Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130538696> ?p ?o ?g. }
- W3130538696 abstract "ABSTRACT Motile cilia defects impair cerebrospinal fluid (CSF) flow, and can cause brain and spine disorders. To date, the development of ciliated cells, their impact on CSF flow and their function in brain and axial morphogenesis are not fully understood. Here, we have characterized motile ciliated cells within the zebrafish brain ventricles. We show that the ventricular surface undergoes significant restructuring through development, involving a transition from mono- to multiciliated cells (MCCs) driven by gmnc. MCCs are translationally polarized, co-exist with monociliated cells and generate directional flow patterns. Moreover, these ciliated cells have different developmental origins, and are genetically heterogenous with respect to expression of the Foxj1 family of ciliary master regulators. Finally, we show that cilia loss from specific brain regions or global perturbation of multiciliation does not affect overall brain or spine morphogenesis, but results in enlarged ventricles. Our findings establish that motile ciliated cells are generated by complementary and sequential transcriptional programs to support ventricular development." @default.
- W3130538696 created "2021-03-01" @default.
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- W3130538696 date "2021-02-17" @default.
- W3130538696 modified "2023-10-17" @default.
- W3130538696 title "Diversity and Function of Motile Ciliated Cell Types within Ependymal Lineages of the Zebrafish Brain" @default.
- W3130538696 cites W1588994353 @default.
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- W3130538696 cites W1938714998 @default.
- W3130538696 cites W1948659683 @default.
- W3130538696 cites W1965051030 @default.
- W3130538696 cites W1966242446 @default.
- W3130538696 cites W1969182723 @default.
- W3130538696 cites W1987283412 @default.
- W3130538696 cites W1993028307 @default.
- W3130538696 cites W1994157744 @default.
- W3130538696 cites W1997624362 @default.
- W3130538696 cites W2001245581 @default.
- W3130538696 cites W2005739964 @default.
- W3130538696 cites W2011855956 @default.
- W3130538696 cites W2013269126 @default.
- W3130538696 cites W2013469097 @default.
- W3130538696 cites W2016607788 @default.
- W3130538696 cites W2022311164 @default.
- W3130538696 cites W2025004171 @default.
- W3130538696 cites W2026598324 @default.
- W3130538696 cites W2035675733 @default.
- W3130538696 cites W2036582717 @default.
- W3130538696 cites W2046700572 @default.
- W3130538696 cites W2047678214 @default.
- W3130538696 cites W2050121841 @default.
- W3130538696 cites W2058525645 @default.
- W3130538696 cites W2061944004 @default.
- W3130538696 cites W2062017597 @default.
- W3130538696 cites W2076420955 @default.
- W3130538696 cites W2077614233 @default.
- W3130538696 cites W2079891083 @default.
- W3130538696 cites W2084609008 @default.
- W3130538696 cites W2103344845 @default.
- W3130538696 cites W2104520647 @default.
- W3130538696 cites W2109838864 @default.
- W3130538696 cites W2109839465 @default.
- W3130538696 cites W2120455375 @default.
- W3130538696 cites W2145435031 @default.
- W3130538696 cites W2151843654 @default.
- W3130538696 cites W2156354373 @default.
- W3130538696 cites W2164198809 @default.
- W3130538696 cites W2166572577 @default.
- W3130538696 cites W2167279371 @default.
- W3130538696 cites W2187684510 @default.
- W3130538696 cites W2253906470 @default.
- W3130538696 cites W2289824882 @default.
- W3130538696 cites W2301681399 @default.
- W3130538696 cites W2416325988 @default.
- W3130538696 cites W2468900482 @default.
- W3130538696 cites W2474653353 @default.
- W3130538696 cites W2529052661 @default.
- W3130538696 cites W2538431692 @default.
- W3130538696 cites W2561670917 @default.
- W3130538696 cites W2582033455 @default.
- W3130538696 cites W2588828521 @default.
- W3130538696 cites W2606745140 @default.
- W3130538696 cites W2612010903 @default.
- W3130538696 cites W2743273516 @default.
- W3130538696 cites W2778987076 @default.
- W3130538696 cites W2787246109 @default.
- W3130538696 cites W2802670298 @default.
- W3130538696 cites W2883339193 @default.
- W3130538696 cites W2890558202 @default.
- W3130538696 cites W2898810121 @default.
- W3130538696 cites W2902294412 @default.
- W3130538696 cites W2908047046 @default.
- W3130538696 cites W2916811543 @default.
- W3130538696 cites W2938203832 @default.
- W3130538696 cites W2939870752 @default.
- W3130538696 cites W2942040271 @default.
- W3130538696 cites W2949649718 @default.
- W3130538696 cites W2950075092 @default.
- W3130538696 cites W2950720790 @default.
- W3130538696 cites W2951543620 @default.
- W3130538696 cites W2951555881 @default.
- W3130538696 cites W2963509320 @default.
- W3130538696 cites W2969719419 @default.