FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130907588> ?p ?o ?g. }

• W3130907588 abstract "CD19-directed chimeric antigen receptors (CAR) T cells induce impressive rates of complete response in advanced B-cell malignancies, specially in B-cell acute lymphoblastic leukemia (B-ALL). However, CAR T-cell-treated patients eventually progress due to poor CAR T-cell persistence and/or disease relapse. The bone marrow (BM) is the primary location for acute leukemia. The rapid/efficient colonization of the BM by systemically infused CD19-CAR T cells might enhance CAR T-cell activity and persistence, thus, offering clinical benefits. Circulating cells traffic to BM upon binding of tetrasaccharide sialyl-Lewis X (sLeX)-decorated E-selectin ligands (sialofucosylated) to the E-selectin receptor expressed in the vascular endothelium. sLeX-installation in E-selectin ligands is achieved through an ex vivo fucosylation reaction. Here, we sought to characterize the basal and cell-autonomous display of sLeX in CAR T-cells activated using different cytokines, and to assess whether exofucosylation of E-selectin ligands improves CD19-CAR T-cell activity and BM homing. We report that cell-autonomous sialofucosylation (sLeX display) steadily increases in culture- and in vivo-expanded CAR T cells, and that, the cytokines used during T-cell activation influence both the degree of such endogenous sialofucosylation and the CD19-CAR T-cell efficacy and persistence in vivo. However, glycoengineered enforced sialofucosylation of E-selectin ligands was dispensable for CD19-CAR T-cell activity and BM homing in multiple xenograft models regardless the cytokines employed for T-cell expansion, thus, representing a dispensable strategy for CD19-CAR T-cell therapy." @default.
• W3130907588 created "2021-03-01" @default.
• W3130907588 creator A5005617864 @default.
• W3130907588 creator A5030726119 @default.
• W3130907588 creator A5038001964 @default.
• W3130907588 creator A5041962132 @default.
• W3130907588 creator A5057080786 @default.
• W3130907588 creator A5061922466 @default.
• W3130907588 creator A5063314713 @default.
• W3130907588 creator A5063848310 @default.
• W3130907588 creator A5076464182 @default.
• W3130907588 creator A5080250204 @default.
• W3130907588 creator A5090429036 @default.
• W3130907588 date "2021-02-01" @default.
• W3130907588 modified "2023-10-17" @default.
• W3130907588 title "Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing" @default.
• W3130907588 cites W1262816711 @default.
• W3130907588 cites W1665862639 @default.
• W3130907588 cites W1755350398 @default.
• W3130907588 cites W1963522404 @default.
• W3130907588 cites W1965570423 @default.
• W3130907588 cites W1973506842 @default.
• W3130907588 cites W1977380831 @default.
• W3130907588 cites W1978333303 @default.
• W3130907588 cites W1987081782 @default.
• W3130907588 cites W1989457547 @default.
• W3130907588 cites W2051549641 @default.
• W3130907588 cites W2055044750 @default.
• W3130907588 cites W2059861322 @default.
• W3130907588 cites W2073268996 @default.
• W3130907588 cites W2090807791 @default.
• W3130907588 cites W2113355655 @default.
• W3130907588 cites W2118796952 @default.
• W3130907588 cites W2130304173 @default.
• W3130907588 cites W2144903567 @default.
• W3130907588 cites W2157603347 @default.
• W3130907588 cites W2288407131 @default.
• W3130907588 cites W2464354826 @default.
• W3130907588 cites W2599210471 @default.
• W3130907588 cites W2605401527 @default.
• W3130907588 cites W2770578347 @default.
• W3130907588 cites W2789257778 @default.
• W3130907588 cites W2792464793 @default.
• W3130907588 cites W2810577801 @default.
• W3130907588 cites W2888063816 @default.
• W3130907588 cites W2904266952 @default.
• W3130907588 cites W2908732267 @default.
• W3130907588 cites W2916598733 @default.
• W3130907588 cites W2917762074 @default.
• W3130907588 cites W2919051790 @default.
• W3130907588 cites W2922471907 @default.
• W3130907588 cites W2944196444 @default.
• W3130907588 cites W2981307368 @default.
• W3130907588 cites W2981453782 @default.
• W3130907588 cites W2991578820 @default.
• W3130907588 cites W3005412445 @default.
• W3130907588 doi "https://doi.org/10.1002/ctm2.280" @default.
• W3130907588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7901721" @default.
• W3130907588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33634970" @default.
• W3130907588 hasPublicationYear "2021" @default.
• W3130907588 type Work @default.
• W3130907588 sameAs 3130907588 @default.
• W3130907588 citedByCount "9" @default.
• W3130907588 countsByYear W31309075882021 @default.
• W3130907588 countsByYear W31309075882022 @default.
• W3130907588 countsByYear W31309075882023 @default.
• W3130907588 crossrefType "journal-article" @default.
• W3130907588 hasAuthorship W3130907588A5005617864 @default.
• W3130907588 hasAuthorship W3130907588A5030726119 @default.
• W3130907588 hasAuthorship W3130907588A5038001964 @default.
• W3130907588 hasAuthorship W3130907588A5041962132 @default.
• W3130907588 hasAuthorship W3130907588A5057080786 @default.
• W3130907588 hasAuthorship W3130907588A5061922466 @default.
• W3130907588 hasAuthorship W3130907588A5063314713 @default.
• W3130907588 hasAuthorship W3130907588A5063848310 @default.
• W3130907588 hasAuthorship W3130907588A5076464182 @default.
• W3130907588 hasAuthorship W3130907588A5080250204 @default.
• W3130907588 hasAuthorship W3130907588A5090429036 @default.
• W3130907588 hasBestOaLocation W31309075881 @default.
• W3130907588 hasConcept C147483822 @default.
• W3130907588 hasConcept C1491633281 @default.
• W3130907588 hasConcept C151872237 @default.
• W3130907588 hasConcept C185592680 @default.
• W3130907588 hasConcept C18903297 @default.
• W3130907588 hasConcept C203014093 @default.
• W3130907588 hasConcept C2776090121 @default.
• W3130907588 hasConcept C2778461978 @default.
• W3130907588 hasConcept C2778957590 @default.
• W3130907588 hasConcept C2780007613 @default.
• W3130907588 hasConcept C3875195 @default.
• W3130907588 hasConcept C502942594 @default.
• W3130907588 hasConcept C55493867 @default.
• W3130907588 hasConcept C86803240 @default.
• W3130907588 hasConcept C8891405 @default.
• W3130907588 hasConcept C95444343 @default.
• W3130907588 hasConceptScore W3130907588C147483822 @default.
• W3130907588 hasConceptScore W3130907588C1491633281 @default.
• W3130907588 hasConceptScore W3130907588C151872237 @default.
• W3130907588 hasConceptScore W3130907588C185592680 @default.
• W3130907588 hasConceptScore W3130907588C18903297 @default.

• next