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- W3130488930 endingPage "287" @default.
- W3130488930 startingPage "275" @default.
- W3130488930 abstract "Diabetic retinopathy (DR) is one of the most common forms of microvascular complications of diabetes. Unfortunately, there is no cure for this debilitating ocular complication that holds particular significance due to its detrimental effects on vision, which ultimately leads to vision loss and blindness. Hyperglycemia, the most prominent characteristic of diabetes, plays a major role in initiating the development and progression of DR. One of the histological hallmarks of the pathogenesis of DR is characterized by the thickening of the basement membrane (BM). Abnormalities in the BM ultrastructure affect retinal vascular cell attachment and compromises the inner blood–retinal barrier. While strides are being made to better understand the cellular events regulating retinal capillary BM thickening, including high glucose-induced upregulation of type IV collagen, fibronectin, and laminin genes together with decreased matrix metalloproteinase (MMP) activities, and its role in the pathogenesis of DR, the focus is now to apply effective strategies to prevent BM thickening to establish its therapeutic potential." @default.
- W3130488930 created "2021-03-01" @default.
- W3130488930 creator A5058361330 @default.
- W3130488930 creator A5085497567 @default.
- W3130488930 date "2021-01-01" @default.
- W3130488930 modified "2023-09-27" @default.
- W3130488930 title "Vascular Basement Membrane Thickening: Basis of Disease Pathology in Diabetic Retinopathy" @default.
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