Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130362014> ?p ?o ?g. }
- W3130362014 endingPage "453" @default.
- W3130362014 startingPage "440" @default.
- W3130362014 abstract "The purpose of this study was to develop novel carbopol-based miltefosine-loaded transfersomal gel (HePCTG) for the treatment of cutaneous leishmaniasis (CL) via efficient targeting of leishmania infected macrophages.Miltefosine-loaded transfersomes (HePCT) were prepared by ethanol injection method followed by their incorporation into carbopol gel to form HePCTG. The prepared HePCT were assessed for physicochemical properties including mean particle size, polydispersity index, zeta potential, entrapment efficiency, morphology, and deformability. Similarly, HePCTG was evaluated for physiochemical and rheological attributes. The in vitro release, skin permeation, skin irritation, anti-leishmanial activity, and in vivo efficacy in BALB/c mice against infected macrophages were also performed for HePCT.The optimized HePCT displayed a particle size of 168 nm with entrapment efficiency of 92%. HePCTG showed suitable viscosity, pH, and sustained release of the incorporated drug. Furthermore, HePCT and HePCTG demonstrated higher skin permeation than drug solution. The results of macrophage uptake study indicated improved drug intake by passive diffusion. The lower half maximal inhibitory concentration value, selectivity index and higher 50% cytotoxic concentration value of HePCT compared to that of HePC solution demonstrated the improved anti-leishmanial efficacy and non-toxicity of the formulation. This was further confirmed by the notable reduction in parasite load and lesion size observed in in vivo anti-leishmanial study.It can be stated that the formulated HePCTG can effectively be used for the treatment of CL." @default.
- W3130362014 created "2021-03-01" @default.
- W3130362014 creator A5009572327 @default.
- W3130362014 creator A5011430977 @default.
- W3130362014 creator A5023049457 @default.
- W3130362014 creator A5048315421 @default.
- W3130362014 creator A5051659421 @default.
- W3130362014 creator A5079229090 @default.
- W3130362014 creator A5082187713 @default.
- W3130362014 creator A5082933658 @default.
- W3130362014 date "2021-03-01" @default.
- W3130362014 modified "2023-10-16" @default.
- W3130362014 title "Macrophage targeting with the novel carbopol-based miltefosine-loaded transfersomal gel for the treatment of cutaneous leishmaniasis: <i>in vitro</i> and <i>in vivo</i> analyses" @default.
- W3130362014 cites W1500036797 @default.
- W3130362014 cites W1752411429 @default.
- W3130362014 cites W1931062709 @default.
- W3130362014 cites W1963804264 @default.
- W3130362014 cites W1963868129 @default.
- W3130362014 cites W1976174823 @default.
- W3130362014 cites W1990107938 @default.
- W3130362014 cites W1992198240 @default.
- W3130362014 cites W1992862573 @default.
- W3130362014 cites W1994988652 @default.
- W3130362014 cites W2002259662 @default.
- W3130362014 cites W2014093866 @default.
- W3130362014 cites W2015705442 @default.
- W3130362014 cites W2018761941 @default.
- W3130362014 cites W2024183797 @default.
- W3130362014 cites W2029383767 @default.
- W3130362014 cites W2032557013 @default.
- W3130362014 cites W2033198837 @default.
- W3130362014 cites W2038206223 @default.
- W3130362014 cites W2040329251 @default.
- W3130362014 cites W2040960783 @default.
- W3130362014 cites W2041912496 @default.
- W3130362014 cites W2042056598 @default.
- W3130362014 cites W2044569715 @default.
- W3130362014 cites W2050319494 @default.
- W3130362014 cites W2068517215 @default.
- W3130362014 cites W2069516100 @default.
- W3130362014 cites W2069913623 @default.
- W3130362014 cites W2070854001 @default.
- W3130362014 cites W2072810264 @default.
- W3130362014 cites W2077115584 @default.
- W3130362014 cites W2085496520 @default.
- W3130362014 cites W2086889742 @default.
- W3130362014 cites W2088146841 @default.
- W3130362014 cites W2090026085 @default.
- W3130362014 cites W2091254406 @default.
- W3130362014 cites W2102432127 @default.
- W3130362014 cites W2126420606 @default.
- W3130362014 cites W2131226058 @default.
- W3130362014 cites W2138731219 @default.
- W3130362014 cites W2140194898 @default.
- W3130362014 cites W2148253800 @default.
- W3130362014 cites W2157575107 @default.
- W3130362014 cites W2160700506 @default.
- W3130362014 cites W2161034880 @default.
- W3130362014 cites W2165720802 @default.
- W3130362014 cites W2174575899 @default.
- W3130362014 cites W2317256715 @default.
- W3130362014 cites W2332381288 @default.
- W3130362014 cites W2403390081 @default.
- W3130362014 cites W2508207342 @default.
- W3130362014 cites W2559613082 @default.
- W3130362014 cites W2563286746 @default.
- W3130362014 cites W2585870619 @default.
- W3130362014 cites W258735800 @default.
- W3130362014 cites W2587424776 @default.
- W3130362014 cites W2590522249 @default.
- W3130362014 cites W2593975115 @default.
- W3130362014 cites W2606767558 @default.
- W3130362014 cites W2609425092 @default.
- W3130362014 cites W2734502973 @default.
- W3130362014 cites W2736859840 @default.
- W3130362014 cites W2741336675 @default.
- W3130362014 cites W2768292016 @default.
- W3130362014 cites W2790036073 @default.
- W3130362014 cites W2802518241 @default.
- W3130362014 cites W2885791666 @default.
- W3130362014 cites W2902373780 @default.
- W3130362014 cites W2903490844 @default.
- W3130362014 cites W2922428194 @default.
- W3130362014 cites W2944225234 @default.
- W3130362014 cites W2990549636 @default.
- W3130362014 cites W2998812277 @default.
- W3130362014 cites W2999994762 @default.
- W3130362014 cites W3062649171 @default.
- W3130362014 cites W3080894464 @default.
- W3130362014 cites W3109450700 @default.
- W3130362014 cites W3111022699 @default.
- W3130362014 doi "https://doi.org/10.1080/03639045.2021.1890768" @default.
- W3130362014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33615936" @default.
- W3130362014 hasPublicationYear "2021" @default.
- W3130362014 type Work @default.
- W3130362014 sameAs 3130362014 @default.
- W3130362014 citedByCount "35" @default.
- W3130362014 countsByYear W31303620142021 @default.