• W3130249568 hasConcept C11960822 @default.
• W3130249568 hasConcept C134018914 @default.
• W3130249568 hasConcept C139647698 @default.
• W3130249568 hasConcept C148762608 @default.
• W3130249568 hasConcept C169760540 @default.
• W3130249568 hasConcept C170493617 @default.

• next