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- W3131136917 abstract "Abstract Orexins are hypothalamic neuropeptides originally discovered to play a role in the regulation of feeding behaviour. The broad connections of orexin neurons to mesocorticolimbic circuitry suggest they may play a role in mediating reward‐related behaviour beyond homeostatic feeding. Here, we review the role of orexin in a variety of eating‐related behaviour, with a focus on reward and motivation, and the neural circuits driving these effects. One emerging finding is the involvement of orexins in hedonic and appetitive behaviour towards palatable food, in addition to their role in homeostatic feeding. This review discusses the brain circuitry and possible mechanisms underlying the role of orexins in these behaviours. Overall, there is a marked bias in the literature towards studies involving male subjects. As such, future work needs to be done to involve female subjects. In summary, orexins play an important role in driving motivation for high salient rewards such as highly palatable food and may serve as the intersection between homeostatic and hedonic feeding. image" @default.
- W3131136917 created "2021-03-01" @default.
- W3131136917 creator A5010164777 @default.
- W3131136917 creator A5010682036 @default.
- W3131136917 creator A5057243298 @default.
- W3131136917 creator A5091320259 @default.
- W3131136917 date "2021-03-10" @default.
- W3131136917 modified "2023-10-17" @default.
- W3131136917 title "Orexins (hypocretins): The intersection between homeostatic and hedonic feeding" @default.
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