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• W3130489784 abstract "Cholesterol is essential for cell physiology. Transport of the accessible pool of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) by ER-localized GRAMD1 proteins (GRAMD1a/1b/1c) contributes to cholesterol homeostasis. However, how cells detect accessible cholesterol within the PM remains unclear. We show that the GRAM domain of GRAMD1b, a coincidence detector for anionic lipids, including phosphatidylserine (PS), and cholesterol, possesses distinct but synergistic sites for sensing accessible cholesterol and anionic lipids. We find that a mutation within the GRAM domain of GRAMD1b that is associated with intellectual disability in humans specifically impairs cholesterol sensing. In addition, we identified another point mutation within this domain that enhances cholesterol sensitivity without altering its PS sensitivity. Cell-free reconstitution and cell-based assays revealed that the ability of the GRAM domain to sense accessible cholesterol regulates membrane tethering and determines the rate of cholesterol transport by GRAMD1b. Thus, cells detect the codistribution of accessible cholesterol and anionic lipids in the PM and fine-tune the non-vesicular transport of PM cholesterol to the ER via GRAMD1s." @default.
• W3130489784 created "2021-03-01" @default.
• W3130489784 creator A5019198817 @default.
• W3130489784 creator A5039772986 @default.
• W3130489784 creator A5047427629 @default.
• W3130489784 creator A5047455732 @default.
• W3130489784 creator A5061335959 @default.
• W3130489784 date "2021-02-19" @default.
• W3130489784 modified "2023-10-16" @default.
• W3130489784 title "Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b" @default.
• W3130489784 cites W1500080863 @default.
• W3130489784 cites W1527093201 @default.
• W3130489784 cites W1658011747 @default.
• W3130489784 cites W1852519544 @default.
• W3130489784 cites W1898232548 @default.
• W3130489784 cites W1916516745 @default.
• W3130489784 cites W1953389667 @default.
• W3130489784 cites W1973655670 @default.
• W3130489784 cites W1973728337 @default.
• W3130489784 cites W1975782237 @default.
• W3130489784 cites W1977222014 @default.
• W3130489784 cites W1982926925 @default.
• W3130489784 cites W1988838278 @default.
• W3130489784 cites W1999226878 @default.
• W3130489784 cites W1999292937 @default.
• W3130489784 cites W2011679829 @default.
• W3130489784 cites W2019351415 @default.
• W3130489784 cites W2024426605 @default.
• W3130489784 cites W2038815148 @default.
• W3130489784 cites W2043312574 @default.
• W3130489784 cites W2046138985 @default.
• W3130489784 cites W2049651968 @default.
• W3130489784 cites W2049705078 @default.
• W3130489784 cites W2053839044 @default.
• W3130489784 cites W2060224232 @default.
• W3130489784 cites W2063448502 @default.
• W3130489784 cites W2068749469 @default.
• W3130489784 cites W2071124826 @default.
• W3130489784 cites W2072024204 @default.
• W3130489784 cites W2082011949 @default.
• W3130489784 cites W2082426627 @default.
• W3130489784 cites W2086024671 @default.
• W3130489784 cites W2089037203 @default.
• W3130489784 cites W2092150552 @default.
• W3130489784 cites W2092258235 @default.
• W3130489784 cites W2096695240 @default.
• W3130489784 cites W2099133435 @default.
• W3130489784 cites W2101357408 @default.
• W3130489784 cites W2110679317 @default.
• W3130489784 cites W2113476159 @default.
• W3130489784 cites W2117810638 @default.
• W3130489784 cites W2125872855 @default.
• W3130489784 cites W2126835844 @default.
• W3130489784 cites W2128484647 @default.
• W3130489784 cites W2152114560 @default.
• W3130489784 cites W2157705248 @default.
• W3130489784 cites W2158266834 @default.
• W3130489784 cites W2160347316 @default.
• W3130489784 cites W2168974130 @default.
• W3130489784 cites W2169620068 @default.
• W3130489784 cites W2170885541 @default.
• W3130489784 cites W2182369134 @default.
• W3130489784 cites W2318022761 @default.
• W3130489784 cites W2553725030 @default.
• W3130489784 cites W2578320976 @default.
• W3130489784 cites W2586630646 @default.
• W3130489784 cites W2600192926 @default.
• W3130489784 cites W2606899102 @default.
• W3130489784 cites W2745669578 @default.
• W3130489784 cites W2777645466 @default.
• W3130489784 cites W2783556487 @default.
• W3130489784 cites W2787879899 @default.
• W3130489784 cites W2788633957 @default.
• W3130489784 cites W2788989831 @default.
• W3130489784 cites W2794677524 @default.
• W3130489784 cites W2807862414 @default.
• W3130489784 cites W2886012836 @default.
• W3130489784 cites W2888689224 @default.
• W3130489784 cites W2891007226 @default.
• W3130489784 cites W2896758254 @default.
• W3130489784 cites W2900182380 @default.
• W3130489784 cites W2904820355 @default.
• W3130489784 cites W2914180594 @default.
• W3130489784 cites W2937810045 @default.
• W3130489784 cites W2952439736 @default.
• W3130489784 cites W2964126164 @default.
• W3130489784 cites W2979346640 @default.
• W3130489784 cites W2984012077 @default.
• W3130489784 cites W2987979134 @default.
• W3130489784 cites W2991704999 @default.
• W3130489784 cites W3013477904 @default.
• W3130489784 cites W3013666444 @default.
• W3130489784 cites W3016916744 @default.
• W3130489784 cites W3042906013 @default.
• W3130489784 cites W3045552307 @default.
• W3130489784 cites W4255907729 @default.
• W3130489784 doi "https://doi.org/10.15252/embj.2020106524" @default.
• W3130489784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7957428" @default.
• W3130489784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33604931" @default.
• W3130489784 hasPublicationYear "2021" @default.

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