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- W3130744878 abstract "Objective: Methicillin-resistant Staphylococcus aureus (MRSA) ST8-t008 of the pulsotype USA300 and the Latin American variant (USA300-LV) are the predominant virulent MRSA clonal lineages on the American continent. In Europe, the occurrence of USA300 or USA300-LV has often been related to international travel or outbreaks in hospitals. The replacement of local epidemic MRSA clones by these hypervirulent clones has not yet been demonstrated in Europe. This study aimed to gain insight into the genetic relatedness of ST8-t008 MRSA encountered in previous studies in the Rhine-Neckar Region, Germany, and ST8-t008 MRSA from other geographic regions. Methods: Nineteen ST8-t008 MRSA isolated between 2012 and 2018 were compared with publicly available sequences of ST8-t008 MRSA from travellers returning from the tropics, and USA300 and USA300-LV that were previously encountered in Europe. Results: We identified 14 of 19 (73.7%) of the local ST8-t008 MRSA being related to USA300 and five of 19 (26.3%) belonging to the USA300-LV cluster. Four suspected transmission clusters were identified without any evidence of in-hospital transmission. Conclusion: The genetic relatedness of these local strains to publicly available sequences of ST8-t008 MRSA from other parts of Europe and to MRSA of travellers returning from the tropics pointed to multiple introductions into Germany. However, four suspected transmission clusters may be an indication of transmission within the community." @default.
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- W3130744878 date "2021-04-01" @default.
- W3130744878 modified "2023-09-26" @default.
- W3130744878 title "Genomic structure of ST8-t008 USA300 and USA300-LV MRSA in the Rhine-Neckar Region, Germany, 2012–2018" @default.
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- W3130744878 doi "https://doi.org/10.1016/j.ijantimicag.2021.106312" @default.
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