Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130394213> ?p ?o ?g. }
- W3130394213 endingPage "115467" @default.
- W3130394213 startingPage "115467" @default.
- W3130394213 abstract "Owing to the technological advancements, including next generation sequencing, the significance of deregulated epigenetic mechanisms in cancer initiation, progression and treatment has become evident. The accumulating knowledge relating to the epigenetic markers viz. DNA methylation, Histone modifications and non-coding RNAs make them one of the most interesting candidates for developing anti-cancer therapies. The reversibility of deregulated epigenetic mechanisms through environmental and dietary factors opens numerous avenues in the field of chemoprevention and drug development. Recent studies have proven that plant-derived natural products encompass a great potential in targeting epigenetic signatures in cancer and numerous natural products are being explored for their possibility to be considered as “epi-drug”. This review intends to highlight the major aberrant epigenetic mechanisms and summarizes the essential functions of natural products like Resveratrol, Quercetin, Genistein, EGCG, Curcumin, Sulforaphane, Apigenin, Parthenolide and Berberine in modulating these aberrations. This knowledge along with the challenges and limitations in this field has potential and wider implications in developing novel and successful therapeutic strategies. The increased focus in the area will possibly provide a better understanding for the development of dietary supplements and/or drugs either alone or in combination. The interaction of epigenetics with different hallmarks of cancer and how natural products can be utilized to target them will also be interesting in the future therapeutic approaches." @default.
- W3130394213 created "2021-03-01" @default.
- W3130394213 creator A5013391906 @default.
- W3130394213 creator A5039867335 @default.
- W3130394213 date "2021-04-01" @default.
- W3130394213 modified "2023-09-25" @default.
- W3130394213 title "Natural products in the reprogramming of cancer epigenetics" @default.
- W3130394213 cites W1485777439 @default.
- W3130394213 cites W1503744211 @default.
- W3130394213 cites W1568374929 @default.
- W3130394213 cites W1598891758 @default.
- W3130394213 cites W1644599364 @default.
- W3130394213 cites W1862685904 @default.
- W3130394213 cites W1913764854 @default.
- W3130394213 cites W1967547933 @default.
- W3130394213 cites W1967692894 @default.
- W3130394213 cites W1971687421 @default.
- W3130394213 cites W1972149587 @default.
- W3130394213 cites W1972339856 @default.
- W3130394213 cites W1977882528 @default.
- W3130394213 cites W1978419388 @default.
- W3130394213 cites W1980854517 @default.
- W3130394213 cites W1981259130 @default.
- W3130394213 cites W1993316747 @default.
- W3130394213 cites W1994089958 @default.
- W3130394213 cites W2002689861 @default.
- W3130394213 cites W2006535320 @default.
- W3130394213 cites W2007228943 @default.
- W3130394213 cites W2009604514 @default.
- W3130394213 cites W2010484468 @default.
- W3130394213 cites W2019871537 @default.
- W3130394213 cites W2022777430 @default.
- W3130394213 cites W2023283464 @default.
- W3130394213 cites W2025998934 @default.
- W3130394213 cites W2034591470 @default.
- W3130394213 cites W2041361896 @default.
- W3130394213 cites W2042889901 @default.
- W3130394213 cites W2043206390 @default.
- W3130394213 cites W2051614253 @default.
- W3130394213 cites W2053526397 @default.
- W3130394213 cites W2054020882 @default.
- W3130394213 cites W2055021348 @default.
- W3130394213 cites W2061152470 @default.
- W3130394213 cites W2061801920 @default.
- W3130394213 cites W2062838782 @default.
- W3130394213 cites W2063460304 @default.
- W3130394213 cites W2068719521 @default.
- W3130394213 cites W2069901047 @default.
- W3130394213 cites W2073552107 @default.
- W3130394213 cites W2075938797 @default.
- W3130394213 cites W2087966689 @default.
- W3130394213 cites W2091741011 @default.
- W3130394213 cites W2092003419 @default.
- W3130394213 cites W2093500779 @default.
- W3130394213 cites W2094998522 @default.
- W3130394213 cites W2096083625 @default.
- W3130394213 cites W2096550742 @default.
- W3130394213 cites W2097086855 @default.
- W3130394213 cites W2099474252 @default.
- W3130394213 cites W2100680346 @default.
- W3130394213 cites W2101176115 @default.
- W3130394213 cites W2101546285 @default.
- W3130394213 cites W2101875154 @default.
- W3130394213 cites W2102242260 @default.
- W3130394213 cites W2102516914 @default.
- W3130394213 cites W2103177465 @default.
- W3130394213 cites W2109223814 @default.
- W3130394213 cites W2111546204 @default.
- W3130394213 cites W2113950481 @default.
- W3130394213 cites W2116068882 @default.
- W3130394213 cites W2118659571 @default.
- W3130394213 cites W2127905879 @default.
- W3130394213 cites W2128428442 @default.
- W3130394213 cites W2128986224 @default.
- W3130394213 cites W2129262211 @default.
- W3130394213 cites W2129522972 @default.
- W3130394213 cites W2131869035 @default.
- W3130394213 cites W2133719858 @default.
- W3130394213 cites W2133816851 @default.
- W3130394213 cites W2138018577 @default.
- W3130394213 cites W2138888816 @default.
- W3130394213 cites W2139797259 @default.
- W3130394213 cites W2141410747 @default.
- W3130394213 cites W2141992776 @default.
- W3130394213 cites W2147524392 @default.
- W3130394213 cites W2151154588 @default.
- W3130394213 cites W2152656267 @default.
- W3130394213 cites W2155977101 @default.
- W3130394213 cites W2158796211 @default.
- W3130394213 cites W2161784983 @default.
- W3130394213 cites W2161993805 @default.
- W3130394213 cites W2162798884 @default.
- W3130394213 cites W2170106121 @default.
- W3130394213 cites W2170862030 @default.
- W3130394213 cites W2195584918 @default.
- W3130394213 cites W2207293453 @default.
- W3130394213 cites W2217934185 @default.
- W3130394213 cites W2256742438 @default.