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- W3130791339 endingPage "111464" @default.
- W3130791339 startingPage "111464" @default.
- W3130791339 abstract "Advanced age is one of the important contributing factors for musculoskeletal deterioration. Although the exact mechanism behind this degeneration is unknown, it has been previously established that nutritional signaling plays a vital role in musculoskeletal pathophysiology. Our group established the vital role of the essential amino acid, tryptophan, in aging musculoskeletal health. With advanced age, inflammatory factors activate indoleamine 2,3-dioxygenase (IDO1) and accumulate excessive intermediate tryptophan metabolites such as Kynurenine (KYN). With age, Kynurenine accumulates and suppresses osteogenic differentiation, impairs autophagy, promotes early senescence, and alters cellular bioenergetics of bone marrow stem cells. Recent studies have shown that Kynurenine negatively impacts bone marrow stromal cells (BMSCs) and, consequently, promotes bone loss. Overall, understanding the mechanism behind BMSCs losing their ability for osteogenic differentiation can provide insight into the prevention of osteoporosis and the development of targeted therapies. Therefore, in this article, we review Kynurenine and how it plays a vital role in BMSC dysfunction and bone loss with age." @default.
- W3130791339 created "2021-03-01" @default.
- W3130791339 creator A5014054125 @default.
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- W3130791339 date "2021-04-01" @default.
- W3130791339 modified "2023-10-16" @default.
- W3130791339 title "Kynurenine induces an age-related phenotype in bone marrow stromal cells" @default.
- W3130791339 cites W1076432193 @default.
- W3130791339 cites W1494339596 @default.
- W3130791339 cites W1504356861 @default.
- W3130791339 cites W1541481571 @default.
- W3130791339 cites W1596887205 @default.
- W3130791339 cites W1603640418 @default.
- W3130791339 cites W1606950487 @default.
- W3130791339 cites W1648903440 @default.
- W3130791339 cites W1706247353 @default.
- W3130791339 cites W1840439998 @default.
- W3130791339 cites W1840962824 @default.
- W3130791339 cites W1887681162 @default.
- W3130791339 cites W1911969665 @default.
- W3130791339 cites W1957998012 @default.
- W3130791339 cites W1963788225 @default.
- W3130791339 cites W1965470471 @default.
- W3130791339 cites W1967493255 @default.
- W3130791339 cites W1967647163 @default.
- W3130791339 cites W1969385456 @default.
- W3130791339 cites W1970554352 @default.
- W3130791339 cites W1971400022 @default.
- W3130791339 cites W1972286422 @default.
- W3130791339 cites W1975525956 @default.
- W3130791339 cites W1977381537 @default.
- W3130791339 cites W1977407101 @default.
- W3130791339 cites W1982377655 @default.
- W3130791339 cites W1986960660 @default.
- W3130791339 cites W1987108430 @default.
- W3130791339 cites W1988088217 @default.
- W3130791339 cites W1988201054 @default.
- W3130791339 cites W1991739832 @default.
- W3130791339 cites W1993640536 @default.
- W3130791339 cites W2001347353 @default.
- W3130791339 cites W200155906 @default.
- W3130791339 cites W2006276964 @default.
- W3130791339 cites W2008280391 @default.
- W3130791339 cites W2016547417 @default.
- W3130791339 cites W2020783130 @default.
- W3130791339 cites W2024039167 @default.
- W3130791339 cites W2024205788 @default.
- W3130791339 cites W2025050538 @default.
- W3130791339 cites W2025665129 @default.
- W3130791339 cites W2027069013 @default.
- W3130791339 cites W2027762021 @default.
- W3130791339 cites W2028545958 @default.
- W3130791339 cites W2034000134 @default.
- W3130791339 cites W2034655872 @default.
- W3130791339 cites W2038543378 @default.
- W3130791339 cites W2039607936 @default.
- W3130791339 cites W2039980606 @default.
- W3130791339 cites W2041808790 @default.
- W3130791339 cites W2047730749 @default.
- W3130791339 cites W2049268706 @default.
- W3130791339 cites W2050551830 @default.
- W3130791339 cites W2051922866 @default.
- W3130791339 cites W2056971814 @default.
- W3130791339 cites W2058839233 @default.
- W3130791339 cites W2061819518 @default.
- W3130791339 cites W2062461416 @default.
- W3130791339 cites W2063863569 @default.
- W3130791339 cites W2067162108 @default.
- W3130791339 cites W2075291842 @default.
- W3130791339 cites W2075679933 @default.
- W3130791339 cites W2087408461 @default.
- W3130791339 cites W2096357902 @default.
- W3130791339 cites W2102505450 @default.
- W3130791339 cites W2104908670 @default.
- W3130791339 cites W2111450457 @default.
- W3130791339 cites W2112822581 @default.
- W3130791339 cites W2117415152 @default.
- W3130791339 cites W2117738774 @default.
- W3130791339 cites W2124925707 @default.
- W3130791339 cites W2126525177 @default.
- W3130791339 cites W2129155846 @default.
- W3130791339 cites W2131301672 @default.
- W3130791339 cites W2131341073 @default.
- W3130791339 cites W2137177885 @default.
- W3130791339 cites W2144780308 @default.
- W3130791339 cites W2147112470 @default.
- W3130791339 cites W2150077660 @default.
- W3130791339 cites W2150665743 @default.
- W3130791339 cites W2153101639 @default.
- W3130791339 cites W2155551485 @default.
- W3130791339 cites W2157005154 @default.
- W3130791339 cites W2161715983 @default.