Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130767498> ?p ?o ?g. }
- W3130767498 endingPage "12" @default.
- W3130767498 startingPage "12" @default.
- W3130767498 abstract "This short note presents previous research data supporting a pilot study of metronomic dapsone during the entire course of glioblastoma treatment. The reviewed data indicate that neutrophils are an integral part of human glioblastoma pathophysiology, contributing to or facilitating glioblastoma growth and treatment resistance. Neutrophils collect within glioblastoma by chemotaxis along several chemokine/cytokine gradients, prominently among which is interleukin-8. Old data from dermatology research has shown that the old and inexpensive generic drug dapsone inhibits neutrophils' chemotaxis along interleukin-8 gradients. It is on that basis that dapsone is used to treat neutrophilic dermatoses, for example, dermatitis herpetiformis, bullous pemphigoid, erlotinib-related rash, and others. The hypothesis of this paper is that dapsone will reduce glioblastomas' neutrophil accumulations by the same mechanisms by which it reduces dermal neutrophil accumulations in the neutrophilic dermatoses. Dapsone would thereby reduce neutrophils' contributions to glioblastoma growth. Dapsone is not an ideal drug, however. It generates methemoglobinemia that occasionally is symptomatic. This generation is reduced by concomitant use of the antacid drug cimetidine. Given the uniform lethality of glioblastoma as of 2020, the risks of dapsone 100 mg twice daily and cimetidine 400 mg twice daily is low enough to warrant a judicious pilot study." @default.
- W3130767498 created "2021-03-01" @default.
- W3130767498 creator A5016608605 @default.
- W3130767498 date "2021-02-16" @default.
- W3130767498 modified "2023-09-25" @default.
- W3130767498 title "Research Supporting a Pilot Study of Metronomic Dapsone during Glioblastoma Chemoirradiation" @default.
- W3130767498 cites W1540368941 @default.
- W3130767498 cites W166298509 @default.
- W3130767498 cites W1940853629 @default.
- W3130767498 cites W1967482453 @default.
- W3130767498 cites W1980273002 @default.
- W3130767498 cites W1985636734 @default.
- W3130767498 cites W1987392047 @default.
- W3130767498 cites W1994444191 @default.
- W3130767498 cites W2003656051 @default.
- W3130767498 cites W2015143684 @default.
- W3130767498 cites W2026466512 @default.
- W3130767498 cites W2027474877 @default.
- W3130767498 cites W2034756726 @default.
- W3130767498 cites W2035596427 @default.
- W3130767498 cites W2045782733 @default.
- W3130767498 cites W2067705652 @default.
- W3130767498 cites W2082725895 @default.
- W3130767498 cites W2085495654 @default.
- W3130767498 cites W2094805343 @default.
- W3130767498 cites W2095239303 @default.
- W3130767498 cites W2095710461 @default.
- W3130767498 cites W2104527459 @default.
- W3130767498 cites W2115597075 @default.
- W3130767498 cites W2117826016 @default.
- W3130767498 cites W2122741606 @default.
- W3130767498 cites W2128748544 @default.
- W3130767498 cites W2135034215 @default.
- W3130767498 cites W2138652650 @default.
- W3130767498 cites W2151760337 @default.
- W3130767498 cites W2157012576 @default.
- W3130767498 cites W2164871149 @default.
- W3130767498 cites W2166618939 @default.
- W3130767498 cites W2168100290 @default.
- W3130767498 cites W2206466303 @default.
- W3130767498 cites W2220756562 @default.
- W3130767498 cites W2264139795 @default.
- W3130767498 cites W2306651097 @default.
- W3130767498 cites W2326769799 @default.
- W3130767498 cites W2340275561 @default.
- W3130767498 cites W2404152759 @default.
- W3130767498 cites W2490669401 @default.
- W3130767498 cites W2510345104 @default.
- W3130767498 cites W2521854992 @default.
- W3130767498 cites W2534106602 @default.
- W3130767498 cites W2579357075 @default.
- W3130767498 cites W2605650273 @default.
- W3130767498 cites W2736127847 @default.
- W3130767498 cites W2739998491 @default.
- W3130767498 cites W2744322172 @default.
- W3130767498 cites W2745320743 @default.
- W3130767498 cites W2756140984 @default.
- W3130767498 cites W2765824415 @default.
- W3130767498 cites W2766566317 @default.
- W3130767498 cites W2766685632 @default.
- W3130767498 cites W2766858078 @default.
- W3130767498 cites W2771876187 @default.
- W3130767498 cites W2786227974 @default.
- W3130767498 cites W2792374303 @default.
- W3130767498 cites W2797891654 @default.
- W3130767498 cites W2886743609 @default.
- W3130767498 cites W2887071740 @default.
- W3130767498 cites W2891101213 @default.
- W3130767498 cites W2892121274 @default.
- W3130767498 cites W2896788268 @default.
- W3130767498 cites W2899252841 @default.
- W3130767498 cites W2900254393 @default.
- W3130767498 cites W2905037161 @default.
- W3130767498 cites W2906111042 @default.
- W3130767498 cites W2916635720 @default.
- W3130767498 cites W2918622468 @default.
- W3130767498 cites W2922290126 @default.
- W3130767498 cites W2924613983 @default.
- W3130767498 cites W2925129680 @default.
- W3130767498 cites W2942016059 @default.
- W3130767498 cites W2944434178 @default.
- W3130767498 cites W2951559215 @default.
- W3130767498 cites W2954317599 @default.
- W3130767498 cites W2958451884 @default.
- W3130767498 cites W2963543514 @default.
- W3130767498 cites W2970645924 @default.
- W3130767498 cites W2972587227 @default.
- W3130767498 cites W2980625907 @default.
- W3130767498 cites W2980806941 @default.
- W3130767498 cites W2997739400 @default.
- W3130767498 cites W2999356769 @default.
- W3130767498 cites W3002714160 @default.
- W3130767498 cites W3011177832 @default.
- W3130767498 cites W3012066766 @default.
- W3130767498 cites W3020045638 @default.
- W3130767498 cites W3036991538 @default.
- W3130767498 cites W3037351834 @default.
- W3130767498 cites W3037876051 @default.