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- W3130333491 abstract "Introduction: Epithelial Ovarian Carcinoma (EOC) comprises the vastmajority (almost 90%) of ovarian carcinomas. Chemotherapy is the main treatmentin ovarian cancers. The standard of care in the chemotherapeutic is the combinationof a platinum (carboplatin or cisplatin) and a taxane (paclitaxel or docetaxel).Studies were done to determine whether this combination to be given weekly or every3 weeks. Patient and Method: Inclusion criteria: 1) Female patients betweenthe ages of 17 - 78 years. 2) Baseline hematological, renal and liver laboratoryprofiles were within accepted ranges. 3) Performance status of the patients was0-II. 4) Patients were pathologically proven ovarian cancer. 5) A follow-up periodfor at least 6 months was required. Exclusion criteria: 1) Patients who had doublemalignancy were excluded. 2) Performance status more than II. 3) Other comorbidity. Results: We reviewed 69 female patients with EOC, with 60% received everythree weeks regimen. Mean age was 53.22 years. At a median follow up of 45.9 months,there was no significant different between the two protocols in terms of mean PFS,62.35 months (95% CI: 50.08 - 74.63 months) for the three-weekly cohort, and 69.25months (95% CI: 55.24 - 83.26 months) for weekly protocol (p = 0.613). The threeweekly regimen patients had a higher incidence of hospital admission (40% vs 18.5%for the weekly protocol patients), but it didn’t reach a statistical significance(p = 0.063). The three weekly protocol had a significantly higher incidence of causinga neutropenic fever (p = 0.003). Conclusion: In our cohort of Egyptian womenwith EOC, no significant difference in PFS was found when compared the weekly Carboplatin/paclitaxelwhen compared to the classic three weeks, although the weekly protocol may be causingless febrile neutropenia and fewer hospital admissions." @default.
- W3130333491 created "2021-03-01" @default.
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- W3130333491 date "2021-01-01" @default.
- W3130333491 modified "2023-10-18" @default.
- W3130333491 title "Three Weeks Carboplatin/Paclitaxel versus Weekly Regimen in Egyptian Women Cohort Treated for Ovarian Carcinoma" @default.
- W3130333491 cites W2130806638 @default.
- W3130333491 doi "https://doi.org/10.4236/jct.2021.122009" @default.
- W3130333491 hasPublicationYear "2021" @default.
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