FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3130966114> ?p ?o ?g. }

• W3130966114 abstract "Ectopic fat deposition (EFD) in the kidney plays a key role in the development of diabetic nephropathy (DN). Mitochondria-associated ER membranes (MAMs) are structures that connect to the endoplasmic reticulum (ER) and are involved in lipid metabolism. However, there are few studies on MAMs in the field of kidney disease, and the relationship between EFD and MAMs in DN is still unclear. In this study, increased EFD in the kidneys of DN patients was observed, and analysis showed that the degree of EFD was positively correlated with renal damage. Then, the MAMs were quantified by an in situ proximity ligation assay (PLA). The MAMs in the kidneys were found to gradually decrease through the different stages of DN, while the expression of ADRP (a marker of lipid droplets) and tubulointerstitial damage increased. Moreover, correlation analysis showed that the MAMs were negatively correlated with serum lipid levels, the EFD in the kidney and renal damage. Finally, we observed decreased expression of MAM-control proteins (DsbA-L, PACS-2, and MFN-2) in different stages of DN and they were associated with lipid deposition and renal damage. These data showed that the destruction of MAMs in DN might be the cause of EFD and interstitial damage in the kidney." @default.
• W3130966114 created "2021-03-01" @default.
• W3130966114 creator A5018462307 @default.
• W3130966114 creator A5020306816 @default.
• W3130966114 creator A5026065861 @default.
• W3130966114 creator A5030494055 @default.
• W3130966114 creator A5039493947 @default.
• W3130966114 creator A5042481434 @default.
• W3130966114 creator A5051754049 @default.
• W3130966114 creator A5052583087 @default.
• W3130966114 creator A5053423526 @default.
• W3130966114 creator A5075647150 @default.
• W3130966114 creator A5081508616 @default.
• W3130966114 creator A5091573005 @default.
• W3130966114 date "2021-02-19" @default.
• W3130966114 modified "2023-10-18" @default.
• W3130966114 title "MAMs Protect Against Ectopic Fat Deposition and Lipid-Related Kidney Damage in DN Patients" @default.
• W3130966114 cites W1907964358 @default.
• W3130966114 cites W1980220077 @default.
• W3130966114 cites W1991328311 @default.
• W3130966114 cites W1991425198 @default.
• W3130966114 cites W2030241337 @default.
• W3130966114 cites W2061631515 @default.
• W3130966114 cites W2076386951 @default.
• W3130966114 cites W2078660473 @default.
• W3130966114 cites W2094077779 @default.
• W3130966114 cites W2130492862 @default.
• W3130966114 cites W2136490577 @default.
• W3130966114 cites W2170638980 @default.
• W3130966114 cites W2210163103 @default.
• W3130966114 cites W2464307806 @default.
• W3130966114 cites W2511562679 @default.
• W3130966114 cites W2582717909 @default.
• W3130966114 cites W2730776610 @default.
• W3130966114 cites W2749235382 @default.
• W3130966114 cites W2753810277 @default.
• W3130966114 cites W2778428592 @default.
• W3130966114 cites W2782144118 @default.
• W3130966114 cites W2783880365 @default.
• W3130966114 cites W2789346990 @default.
• W3130966114 cites W2915212211 @default.
• W3130966114 cites W2932158327 @default.
• W3130966114 cites W2943384428 @default.
• W3130966114 cites W2963142803 @default.
• W3130966114 cites W2971400725 @default.
• W3130966114 cites W2991446723 @default.
• W3130966114 cites W3006245972 @default.
• W3130966114 doi "https://doi.org/10.3389/fendo.2021.609580" @default.
• W3130966114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7933555" @default.
• W3130966114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33679616" @default.
• W3130966114 hasPublicationYear "2021" @default.
• W3130966114 type Work @default.
• W3130966114 sameAs 3130966114 @default.
• W3130966114 citedByCount "13" @default.
• W3130966114 countsByYear W31309661142021 @default.
• W3130966114 countsByYear W31309661142022 @default.
• W3130966114 countsByYear W31309661142023 @default.
• W3130966114 crossrefType "journal-article" @default.
• W3130966114 hasAuthorship W3130966114A5018462307 @default.
• W3130966114 hasAuthorship W3130966114A5020306816 @default.
• W3130966114 hasAuthorship W3130966114A5026065861 @default.
• W3130966114 hasAuthorship W3130966114A5030494055 @default.
• W3130966114 hasAuthorship W3130966114A5039493947 @default.
• W3130966114 hasAuthorship W3130966114A5042481434 @default.
• W3130966114 hasAuthorship W3130966114A5051754049 @default.
• W3130966114 hasAuthorship W3130966114A5052583087 @default.
• W3130966114 hasAuthorship W3130966114A5053423526 @default.
• W3130966114 hasAuthorship W3130966114A5075647150 @default.
• W3130966114 hasAuthorship W3130966114A5081508616 @default.
• W3130966114 hasAuthorship W3130966114A5091573005 @default.
• W3130966114 hasBestOaLocation W31309661141 @default.
• W3130966114 hasConcept C126322002 @default.
• W3130966114 hasConcept C134018914 @default.
• W3130966114 hasConcept C151730666 @default.
• W3130966114 hasConcept C158617107 @default.
• W3130966114 hasConcept C185592680 @default.
• W3130966114 hasConcept C2778653478 @default.
• W3130966114 hasConcept C2779922275 @default.
• W3130966114 hasConcept C2780091579 @default.
• W3130966114 hasConcept C2816523 @default.
• W3130966114 hasConcept C4733338 @default.
• W3130966114 hasConcept C64297162 @default.
• W3130966114 hasConcept C71924100 @default.
• W3130966114 hasConcept C86803240 @default.
• W3130966114 hasConcept C95444343 @default.
• W3130966114 hasConceptScore W3130966114C126322002 @default.
• W3130966114 hasConceptScore W3130966114C134018914 @default.
• W3130966114 hasConceptScore W3130966114C151730666 @default.
• W3130966114 hasConceptScore W3130966114C158617107 @default.
• W3130966114 hasConceptScore W3130966114C185592680 @default.
• W3130966114 hasConceptScore W3130966114C2778653478 @default.
• W3130966114 hasConceptScore W3130966114C2779922275 @default.
• W3130966114 hasConceptScore W3130966114C2780091579 @default.
• W3130966114 hasConceptScore W3130966114C2816523 @default.
• W3130966114 hasConceptScore W3130966114C4733338 @default.
• W3130966114 hasConceptScore W3130966114C64297162 @default.
• W3130966114 hasConceptScore W3130966114C71924100 @default.
• W3130966114 hasConceptScore W3130966114C86803240 @default.
• W3130966114 hasConceptScore W3130966114C95444343 @default.
• W3130966114 hasFunder F4320321001 @default.

• next