FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130536504> ?p ?o ?g. }

• W3130536504 endingPage "L784" @default.
• W3130536504 startingPage "L770" @default.
• W3130536504 abstract "Gestational long-term hypoxia increases the risk of myriad diseases in infants including persistent pulmonary hypertension. Similar to humans, fetal lamb lung development is susceptible to long-term intrauterine hypoxia, with structural and functional changes associated with the development of pulmonary hypertension including pulmonary arterial medial wall thickening and dysregulation of arterial reactivity, which culminates in decreased right ventricular output. To further explore the mechanisms associated with hypoxia-induced aberrations in the fetal sheep lung, we examined the premise that metabolomic changes and functional phenotypic transformations occur due to intrauterine, long-term hypoxia. To address this, we performed electron microscopy, Western immunoblotting, calcium imaging, and metabolomic analyses on pulmonary arteries isolated from near-term fetal lambs that had been exposed to low- or high-altitude (3,801 m) hypoxia for the latter 110+ days of gestation. Our results demonstrate that the sarcoplasmic reticulum was swollen with high luminal width and distances to the plasma membrane in the hypoxic group. Hypoxic animals were presented with higher endoplasmic reticulum stress and suppressed calcium storage. Metabolically, hypoxia was associated with lower levels of multiple omega-3 polyunsaturated fatty acids and derived lipid mediators (e.g., eicosapentaenoic acid, docosahexaenoic acid, α-linolenic acid, 5-hydroxyeicosapentaenoic acid (5-HEPE), 12-HEPE, 15-HEPE, prostaglandin E3, and 19(20)-epoxy docosapentaenoic acid) and higher levels of some omega-6 metabolites ( P < 0.02) including 15-keto prostaglandin E2 and linoleoylglycerol. Collectively, the results reveal broad evidence for long-term hypoxia-induced metabolic reprogramming and phenotypic transformations in the pulmonary arteries of fetal sheep, conditions that likely contribute to the development of persistent pulmonary hypertension." @default.
• W3130536504 created "2021-03-01" @default.
• W3130536504 creator A5003198184 @default.
• W3130536504 creator A5014879392 @default.
• W3130536504 creator A5017624762 @default.
• W3130536504 creator A5020366548 @default.
• W3130536504 creator A5023335489 @default.
• W3130536504 creator A5030268064 @default.
• W3130536504 creator A5033110589 @default.
• W3130536504 creator A5038799103 @default.
• W3130536504 creator A5046519553 @default.
• W3130536504 creator A5056119662 @default.
• W3130536504 creator A5066716873 @default.
• W3130536504 creator A5068389319 @default.
• W3130536504 creator A5069102417 @default.
• W3130536504 creator A5074751581 @default.
• W3130536504 creator A5078570032 @default.
• W3130536504 creator A5081447009 @default.
• W3130536504 creator A5085030272 @default.
• W3130536504 creator A5087349635 @default.
• W3130536504 date "2021-05-01" @default.
• W3130536504 modified "2023-10-16" @default.
• W3130536504 title "Gestational long-term hypoxia induces metabolomic reprogramming and phenotypic transformations in fetal sheep pulmonary arteries" @default.
• W3130536504 cites W1493743506 @default.
• W3130536504 cites W1537125811 @default.
• W3130536504 cites W1902636525 @default.
• W3130536504 cites W1960974681 @default.
• W3130536504 cites W1969018680 @default.
• W3130536504 cites W1971110044 @default.
• W3130536504 cites W1972633518 @default.
• W3130536504 cites W1980073162 @default.
• W3130536504 cites W1982178416 @default.
• W3130536504 cites W1983737745 @default.
• W3130536504 cites W1990398886 @default.
• W3130536504 cites W1999623479 @default.
• W3130536504 cites W2001540049 @default.
• W3130536504 cites W2004656052 @default.
• W3130536504 cites W2007259227 @default.
• W3130536504 cites W2012151074 @default.
• W3130536504 cites W2019402080 @default.
• W3130536504 cites W2023858783 @default.
• W3130536504 cites W2047842408 @default.
• W3130536504 cites W2048652290 @default.
• W3130536504 cites W2050112422 @default.
• W3130536504 cites W2067352199 @default.
• W3130536504 cites W2071142366 @default.
• W3130536504 cites W2072964410 @default.
• W3130536504 cites W2082662353 @default.
• W3130536504 cites W2087408461 @default.
• W3130536504 cites W2096909501 @default.
• W3130536504 cites W2106716373 @default.
• W3130536504 cites W2107358582 @default.
• W3130536504 cites W2109701978 @default.
• W3130536504 cites W2110065044 @default.
• W3130536504 cites W2111370164 @default.
• W3130536504 cites W2129974335 @default.
• W3130536504 cites W2131054894 @default.
• W3130536504 cites W2132099507 @default.
• W3130536504 cites W2141054679 @default.
• W3130536504 cites W2142002201 @default.
• W3130536504 cites W2151685833 @default.
• W3130536504 cites W2169616927 @default.
• W3130536504 cites W2171254221 @default.
• W3130536504 cites W2183079322 @default.
• W3130536504 cites W2188392465 @default.
• W3130536504 cites W2226815533 @default.
• W3130536504 cites W2282298143 @default.
• W3130536504 cites W2298233501 @default.
• W3130536504 cites W2319036533 @default.
• W3130536504 cites W2371144936 @default.
• W3130536504 cites W2399426549 @default.
• W3130536504 cites W2520222164 @default.
• W3130536504 cites W2548991753 @default.
• W3130536504 cites W2587551638 @default.
• W3130536504 cites W2612498214 @default.
• W3130536504 cites W2728536122 @default.
• W3130536504 cites W2766501219 @default.
• W3130536504 cites W2768198542 @default.
• W3130536504 cites W2768555383 @default.
• W3130536504 cites W2773645177 @default.
• W3130536504 cites W2791566446 @default.
• W3130536504 cites W2793204168 @default.
• W3130536504 cites W2801127590 @default.
• W3130536504 cites W2803664483 @default.
• W3130536504 cites W2886083365 @default.
• W3130536504 cites W2909224188 @default.
• W3130536504 cites W2915043132 @default.
• W3130536504 cites W2922202142 @default.
• W3130536504 cites W2925318743 @default.
• W3130536504 cites W2939994314 @default.
• W3130536504 cites W2964851853 @default.
• W3130536504 cites W2995525529 @default.
• W3130536504 cites W3014512422 @default.
• W3130536504 cites W3042882701 @default.
• W3130536504 cites W774391212 @default.
• W3130536504 doi "https://doi.org/10.1152/ajplung.00469.2020" @default.
• W3130536504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8174832" @default.
• W3130536504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33624555" @default.

• next