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• W3130410462 endingPage "153527" @default.
• W3130410462 startingPage "153527" @default.
• W3130410462 abstract "SiNiSan (SNS) is an ancient Chinese herbal prescription, and the current clinical treatment of irritable bowel syndrome (IBS) is effective. In the previous study of the research team, the multi-functional co-synergism of SNS against IBS was presented. Some potential drug targets and candidate ligands were predicted. This study attempts to explore the crucial ingredient combinations from SNS formula and reveal their synergistic mechanism for IBS therapy. In present study, a comprehensive strategy was performed to reveal IBS related pathways and biological modules, and explore synergistic effects of the ingredients, including ADME (absorption, distribution, metabolism, excretion) screening, Text mining, Venn analysis, Gene ontology (GO) analysis, Pathway cluster analysis, Molecular docking, Network construction and Experimental verification in visceral hypersensitivity (VHS) rats. Three compressed IBS signal pathways were derived from ClueGO KEGG analysis of 63 IBS genes, including Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP (transient receptor potential) channels and Serotonergic synapse. A multi-module network, composed of four IBS therapeutic modules (psychological, inflammation, neuroendocrine and cross-talk modules), was revealed by Target-Pathway network. Nine kernel targets were considered closely associated with the IBS pathways, including ADRA2A, HTR2A, F2RL1, F2RL3, TRPV1, PKC, PKA, IL-1Β and NGF. In silico analysis revealed that three crucial ingredients (synephrine, paeoniflorin and naringin) were assumed to coordinate the network of those IBS therapeutic modules by acting on these kernel targets in the important pathways. In vivo experimental results showed that the crucial ingredient combinations synergistically affected the expressions of the kernel biological molecules, and improved the minimum capacity threshold of AWR in VHS rats. The study proposes the important IBS associated pathways and the network regulation mechanisms of the crucial ingredients. It reveals the multi-target synergistic effect of the crucial ingredient combinations for the novel therapy on IBS." @default.
• W3130410462 created "2021-03-01" @default.
• W3130410462 creator A5005684747 @default.
• W3130410462 creator A5020258987 @default.
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• W3130410462 creator A5044936528 @default.
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• W3130410462 creator A5082956691 @default.
• W3130410462 date "2021-06-01" @default.
• W3130410462 modified "2023-10-16" @default.
• W3130410462 title "Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: Combined effects of synephrine, paeoniflorin and naringin" @default.
• W3130410462 cites W1527988408 @default.
• W3130410462 cites W1854632697 @default.
• W3130410462 cites W1964966858 @default.
• W3130410462 cites W1967913887 @default.
• W3130410462 cites W1969874126 @default.
• W3130410462 cites W1970138930 @default.
• W3130410462 cites W1971010175 @default.
• W3130410462 cites W1971578783 @default.
• W3130410462 cites W1972429412 @default.
• W3130410462 cites W1980296966 @default.
• W3130410462 cites W1982624151 @default.
• W3130410462 cites W1983351182 @default.
• W3130410462 cites W1984033377 @default.
• W3130410462 cites W1985981433 @default.
• W3130410462 cites W1988259820 @default.
• W3130410462 cites W1990998281 @default.
• W3130410462 cites W1991774590 @default.
• W3130410462 cites W1993640621 @default.
• W3130410462 cites W1993895508 @default.
• W3130410462 cites W1999069112 @default.
• W3130410462 cites W2008576470 @default.
• W3130410462 cites W2018477911 @default.
• W3130410462 cites W2019433051 @default.
• W3130410462 cites W2034342638 @default.
• W3130410462 cites W2034431735 @default.
• W3130410462 cites W2041016398 @default.
• W3130410462 cites W2047958166 @default.
• W3130410462 cites W2056888789 @default.
• W3130410462 cites W2064201279 @default.
• W3130410462 cites W2064822275 @default.
• W3130410462 cites W2069433956 @default.
• W3130410462 cites W2080307391 @default.
• W3130410462 cites W2084209221 @default.
• W3130410462 cites W2085538087 @default.
• W3130410462 cites W2086996641 @default.
• W3130410462 cites W2088026610 @default.
• W3130410462 cites W2098609823 @default.
• W3130410462 cites W2100382861 @default.
• W3130410462 cites W2103063851 @default.
• W3130410462 cites W2116230226 @default.
• W3130410462 cites W2116317162 @default.
• W3130410462 cites W2123383233 @default.
• W3130410462 cites W2128908882 @default.
• W3130410462 cites W2131368980 @default.
• W3130410462 cites W2133012565 @default.
• W3130410462 cites W2138706910 @default.
• W3130410462 cites W2149216059 @default.
• W3130410462 cites W2150068160 @default.
• W3130410462 cites W2153121902 @default.
• W3130410462 cites W2158380688 @default.
• W3130410462 cites W2159809460 @default.
• W3130410462 cites W2169589032 @default.
• W3130410462 cites W2170825789 @default.
• W3130410462 cites W2272667938 @default.
• W3130410462 cites W2345198528 @default.
• W3130410462 cites W2372756678 @default.
• W3130410462 cites W2439175145 @default.
• W3130410462 cites W2495941601 @default.
• W3130410462 cites W2518978924 @default.
• W3130410462 cites W2526304203 @default.
• W3130410462 cites W2537679995 @default.
• W3130410462 cites W2559034752 @default.
• W3130410462 cites W2582063619 @default.
• W3130410462 cites W2584273077 @default.
• W3130410462 cites W2599204814 @default.
• W3130410462 cites W2760242482 @default.
• W3130410462 cites W2772220218 @default.
• W3130410462 cites W2788650779 @default.
• W3130410462 cites W2793257909 @default.
• W3130410462 cites W2794357741 @default.
• W3130410462 cites W2795382761 @default.
• W3130410462 cites W2810678013 @default.
• W3130410462 cites W2903515937 @default.
• W3130410462 cites W2904545963 @default.
• W3130410462 cites W2948041310 @default.
• W3130410462 cites W2998742313 @default.
• W3130410462 cites W3003169303 @default.
• W3130410462 cites W3005612885 @default.
• W3130410462 cites W3016885747 @default.
• W3130410462 cites W3021540126 @default.
• W3130410462 cites W4229926554 @default.
• W3130410462 cites W4242729757 @default.
• W3130410462 cites W86345978 @default.
• W3130410462 cites W2281470566 @default.
• W3130410462 doi "https://doi.org/10.1016/j.phymed.2021.153527" @default.
• W3130410462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33845366" @default.
• W3130410462 hasPublicationYear "2021" @default.

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