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- W3130713278 abstract "Mortality of cancer is the result of regional and/or systemic metastasis. Matrix metalloproteinases (MMPs) were believed to play an important role in its malignant behavior. MMPs have been identified as matrix-degrading enzymes, such as procollagenase (proMMP-1) of Mr=53, 000, progelatinase (proMMP-2) of Mr=72, 000 and proMMP-9 of Mr=92, 000, and prostromelysin (proMMP-3) of Mr=59, 000. The regulatory mechanism of these enzymes is still unclear; however, it has been indicated that many growth factors such as EGF, TGF-α, TGF-β, PDGF, and etc. will play an important role in MMPs synthesis of cancer cells.In this paper, we report that two oral cell lines of squamous cell carcinoma (SCC9 and SCC25) produce at least two types of MMPs, which have been identified as proMMP-2 and 3 by the indirect immunofluorescence technique, immunoblot analysis, and gelatin-substrate gel zymography. Additionally, a 92-kDa gelatinolytic metalloproteinase was detected in SCC25 by gelatin-substrate gel zymography. Furthermore, after the treatment with EGF, the production of proMMP-1 and 3 by SCC25 was increased in a dose-dependent manner, but not by SCC9. However, unlike EGF, TGF-β stimulated both cell lines to produce proMMP-2. These results suggest that oral carcinoma cells have a potential to degrade extracellular matrix macromolecules including basement membrane components, and EGF and TGF-β are important factors for influencing the metastatic potential of oral squamous cell carcinomas." @default.
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- W3130713278 date "1992-01-01" @default.
- W3130713278 modified "2023-10-16" @default.
- W3130713278 title "Oral cancer and matrix metalloproteinases. I. The expression of matrix metalloproteinases in cultured oral squamous cell carcinoma and the effects of growth factors on their production." @default.
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- W3130713278 doi "https://doi.org/10.5794/jjoms.38.567" @default.
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