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- W3131074216 abstract "Abstract Recently, it was found that proteomes from poliovirus, measles virus, dengue virus, and severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) have high molecular mimicry at the heptapeptide level with the human proteome, while heptapeptide commonality is minimal or absent with proteomes from nonhuman primates, that is, gorilla, chimpanzee, and rhesus macaque. To acquire more data on the issue, analyses here have been expanded to Ebola virus, Francisella tularensis, human immunodeficiency virus-1 (HIV-1), Toxoplasma gondii, Variola virus, and Yersinia pestis. Results confirm that heptapeptide overlap is high between pathogens and Homo sapiens, but not between pathogens and primates. Data are discussed in light of the possible genetic bases that differently model primate phenomes, thus possibly underlying the zero/low level of molecular mimicry between infectious agents and primates. Notably, this study might help address preclinical vaccine tests that currently utilize primates as animal models, since autoimmune cross-reactions and the consequent adverse events cannot occur in absentia of shared sequences." @default.
- W3131074216 created "2021-03-01" @default.
- W3131074216 creator A5040099455 @default.
- W3131074216 date "2021-02-19" @default.
- W3131074216 modified "2023-10-16" @default.
- W3131074216 title "Lack of Molecular Mimicry between Nonhuman Primates and Infectious Pathogens: The Possible Genetic Bases" @default.
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- W3131074216 doi "https://doi.org/10.1055/s-0041-1724106" @default.
- W3131074216 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7964256" @default.
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- W3131074216 hasPublicationYear "2021" @default.
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