Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130354375> ?p ?o ?g. }
- W3130354375 endingPage "113290" @default.
- W3130354375 startingPage "113290" @default.
- W3130354375 abstract "Kinetoplastid parasites are the causative agents of neglected tropical diseases with an unmet medical need. These parasites are unable to synthesize the purine ring de novo, and therefore rely on purine salvage to meet their purine demand. Evaluating purine nucleoside analogs is therefore an attractive strategy to identify antikinetoplastid agents. Several anti-Trypanosoma cruzi and anti-Trypanosoma brucei 7-deazapurine nucleosides were previously discovered, with the removal of the 3′-hydroxyl group resulting in a significant boost in activity. In this work we therefore decided to assess the effect of the introduction of a 3′-fluoro substituent in 7-deazapurine nucleosides on the anti-kinetoplastid activities. Hence, we synthesized two series of 3′-deoxy-3′-fluororibofuranosyl and 3′-deoxy-3′-fluoroxylofuranosyl nucleosides comprising 7-deazaadenine and -hypoxanthine bases and assayed these for antiparasitic activity. Several analogs with potent activity against T. cruzi and T. brucei were discovered, indicating that a fluorine atom in the 3′-position is a promising modification for the discovery of antiparasitic nucleosides." @default.
- W3130354375 created "2021-03-01" @default.
- W3130354375 creator A5000641826 @default.
- W3130354375 creator A5013501595 @default.
- W3130354375 creator A5029887044 @default.
- W3130354375 creator A5055857585 @default.
- W3130354375 creator A5064326940 @default.
- W3130354375 creator A5064901452 @default.
- W3130354375 date "2021-04-01" @default.
- W3130354375 modified "2023-10-17" @default.
- W3130354375 title "Synthesis and evaluation of 3′-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents" @default.
- W3130354375 cites W119860570 @default.
- W3130354375 cites W1727546762 @default.
- W3130354375 cites W1968652333 @default.
- W3130354375 cites W1972841836 @default.
- W3130354375 cites W1977651038 @default.
- W3130354375 cites W1978063347 @default.
- W3130354375 cites W1978423896 @default.
- W3130354375 cites W1996032373 @default.
- W3130354375 cites W2005775505 @default.
- W3130354375 cites W2005829971 @default.
- W3130354375 cites W2007905920 @default.
- W3130354375 cites W2026881670 @default.
- W3130354375 cites W2030983579 @default.
- W3130354375 cites W2035491456 @default.
- W3130354375 cites W2036330755 @default.
- W3130354375 cites W2046952085 @default.
- W3130354375 cites W2061023393 @default.
- W3130354375 cites W2083470546 @default.
- W3130354375 cites W2124017549 @default.
- W3130354375 cites W2125029088 @default.
- W3130354375 cites W2146469849 @default.
- W3130354375 cites W2146992057 @default.
- W3130354375 cites W2175063038 @default.
- W3130354375 cites W2198907191 @default.
- W3130354375 cites W2202846426 @default.
- W3130354375 cites W2264719596 @default.
- W3130354375 cites W2308248585 @default.
- W3130354375 cites W2312672944 @default.
- W3130354375 cites W2312814254 @default.
- W3130354375 cites W2316482543 @default.
- W3130354375 cites W2325699656 @default.
- W3130354375 cites W2520184038 @default.
- W3130354375 cites W2529182798 @default.
- W3130354375 cites W2565733028 @default.
- W3130354375 cites W2589958932 @default.
- W3130354375 cites W2745573854 @default.
- W3130354375 cites W2884746110 @default.
- W3130354375 cites W2889641285 @default.
- W3130354375 cites W2903201327 @default.
- W3130354375 cites W2904565628 @default.
- W3130354375 cites W2905745968 @default.
- W3130354375 cites W2908991243 @default.
- W3130354375 cites W2910077302 @default.
- W3130354375 cites W2922228539 @default.
- W3130354375 cites W2951869190 @default.
- W3130354375 cites W2952340836 @default.
- W3130354375 cites W2953246017 @default.
- W3130354375 cites W2973219135 @default.
- W3130354375 cites W2994511534 @default.
- W3130354375 cites W3001506397 @default.
- W3130354375 cites W3008871853 @default.
- W3130354375 cites W3036033111 @default.
- W3130354375 cites W4210387299 @default.
- W3130354375 cites W4210992500 @default.
- W3130354375 cites W4211073781 @default.
- W3130354375 cites W4235209138 @default.
- W3130354375 cites W4238917801 @default.
- W3130354375 cites W1492065997 @default.
- W3130354375 doi "https://doi.org/10.1016/j.ejmech.2021.113290" @default.
- W3130354375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33667845" @default.
- W3130354375 hasPublicationYear "2021" @default.
- W3130354375 type Work @default.
- W3130354375 sameAs 3130354375 @default.
- W3130354375 citedByCount "12" @default.
- W3130354375 countsByYear W31303543752021 @default.
- W3130354375 countsByYear W31303543752022 @default.
- W3130354375 countsByYear W31303543752023 @default.
- W3130354375 crossrefType "journal-article" @default.
- W3130354375 hasAuthorship W3130354375A5000641826 @default.
- W3130354375 hasAuthorship W3130354375A5013501595 @default.
- W3130354375 hasAuthorship W3130354375A5029887044 @default.
- W3130354375 hasAuthorship W3130354375A5055857585 @default.
- W3130354375 hasAuthorship W3130354375A5064326940 @default.
- W3130354375 hasAuthorship W3130354375A5064901452 @default.
- W3130354375 hasBestOaLocation W31303543752 @default.
- W3130354375 hasConcept C104317684 @default.
- W3130354375 hasConcept C136764020 @default.
- W3130354375 hasConcept C142724271 @default.
- W3130354375 hasConcept C169586020 @default.
- W3130354375 hasConcept C181199279 @default.
- W3130354375 hasConcept C185592680 @default.
- W3130354375 hasConcept C21951064 @default.
- W3130354375 hasConcept C2776476023 @default.
- W3130354375 hasConcept C2776543447 @default.
- W3130354375 hasConcept C2776684476 @default.
- W3130354375 hasConcept C2777625466 @default.
- W3130354375 hasConcept C2779502636 @default.