FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130490993> ?p ?o ?g. }

• W3130490993 endingPage "1482" @default.
• W3130490993 startingPage "1469" @default.
• W3130490993 abstract "In this study, we develop a computational model of the interaction between ryanodine receptor type 2 (RyR2) and calmodulin (CaM) to explore the mechanistic link between CaM-RyR2 interactions and cardiac arrhythmia. Our starting point is a biophysically based computational model of CaM binding to a single RyR2 subunit, which reproduces single-channel RyR2 measurements in lipid bilayers. We then integrate this CaM-RyR2 model into a spatially distributed whole-cell model of Ca cycling, which is used to investigate the relationship between CaM and Ca cycling homeostasis. We show that a reduction in CaM concentration leads to a substantial increase in the rate of spontaneous Ca sparks, and this induces a marked reduction in sarcoplasmic reticulum Ca load during steady-state pacing. Also, we show that a reduction in CaM modifies the RyR2 open probability, which makes the cell more prone to Ca wave propagation. These results indicate that aberrant Ca cycling activity during pacing is determined by the interplay between sarcoplasmic reticulum load reduction and the threshold for Ca wave propagation. Based on these results, we show that when CaM is reduced, Ca waves can occur in a cell and induce action potential perturbations that are arrhythmogenic. Thus, this study outlines a novel, to our knowledge, mechanistic link between CaM-RyR2 binding kinetics and the induction of arrhythmias in the heart." @default.
• W3130490993 created "2021-03-01" @default.
• W3130490993 creator A5044079903 @default.
• W3130490993 creator A5068949499 @default.
• W3130490993 date "2021-04-01" @default.
• W3130490993 modified "2023-10-15" @default.
• W3130490993 title "Mechanistic link between CaM-RyR2 interactions and the genesis of cardiac arrhythmia" @default.
• W3130490993 cites W1490746554 @default.
• W3130490993 cites W1764072566 @default.
• W3130490993 cites W1893636323 @default.
• W3130490993 cites W1969971056 @default.
• W3130490993 cites W1974171267 @default.
• W3130490993 cites W1983707293 @default.
• W3130490993 cites W1986387685 @default.
• W3130490993 cites W1997146045 @default.
• W3130490993 cites W2004986917 @default.
• W3130490993 cites W2020664968 @default.
• W3130490993 cites W2021630348 @default.
• W3130490993 cites W2040384409 @default.
• W3130490993 cites W2046993659 @default.
• W3130490993 cites W2048022581 @default.
• W3130490993 cites W2058970406 @default.
• W3130490993 cites W2062131013 @default.
• W3130490993 cites W2063557153 @default.
• W3130490993 cites W2068650437 @default.
• W3130490993 cites W2072719128 @default.
• W3130490993 cites W2080437238 @default.
• W3130490993 cites W2082547186 @default.
• W3130490993 cites W2083248130 @default.
• W3130490993 cites W2090362748 @default.
• W3130490993 cites W2095168948 @default.
• W3130490993 cites W2103400105 @default.
• W3130490993 cites W2106550370 @default.
• W3130490993 cites W2106972592 @default.
• W3130490993 cites W2112792367 @default.
• W3130490993 cites W2115812446 @default.
• W3130490993 cites W2116297568 @default.
• W3130490993 cites W2121722537 @default.
• W3130490993 cites W2130124702 @default.
• W3130490993 cites W2134895233 @default.
• W3130490993 cites W2142203228 @default.
• W3130490993 cites W2144742768 @default.
• W3130490993 cites W2154038686 @default.
• W3130490993 cites W2419423106 @default.
• W3130490993 cites W2514933645 @default.
• W3130490993 cites W2520922267 @default.
• W3130490993 cites W2523333069 @default.
• W3130490993 cites W2531345437 @default.
• W3130490993 cites W2774993157 @default.
• W3130490993 cites W2785591862 @default.
• W3130490993 cites W2792738008 @default.
• W3130490993 cites W2887821764 @default.
• W3130490993 cites W2953950496 @default.
• W3130490993 cites W2969057361 @default.
• W3130490993 cites W2995562244 @default.
• W3130490993 cites W4211145651 @default.
• W3130490993 cites W4233503959 @default.
• W3130490993 cites W4244267012 @default.
• W3130490993 doi "https://doi.org/10.1016/j.bpj.2021.02.016" @default.
• W3130490993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8105736" @default.
• W3130490993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33617831" @default.
• W3130490993 hasPublicationYear "2021" @default.
• W3130490993 type Work @default.
• W3130490993 sameAs 3130490993 @default.
• W3130490993 citedByCount "5" @default.
• W3130490993 countsByYear W31304909932022 @default.
• W3130490993 countsByYear W31304909932023 @default.
• W3130490993 crossrefType "journal-article" @default.
• W3130490993 hasAuthorship W3130490993A5044079903 @default.
• W3130490993 hasAuthorship W3130490993A5068949499 @default.
• W3130490993 hasBestOaLocation W31304909931 @default.
• W3130490993 hasConcept C113217602 @default.
• W3130490993 hasConcept C12554922 @default.
• W3130490993 hasConcept C158617107 @default.
• W3130490993 hasConcept C178790620 @default.
• W3130490993 hasConcept C185592680 @default.
• W3130490993 hasConcept C190712762 @default.
• W3130490993 hasConcept C29688787 @default.
• W3130490993 hasConcept C519063684 @default.
• W3130490993 hasConcept C55493867 @default.
• W3130490993 hasConcept C86803240 @default.
• W3130490993 hasConceptScore W3130490993C113217602 @default.
• W3130490993 hasConceptScore W3130490993C12554922 @default.
• W3130490993 hasConceptScore W3130490993C158617107 @default.
• W3130490993 hasConceptScore W3130490993C178790620 @default.
• W3130490993 hasConceptScore W3130490993C185592680 @default.
• W3130490993 hasConceptScore W3130490993C190712762 @default.
• W3130490993 hasConceptScore W3130490993C29688787 @default.
• W3130490993 hasConceptScore W3130490993C519063684 @default.
• W3130490993 hasConceptScore W3130490993C55493867 @default.
• W3130490993 hasConceptScore W3130490993C86803240 @default.
• W3130490993 hasIssue "8" @default.
• W3130490993 hasLocation W31304909931 @default.
• W3130490993 hasLocation W31304909932 @default.
• W3130490993 hasLocation W31304909933 @default.
• W3130490993 hasOpenAccess W3130490993 @default.
• W3130490993 hasPrimaryLocation W31304909931 @default.
• W3130490993 hasRelatedWork W1965719501 @default.

• next