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• W3130789778 startingPage "127861" @default.
• W3130789778 abstract "Toll-like receptors (TLRs) play key role in innate immune response to Damage Associated Molecular Patterns (DAMPs) and Pathogen Associated Molecular Patterns (PAMPs). DAMP/PAMP-mediated activation of TLRs triggers NFκB signaling resulting in pro-inflammatory cytokine release. Using TLR2-Pam2CSK4 agonist co-crystal structure information, we designed and synthesized a novel series of Toll-like Receptor 2 (TLR2) lipid antagonists and identified compounds 14, 15 and 17 with sub-micromolar potency. TLR2 antagonists that we identified are stable for > 1.0 h in both gastric juice and PBS buffer and could be used as research tools." @default.
• W3130789778 created "2021-03-01" @default.
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• W3130789778 date "2021-05-01" @default.
• W3130789778 modified "2023-10-10" @default.
• W3130789778 title "Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists" @default.
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• W3130789778 doi "https://doi.org/10.1016/j.bmcl.2021.127861" @default.
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