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- W3130750280 abstract "Fibrin forms a web-like network made of fibers that act as the primary structural component in blood clots. When a blood clot is no longer needed, fibrin networks are digested by the enzyme plasmin in a process called fibrinolysis. We studied the lysis of individual fibrin fibers using fluorescence microscopy. Our results indicate that the inherent tension in fibers contributes to the lysis of individual fibers. Moreover, we show that plasmin digestion occurs at multiple locations along the fiber until one location is fully transected across the entire fiber diameter. These results help to advance a longstanding debate about whether fibers are uniformly digested radially, with plasmin evenly spread down the length of a fiber, or whether plasmin is concentrated at a single point on a fibrin fiber, where a distinct transverse cleavage occurs. An accurate model for the digestion of fibrin fibers by plasmin would aid in our understanding of blood clot degradation under various therapeutic conditions. We present a preliminary model of plasmin-initiated fibrinolysis as a first step toward this goal." @default.
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- W3130750280 date "2021-02-01" @default.
- W3130750280 modified "2023-09-28" @default.
- W3130750280 title "Resolving Structural Changes in Fibers during Fibrinolysis" @default.
- W3130750280 doi "https://doi.org/10.1016/j.bpj.2020.11.1417" @default.
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