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• W3131175737 abstract "The extent of cellular heterogeneity involved in neuronal regeneration after spinal cord injury (SCI) remains unclear. Therefore, we established stress-responsive transgenic zebrafish embryos with SCI. As a result, we found an SCI-induced cell population, termed SCI stress-responsive regenerating cells (SrRCs), essential for neuronal regeneration post-SCI. SrRCs were mostly composed of subtypes of radial glia (RGs-SrRCs) and neuron stem/progenitor cells (NSPCs-SrRCs) that are able to differentiate into neurons, and they formed a bridge across the lesion and connected with neighbouring undamaged motor neurons post-SCI. Compared to SrRCs at the caudal side of the SCI site (caudal-SrRCs), rostral-SrRCs participated more actively in neuronal regeneration. After RNA-seq analysis, we discovered that caveolin 1 ( cav1 ) was significantly upregulated in rostral-SrRCs and that cav1 was responsible for the axonal regrowth and regenerative capability of rostral-SrRCs. Collectively, we define a specific SCI-induced cell population, SrRCs, involved in neuronal regeneration, demonstrate that rostral-SrRCs exhibit higher neuronal differentiation capability and prove that cav1 is predominantly expressed in rostral-SrRCs, playing a major role in neuronal regeneration after SCI." @default.
• W3131175737 created "2021-03-01" @default.
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• W3131175737 date "2021-02-01" @default.
• W3131175737 modified "2023-10-16" @default.
• W3131175737 title "Injury-induced Cavl-expressing cells at lesion rostral side play major roles in spinal cord regeneration" @default.
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• W3131175737 doi "https://doi.org/10.1098/rsob.200304" @default.
• W3131175737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8061693" @default.
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