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• W3131072156 endingPage "100815" @default.
• W3131072156 startingPage "100815" @default.
• W3131072156 abstract "Environmental salinity not only affects the physiological processes such as osmoregulation and hormonal control, but also changes the immune system in fishes. Studies are limited in fish on the roles of the T cell receptor (TCR)-related genes in relation to changes in environmental salinity. A large group of salinity-challenged transcripts was obtained in gills of marbled eel (Anguilla marmorata). Moreover, bioinformatic ways were used to identify the enriched TCR pathway related genes which were significantly different expressed in fresh water (FW), brackish water (BW) and seawater (SW). Meanwhile, the RT-qPCR results were validated and consistent with the RNA-seq results. TCR a, TCR b, CD45, CD28, PI3K, LCK and LAT were up-regulated when the salinity increases in BW and SW, which connected with the related signaling pathways (Ras-MAPK and PKC pathway). CD4 and Zap70 were down-regulated when the salinity increases in BW and SW, which connected with the PLC pathway. The research offers a novel viewpoint to explore the immune pathways including the TCR pathway in fish based on transcriptome." @default.
• W3131072156 created "2021-03-01" @default.
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• W3131072156 date "2021-06-01" @default.
• W3131072156 modified "2023-10-15" @default.
• W3131072156 title "Environmental salinity influences the branchial expression of TCR pathway related genes based on transcriptome of a catadromous fish" @default.
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• W3131072156 doi "https://doi.org/10.1016/j.cbd.2021.100815" @default.
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