Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130751336> ?p ?o ?g. }
- W3130751336 endingPage "813" @default.
- W3130751336 startingPage "801" @default.
- W3130751336 abstract "Abstract Many integrins transmit signals through global conformational changes. However, it is unclear whether integrin α v β 8 adopts a similar mechanism during integrin activation and signaling on the cell surface. Here, we showed that disulfide‐bonded mutants, which prevented integrin α v β 8 lower leg dissociation, bound ligands with similar level as the wild‐type protein, suggesting that α v β 8 ligand binding did not require lower leg disassociation. We further showed that the N‐glycosylation mutant at the interface between the β I and hybrid domains did not affect ligand binding, suggesting that the α v β 8 open headpiece was not present on the cell surface. We proposed that α v β 8 integrin may adopt only one state, that is, the extended conformation with a closed headpiece. Our results showed that two lower legs retained heterodimeric interfaces, and this association might be important for stabilizing integrin in the extended conformation. Therefore, α v β 8 may not transmit bidirectional signals across the plasma membrane but instead may serve as an anchoring site with high affinity and high accessibility for extracellular ligands." @default.
- W3130751336 created "2021-03-01" @default.
- W3130751336 creator A5042822650 @default.
- W3130751336 creator A5062947234 @default.
- W3130751336 date "2021-02-22" @default.
- W3130751336 modified "2023-10-01" @default.
- W3130751336 title "Effects of the association of the α <sub>v</sub> β <sub>8</sub> lower legs on integrin ligand binding" @default.
- W3130751336 cites W1561903693 @default.
- W3130751336 cites W1576773659 @default.
- W3130751336 cites W1931073059 @default.
- W3130751336 cites W1938388466 @default.
- W3130751336 cites W1973800056 @default.
- W3130751336 cites W1987589505 @default.
- W3130751336 cites W2003676289 @default.
- W3130751336 cites W2016464728 @default.
- W3130751336 cites W2026804025 @default.
- W3130751336 cites W2038692329 @default.
- W3130751336 cites W2040379229 @default.
- W3130751336 cites W2046623422 @default.
- W3130751336 cites W2047012860 @default.
- W3130751336 cites W2058952638 @default.
- W3130751336 cites W2065921660 @default.
- W3130751336 cites W2067595988 @default.
- W3130751336 cites W2083100745 @default.
- W3130751336 cites W2086996769 @default.
- W3130751336 cites W2094469836 @default.
- W3130751336 cites W2098438673 @default.
- W3130751336 cites W2099801792 @default.
- W3130751336 cites W2100773611 @default.
- W3130751336 cites W2102376680 @default.
- W3130751336 cites W2108496308 @default.
- W3130751336 cites W2111803487 @default.
- W3130751336 cites W2118462075 @default.
- W3130751336 cites W2122505281 @default.
- W3130751336 cites W2126164549 @default.
- W3130751336 cites W2131717149 @default.
- W3130751336 cites W2141643986 @default.
- W3130751336 cites W2144222001 @default.
- W3130751336 cites W2145680582 @default.
- W3130751336 cites W2147000598 @default.
- W3130751336 cites W2156293127 @default.
- W3130751336 cites W2160696686 @default.
- W3130751336 cites W2312632884 @default.
- W3130751336 cites W2319864754 @default.
- W3130751336 cites W2326911192 @default.
- W3130751336 cites W2555957081 @default.
- W3130751336 cites W2581552677 @default.
- W3130751336 cites W2582355481 @default.
- W3130751336 cites W2605519143 @default.
- W3130751336 cites W2613485520 @default.
- W3130751336 cites W2765322245 @default.
- W3130751336 cites W2768023356 @default.
- W3130751336 cites W2803109941 @default.
- W3130751336 cites W2806027443 @default.
- W3130751336 cites W2884564748 @default.
- W3130751336 cites W2897748857 @default.
- W3130751336 cites W2898513675 @default.
- W3130751336 cites W2901253067 @default.
- W3130751336 cites W2915478900 @default.
- W3130751336 cites W2944468828 @default.
- W3130751336 cites W2999601571 @default.
- W3130751336 cites W3003112303 @default.
- W3130751336 cites W3017416850 @default.
- W3130751336 cites W3025819722 @default.
- W3130751336 cites W3027314750 @default.
- W3130751336 doi "https://doi.org/10.1002/jcb.29912" @default.
- W3130751336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33619784" @default.
- W3130751336 hasPublicationYear "2021" @default.
- W3130751336 type Work @default.
- W3130751336 sameAs 3130751336 @default.
- W3130751336 citedByCount "2" @default.
- W3130751336 countsByYear W31307513362022 @default.
- W3130751336 crossrefType "journal-article" @default.
- W3130751336 hasAuthorship W3130751336A5042822650 @default.
- W3130751336 hasAuthorship W3130751336A5062947234 @default.
- W3130751336 hasConcept C104317684 @default.
- W3130751336 hasConcept C107824862 @default.
- W3130751336 hasConcept C116569031 @default.
- W3130751336 hasConcept C12554922 @default.
- W3130751336 hasConcept C143065580 @default.
- W3130751336 hasConcept C1491633281 @default.
- W3130751336 hasConcept C156585808 @default.
- W3130751336 hasConcept C170493617 @default.
- W3130751336 hasConcept C185592680 @default.
- W3130751336 hasConcept C195687474 @default.
- W3130751336 hasConcept C4894155 @default.
- W3130751336 hasConcept C55493867 @default.
- W3130751336 hasConcept C86803240 @default.
- W3130751336 hasConcept C95444343 @default.
- W3130751336 hasConceptScore W3130751336C104317684 @default.
- W3130751336 hasConceptScore W3130751336C107824862 @default.
- W3130751336 hasConceptScore W3130751336C116569031 @default.
- W3130751336 hasConceptScore W3130751336C12554922 @default.
- W3130751336 hasConceptScore W3130751336C143065580 @default.
- W3130751336 hasConceptScore W3130751336C1491633281 @default.
- W3130751336 hasConceptScore W3130751336C156585808 @default.
- W3130751336 hasConceptScore W3130751336C170493617 @default.
- W3130751336 hasConceptScore W3130751336C185592680 @default.