Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130607488> ?p ?o ?g. }
- W3130607488 endingPage "158" @default.
- W3130607488 startingPage "158" @default.
- W3130607488 abstract "To develop novel 99mTc-labeled single-photon emission computed tomography (SPECT) radiotracers for imaging hypoxia, a novel HYNICNM ligand (6-hydrazinonicotinamide (HYNIC) 2-nitroimidazole derivative) was designed and synthesized. It was radiolabeled with technetium-99m using tricine/trisodium triphenylphosphine-3,3′,3′′-trisulfonate (TPPTS), tricine/sodium triphenylphosphine-3-monosulfonate (TPPMS) and tricine as co-ligands to obtain [99mTc]Tc-tricine-TPPTS-HYNICNM, [99mTc]Tc-tricine-TPPMS-HYNICNM, and [99mTc]Tc-(tricine)2-HYNICNM, respectively. The three technetium-99m complexes were radiolabeled in one step with a high yield (95%) and had good stability in saline and mouse serum. In vitro cellular uptake results showed that these complexes exhibited good hypoxic selectivity. The partition coefficient indicated that they were good hydrophilic complexes, and [99mTc]Tc-tricine-TPPTS-HYNICNM displayed the highest hydrophilicity (−3.02 ± 0.08). The biodistribution in mice bearing S180 tumors showed that [99mTc]Tc-tricine-TPPTS-HYNICNM exhibited higher tumor uptake (1.05 ± 0.27% IA/g); more rapid clearance from the liver, blood, muscle, and other non-target organs; and a higher tumor/non-target ratio, especially for the tumor/liver ratio (1.95), than [99mTc]Tc-tricine-TPPMS-HYNICNM and [99mTc]Tc-(tricine)2-HYNICNM. The results of single-photon emission computed tomography (SPECT) imaging studies of [99mTc]Tc-tricine-TPPTS-HYNICNM were in accordance with the biodistribution results, which suggested that [99mTc]Tc-tricine-TPPTS-HYNICNM is a promising agent for imaging tumor hypoxia." @default.
- W3130607488 created "2021-03-01" @default.
- W3130607488 creator A5015767701 @default.
- W3130607488 creator A5017594071 @default.
- W3130607488 creator A5022017147 @default.
- W3130607488 creator A5068548487 @default.
- W3130607488 creator A5087854367 @default.
- W3130607488 date "2021-02-15" @default.
- W3130607488 modified "2023-10-05" @default.
- W3130607488 title "Preparation and Bioevaluation of Novel 99mTc-Labeled Complexes with a 2-Nitroimidazole HYNIC Derivative for Imaging Tumor Hypoxia" @default.
- W3130607488 cites W111589645 @default.
- W3130607488 cites W1553997414 @default.
- W3130607488 cites W1965587700 @default.
- W3130607488 cites W1997424061 @default.
- W3130607488 cites W2001348339 @default.
- W3130607488 cites W2002642967 @default.
- W3130607488 cites W2008283713 @default.
- W3130607488 cites W2013436421 @default.
- W3130607488 cites W2020704258 @default.
- W3130607488 cites W2024903578 @default.
- W3130607488 cites W2031715301 @default.
- W3130607488 cites W2034525976 @default.
- W3130607488 cites W2043536053 @default.
- W3130607488 cites W2044819093 @default.
- W3130607488 cites W2049655755 @default.
- W3130607488 cites W2063040188 @default.
- W3130607488 cites W2083083625 @default.
- W3130607488 cites W2086456641 @default.
- W3130607488 cites W2091755098 @default.
- W3130607488 cites W2092275219 @default.
- W3130607488 cites W2093988815 @default.
- W3130607488 cites W2097598171 @default.
- W3130607488 cites W2129852620 @default.
- W3130607488 cites W2144691220 @default.
- W3130607488 cites W2172893418 @default.
- W3130607488 cites W2195222776 @default.
- W3130607488 cites W2313787631 @default.
- W3130607488 cites W2473759577 @default.
- W3130607488 cites W2577593852 @default.
- W3130607488 cites W2605220478 @default.
- W3130607488 cites W2774018970 @default.
- W3130607488 cites W2801054688 @default.
- W3130607488 cites W2851907692 @default.
- W3130607488 cites W2887033958 @default.
- W3130607488 cites W2887292578 @default.
- W3130607488 cites W2921921390 @default.
- W3130607488 cites W2940011254 @default.
- W3130607488 cites W2982183600 @default.
- W3130607488 cites W2997842048 @default.
- W3130607488 cites W3006805218 @default.
- W3130607488 cites W3011367086 @default.
- W3130607488 cites W3025787802 @default.
- W3130607488 cites W3081448065 @default.
- W3130607488 cites W2911713377 @default.
- W3130607488 doi "https://doi.org/10.3390/ph14020158" @default.
- W3130607488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7919024" @default.
- W3130607488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33671923" @default.
- W3130607488 hasPublicationYear "2021" @default.
- W3130607488 type Work @default.
- W3130607488 sameAs 3130607488 @default.
- W3130607488 citedByCount "5" @default.
- W3130607488 countsByYear W31306074882022 @default.
- W3130607488 countsByYear W31306074882023 @default.
- W3130607488 crossrefType "journal-article" @default.
- W3130607488 hasAuthorship W3130607488A5015767701 @default.
- W3130607488 hasAuthorship W3130607488A5017594071 @default.
- W3130607488 hasAuthorship W3130607488A5022017147 @default.
- W3130607488 hasAuthorship W3130607488A5068548487 @default.
- W3130607488 hasAuthorship W3130607488A5087854367 @default.
- W3130607488 hasBestOaLocation W31306074881 @default.
- W3130607488 hasConcept C100805817 @default.
- W3130607488 hasConcept C13965031 @default.
- W3130607488 hasConcept C150903083 @default.
- W3130607488 hasConcept C161790260 @default.
- W3130607488 hasConcept C185592680 @default.
- W3130607488 hasConcept C202751555 @default.
- W3130607488 hasConcept C207001950 @default.
- W3130607488 hasConcept C2775974274 @default.
- W3130607488 hasConcept C2777807558 @default.
- W3130607488 hasConcept C2778172261 @default.
- W3130607488 hasConcept C2779211555 @default.
- W3130607488 hasConcept C521398313 @default.
- W3130607488 hasConcept C522557706 @default.
- W3130607488 hasConcept C55493867 @default.
- W3130607488 hasConcept C86803240 @default.
- W3130607488 hasConceptScore W3130607488C100805817 @default.
- W3130607488 hasConceptScore W3130607488C13965031 @default.
- W3130607488 hasConceptScore W3130607488C150903083 @default.
- W3130607488 hasConceptScore W3130607488C161790260 @default.
- W3130607488 hasConceptScore W3130607488C185592680 @default.
- W3130607488 hasConceptScore W3130607488C202751555 @default.
- W3130607488 hasConceptScore W3130607488C207001950 @default.
- W3130607488 hasConceptScore W3130607488C2775974274 @default.
- W3130607488 hasConceptScore W3130607488C2777807558 @default.
- W3130607488 hasConceptScore W3130607488C2778172261 @default.
- W3130607488 hasConceptScore W3130607488C2779211555 @default.
- W3130607488 hasConceptScore W3130607488C521398313 @default.
- W3130607488 hasConceptScore W3130607488C522557706 @default.