Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131007036> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3131007036 endingPage "131" @default.
- W3131007036 startingPage "119" @default.
- W3131007036 abstract "Tinospora cordifolia is an important ayurvedic herb known for its immune stimulating effect. In this investigation, we describe the galectin-3 inhibitory and immune stimulating properties of a novel water-soluble nutraceutical made from Tinospora cordifolia stem. This proprietary extract (T2CA) had a total yield of 6% and contained 86.9% carbohydrates with a high proportion of patented (1,4)-α-D-glucan in it. The T2CA activated T-cytotoxic and NK cells significantly contributing to its immune stimulating effect. Moreover, T2CA induced the activation of functional NK cells in human lymphocyte cultures that in turn contributed to the death of K562 leukemic cells in a dose-dependent manner in co-culture experiments. T2CA inhibited the expression of phosphorylated galectin-3 expression in human glioblastoma cell line which in turn inhibits the activity of MMP2 and MMP9 proteins in zymography investigations and inhibits migration of cancer cells in in vitro scratch assay. Western blot hybridization studies showed that T2CA downregulates the expression of total gal 3 proteins and extended the survival of AKR/J mice injected with Ehrlich ascites tumor cells in the Kepler-Meier survival curve analysis. The inhibitory effect of T2CA on phopho-galectin-3 expression and the activation of T-cytotoxic and NK cells suggested its protective effects against pathogenic infections and human malignancies via its immune stimulating mechanisms." @default.
- W3131007036 created "2021-03-01" @default.
- W3131007036 creator A5031745684 @default.
- W3131007036 creator A5055480352 @default.
- W3131007036 creator A5066064009 @default.
- W3131007036 creator A5070502419 @default.
- W3131007036 date "2021-01-17" @default.
- W3131007036 modified "2023-09-23" @default.
- W3131007036 title "Immune stimulating and galectin-3 inhibitory effects of a hydrophilic polysaccharide nutraceutical from Tinospora cordifolia" @default.
- W3131007036 doi "https://doi.org/10.5138/09750185.2449" @default.
- W3131007036 hasPublicationYear "2021" @default.
- W3131007036 type Work @default.
- W3131007036 sameAs 3131007036 @default.
- W3131007036 citedByCount "0" @default.
- W3131007036 crossrefType "journal-article" @default.
- W3131007036 hasAuthorship W3131007036A5031745684 @default.
- W3131007036 hasAuthorship W3131007036A5055480352 @default.
- W3131007036 hasAuthorship W3131007036A5066064009 @default.
- W3131007036 hasAuthorship W3131007036A5070502419 @default.
- W3131007036 hasConcept C153911025 @default.
- W3131007036 hasConcept C154317977 @default.
- W3131007036 hasConcept C185592680 @default.
- W3131007036 hasConcept C202751555 @default.
- W3131007036 hasConcept C203014093 @default.
- W3131007036 hasConcept C2778523797 @default.
- W3131007036 hasConcept C55493867 @default.
- W3131007036 hasConcept C59822182 @default.
- W3131007036 hasConcept C86803240 @default.
- W3131007036 hasConcept C8891405 @default.
- W3131007036 hasConcept C98274493 @default.
- W3131007036 hasConceptScore W3131007036C153911025 @default.
- W3131007036 hasConceptScore W3131007036C154317977 @default.
- W3131007036 hasConceptScore W3131007036C185592680 @default.
- W3131007036 hasConceptScore W3131007036C202751555 @default.
- W3131007036 hasConceptScore W3131007036C203014093 @default.
- W3131007036 hasConceptScore W3131007036C2778523797 @default.
- W3131007036 hasConceptScore W3131007036C55493867 @default.
- W3131007036 hasConceptScore W3131007036C59822182 @default.
- W3131007036 hasConceptScore W3131007036C86803240 @default.
- W3131007036 hasConceptScore W3131007036C8891405 @default.
- W3131007036 hasConceptScore W3131007036C98274493 @default.
- W3131007036 hasIssue "4" @default.
- W3131007036 hasLocation W31310070361 @default.
- W3131007036 hasOpenAccess W3131007036 @default.
- W3131007036 hasPrimaryLocation W31310070361 @default.
- W3131007036 hasRelatedWork W1968161181 @default.
- W3131007036 hasRelatedWork W1979545488 @default.
- W3131007036 hasRelatedWork W2013874906 @default.
- W3131007036 hasRelatedWork W2017919104 @default.
- W3131007036 hasRelatedWork W2020552300 @default.
- W3131007036 hasRelatedWork W2030891765 @default.
- W3131007036 hasRelatedWork W2032210657 @default.
- W3131007036 hasRelatedWork W2052327655 @default.
- W3131007036 hasRelatedWork W2054892603 @default.
- W3131007036 hasRelatedWork W2055962749 @default.
- W3131007036 hasRelatedWork W2057594340 @default.
- W3131007036 hasRelatedWork W2294347997 @default.
- W3131007036 hasRelatedWork W2319240824 @default.
- W3131007036 hasRelatedWork W2591709031 @default.
- W3131007036 hasRelatedWork W2781558823 @default.
- W3131007036 hasRelatedWork W2966639700 @default.
- W3131007036 hasRelatedWork W2975476256 @default.
- W3131007036 hasRelatedWork W3012959286 @default.
- W3131007036 hasRelatedWork W3103899649 @default.
- W3131007036 hasRelatedWork W3120771591 @default.
- W3131007036 hasVolume "12" @default.
- W3131007036 isParatext "false" @default.
- W3131007036 isRetracted "false" @default.
- W3131007036 magId "3131007036" @default.
- W3131007036 workType "article" @default.