Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130300758> ?p ?o ?g. }
- W3130300758 endingPage "1372" @default.
- W3130300758 startingPage "1363" @default.
- W3130300758 abstract "Two series of quinoxaline–chalcone conjugates have been prepared by aldolic condensation and aromatic nucleophilic substitution reaction, and their anticancer activity against three cancer cell lines including benign prostatic hyperplasia epithelial cell (BPH-1), neuron-like rat pheochromocytoma cell line (PC12) and human breast cancer cell line (MCF-7) were evaluated in vitro. All of the synthesized compounds exhibited moderate to good activity against the cancer cell lines selected. Particularly, Compound A5 showed the excellent potent activity against BPH-1 and MCF-7 with IC50 values of 10.4 and 9.1 μM, respectively, which is similar to doxorubicin (14.1 and 9.2 μM, respectively). As well as compound B6 exhibited most excellent activity toward PC12 with IC50 values of 16.4 μM. Compound A10 exhibited 55.4, 36.8 and 54.5 folds higher selectivity for BPH-1, PC12 and MCF-7 cells than for HEK-293 cell, respectively. In addition, theoretical biological activities of compounds A5 and A10 were evaluated by SwissADME." @default.
- W3130300758 created "2021-03-01" @default.
- W3130300758 creator A5000466173 @default.
- W3130300758 creator A5026817382 @default.
- W3130300758 creator A5047164982 @default.
- W3130300758 creator A5055113251 @default.
- W3130300758 creator A5090773574 @default.
- W3130300758 date "2021-02-12" @default.
- W3130300758 modified "2023-10-10" @default.
- W3130300758 title "Synthesis and anticancer activity of chalcone–quinoxalin conjugates" @default.
- W3130300758 cites W1522357457 @default.
- W3130300758 cites W1982839723 @default.
- W3130300758 cites W1996264088 @default.
- W3130300758 cites W2028270779 @default.
- W3130300758 cites W2033982758 @default.
- W3130300758 cites W2047903898 @default.
- W3130300758 cites W2052506144 @default.
- W3130300758 cites W2054231371 @default.
- W3130300758 cites W2058135376 @default.
- W3130300758 cites W2059943906 @default.
- W3130300758 cites W2135732933 @default.
- W3130300758 cites W2315218945 @default.
- W3130300758 cites W2570271218 @default.
- W3130300758 cites W2605194124 @default.
- W3130300758 cites W2613820968 @default.
- W3130300758 cites W2761849826 @default.
- W3130300758 cites W2770776957 @default.
- W3130300758 cites W2771006473 @default.
- W3130300758 cites W2776146663 @default.
- W3130300758 cites W2782082879 @default.
- W3130300758 cites W2789374950 @default.
- W3130300758 cites W2809040279 @default.
- W3130300758 cites W2884672240 @default.
- W3130300758 cites W2900599172 @default.
- W3130300758 cites W2900898785 @default.
- W3130300758 cites W2901808402 @default.
- W3130300758 cites W2908870416 @default.
- W3130300758 cites W2915165404 @default.
- W3130300758 cites W2946780854 @default.
- W3130300758 cites W2949334322 @default.
- W3130300758 cites W2949760404 @default.
- W3130300758 cites W2974793213 @default.
- W3130300758 cites W2985471550 @default.
- W3130300758 cites W2990489433 @default.
- W3130300758 cites W3003630409 @default.
- W3130300758 cites W3011543462 @default.
- W3130300758 cites W3012480985 @default.
- W3130300758 cites W3016704946 @default.
- W3130300758 doi "https://doi.org/10.1080/00397911.2021.1881124" @default.
- W3130300758 hasPublicationYear "2021" @default.
- W3130300758 type Work @default.
- W3130300758 sameAs 3130300758 @default.
- W3130300758 citedByCount "5" @default.
- W3130300758 countsByYear W31303007582021 @default.
- W3130300758 countsByYear W31303007582022 @default.
- W3130300758 countsByYear W31303007582023 @default.
- W3130300758 crossrefType "journal-article" @default.
- W3130300758 hasAuthorship W3130300758A5000466173 @default.
- W3130300758 hasAuthorship W3130300758A5026817382 @default.
- W3130300758 hasAuthorship W3130300758A5047164982 @default.
- W3130300758 hasAuthorship W3130300758A5055113251 @default.
- W3130300758 hasAuthorship W3130300758A5090773574 @default.
- W3130300758 hasConcept C126322002 @default.
- W3130300758 hasConcept C134306372 @default.
- W3130300758 hasConcept C178790620 @default.
- W3130300758 hasConcept C185592680 @default.
- W3130300758 hasConcept C190283241 @default.
- W3130300758 hasConcept C197336794 @default.
- W3130300758 hasConcept C202751555 @default.
- W3130300758 hasConcept C21951064 @default.
- W3130300758 hasConcept C2776694085 @default.
- W3130300758 hasConcept C2777752497 @default.
- W3130300758 hasConcept C2780362310 @default.
- W3130300758 hasConcept C2780764945 @default.
- W3130300758 hasConcept C2781303535 @default.
- W3130300758 hasConcept C33923547 @default.
- W3130300758 hasConcept C54355233 @default.
- W3130300758 hasConcept C55493867 @default.
- W3130300758 hasConcept C71240020 @default.
- W3130300758 hasConcept C71924100 @default.
- W3130300758 hasConcept C81885089 @default.
- W3130300758 hasConcept C86803240 @default.
- W3130300758 hasConcept C98274493 @default.
- W3130300758 hasConceptScore W3130300758C126322002 @default.
- W3130300758 hasConceptScore W3130300758C134306372 @default.
- W3130300758 hasConceptScore W3130300758C178790620 @default.
- W3130300758 hasConceptScore W3130300758C185592680 @default.
- W3130300758 hasConceptScore W3130300758C190283241 @default.
- W3130300758 hasConceptScore W3130300758C197336794 @default.
- W3130300758 hasConceptScore W3130300758C202751555 @default.
- W3130300758 hasConceptScore W3130300758C21951064 @default.
- W3130300758 hasConceptScore W3130300758C2776694085 @default.
- W3130300758 hasConceptScore W3130300758C2777752497 @default.
- W3130300758 hasConceptScore W3130300758C2780362310 @default.
- W3130300758 hasConceptScore W3130300758C2780764945 @default.
- W3130300758 hasConceptScore W3130300758C2781303535 @default.
- W3130300758 hasConceptScore W3130300758C33923547 @default.
- W3130300758 hasConceptScore W3130300758C54355233 @default.