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- W3131002994 abstract "For more than 50 years, oral vitamin K antagonists were the choice of anticoagulant for the long-term treatment and prevention of arterial and venous thromboembolic events. In recent years, four direct oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban and edoxaban have been compared with warfarin for thromboembolism prevention. These anticoagulants directly inhibit specific proteins within the coagulation cascade; in contrast, oral vitamin K antagonists inhibit the synthesis of vitamin K-dependent clotting factors. Dabigatran, a direct thrombin inhibitor, and rivaroxaban, apixaban and edoxaban, the factor Xa inhibitors, produce a more predictable, less labile anticoagulant effect. DOACs do not have limitations inherent vitamin K antagonists. DOACs have a predictable pharmacokinetic profile and are free of advers drugs reactions inherent in vitamin K antagonists. However, it is necessary to take into account the pharmacogenetic characteristics of the individual that can affect effectiveness and safety of use of DOACs. The results carried out to the present fundamental and clinical studies of DOACs studies demonstrate an undeniable the influence of genome changes on the pharmacokinetics and pharmacodynamics of DOACs. However, the studies need to be continued. There is a need to plan and conduct larger studies in various ethnic groups with the inclusion of sufficient associative genetic studies of the number of patients in each of the documented groups treatments with well-defined phenotypes." @default.
- W3131002994 created "2021-03-01" @default.
- W3131002994 creator A5004487173 @default.
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- W3131002994 date "2021-11-24" @default.
- W3131002994 modified "2023-10-14" @default.
- W3131002994 title "Pharmacogenetics of Direct Oral Anticoagulants" @default.
- W3131002994 cites W1507763452 @default.
- W3131002994 cites W1508157224 @default.
- W3131002994 cites W1559665756 @default.
- W3131002994 cites W1564607482 @default.
- W3131002994 cites W1568662837 @default.
- W3131002994 cites W1581073652 @default.
- W3131002994 cites W1847143642 @default.
- W3131002994 cites W1964486705 @default.
- W3131002994 cites W1979275346 @default.
- W3131002994 cites W1993406555 @default.
- W3131002994 cites W1993906283 @default.
- W3131002994 cites W2008955498 @default.
- W3131002994 cites W2010436911 @default.
- W3131002994 cites W2014822095 @default.
- W3131002994 cites W2021621876 @default.
- W3131002994 cites W2026517280 @default.
- W3131002994 cites W2027735039 @default.
- W3131002994 cites W2028162842 @default.
- W3131002994 cites W2031698432 @default.
- W3131002994 cites W2039359392 @default.
- W3131002994 cites W2039691125 @default.
- W3131002994 cites W2043822514 @default.
- W3131002994 cites W2045987573 @default.
- W3131002994 cites W2053780698 @default.
- W3131002994 cites W2055619480 @default.
- W3131002994 cites W2060580339 @default.
- W3131002994 cites W2062946016 @default.
- W3131002994 cites W2067747440 @default.
- W3131002994 cites W2071504629 @default.
- W3131002994 cites W2075433538 @default.
- W3131002994 cites W2077197798 @default.
- W3131002994 cites W2078568237 @default.
- W3131002994 cites W2083600673 @default.
- W3131002994 cites W2096592200 @default.
- W3131002994 cites W2105258086 @default.
- W3131002994 cites W2107205214 @default.
- W3131002994 cites W2115273341 @default.
- W3131002994 cites W2116005824 @default.
- W3131002994 cites W2118092611 @default.
- W3131002994 cites W2121703474 @default.
- W3131002994 cites W2122667952 @default.
- W3131002994 cites W2124693396 @default.
- W3131002994 cites W2124882231 @default.
- W3131002994 cites W2127897756 @default.
- W3131002994 cites W2128869290 @default.
- W3131002994 cites W2130909191 @default.
- W3131002994 cites W2133088218 @default.
- W3131002994 cites W2134819485 @default.
- W3131002994 cites W2135230339 @default.
- W3131002994 cites W2147930289 @default.
- W3131002994 cites W2151514200 @default.
- W3131002994 cites W2155373527 @default.
- W3131002994 cites W2158902152 @default.
- W3131002994 cites W2159677620 @default.
- W3131002994 cites W2162965136 @default.
- W3131002994 cites W2166672545 @default.
- W3131002994 cites W2167182965 @default.
- W3131002994 cites W2168571366 @default.
- W3131002994 cites W2174049160 @default.
- W3131002994 cites W2237496421 @default.
- W3131002994 cites W2263934434 @default.
- W3131002994 cites W2300230658 @default.
- W3131002994 cites W2340468754 @default.
- W3131002994 cites W2399437025 @default.
- W3131002994 cites W2435343268 @default.
- W3131002994 cites W2509632682 @default.
- W3131002994 cites W2518583188 @default.
- W3131002994 cites W2557302462 @default.
- W3131002994 cites W2559528249 @default.
- W3131002994 cites W2621404381 @default.
- W3131002994 cites W2730172418 @default.
- W3131002994 cites W2732998799 @default.
- W3131002994 cites W2762004580 @default.
- W3131002994 cites W2782547839 @default.
- W3131002994 cites W2791056163 @default.
- W3131002994 cites W2791399109 @default.
- W3131002994 cites W2792127250 @default.
- W3131002994 cites W2794030701 @default.
- W3131002994 cites W2815023697 @default.
- W3131002994 cites W2884379119 @default.
- W3131002994 cites W2896426515 @default.
- W3131002994 cites W2905196766 @default.
- W3131002994 cites W2909073103 @default.
- W3131002994 cites W2917027556 @default.
- W3131002994 cites W2925297114 @default.
- W3131002994 cites W2933821748 @default.
- W3131002994 cites W2972317421 @default.
- W3131002994 cites W2981083600 @default.