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- W3131176903 endingPage "4880" @default.
- W3131176903 startingPage "4850" @default.
- W3131176903 abstract "Aging is a physiological process whose underlying mechanisms are still largely unknown. The study of the biochemical transformations associated with aging is crucial for understanding this process and could translate into an improvement of the quality of life of the aging population. Red blood cells (RBCs) are the most abundant cells in humans and are involved in essential functions that could undergo different alterations with age. The present study analyzed the metabolic alterations experienced by RBCs during aging, as well as the influence of obesity and gender in this process. To this end, the metabolic profile of 83 samples from healthy and obese patients was obtained by Nuclear Magnetic Resonance spectroscopy. Multivariate statistical analysis revealed differences between Age-1 (≤45) and Age-2 (>45) subgroups, as well as between BMI-1 (<30) and BMI-2 (≥30) subgroups, while no differences were associated with gender. A general decrease in the levels of amino acids was detected with age, in addition to metabolic alterations of glycolysis, the pentose phosphate pathway, nucleotide metabolism, glutathione metabolism and the Luebering-Rapoport shunt. Obesity also had an impact on the metabolomics profile of RBCs; sometimes mimicking the alterations induced by aging, while, in other cases, its influence was the opposite, suggesting these changes could counteract the adaptation of the organism to senescence." @default.
- W3131176903 created "2021-03-01" @default.
- W3131176903 creator A5017014718 @default.
- W3131176903 creator A5018275091 @default.
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- W3131176903 creator A5072466241 @default.
- W3131176903 creator A5076585215 @default.
- W3131176903 creator A5087812090 @default.
- W3131176903 date "2021-02-19" @default.
- W3131176903 modified "2023-10-18" @default.
- W3131176903 title "Metabolic footprint of aging and obesity in red blood cells" @default.
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