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• W3131180680 endingPage "459" @default.
• W3131180680 startingPage "459" @default.
• W3131180680 abstract "Female infertility is mainly caused by ovulation disorders, which affect female reproduction and pregnancy worldwide, with polycystic ovary syndrome (PCOS) being the most prevalent of these. PCOS is a frequent endocrine disease that is associated with abnormal function of the female sex hormone estrogen and estrogen receptors (ERs). Estrogens mediate genomic effects through ERα and ERβ in target tissues. The G-protein-coupled estrogen receptor (GPER) has recently been described as mediating the non-genomic signaling of estrogen. Changes in estrogen receptor signaling pathways affect cellular activities, such as ovulation; cell cycle phase; and cell proliferation, migration, and invasion. Over the years, some selective estrogen receptor modulators (SERMs) have made substantial strides in clinical applications for subfertility with PCOS, such as tamoxifen and clomiphene, however the role of ER in PCOS still needs to be understood. This article focuses on the recent progress in PCOS caused by the abnormal expression of estrogen and ERs in the ovaries and uterus, and the clinical application of related targeted small-molecule drugs." @default.
• W3131180680 created "2021-03-01" @default.
• W3131180680 creator A5056774545 @default.
• W3131180680 creator A5064894078 @default.
• W3131180680 creator A5070565063 @default.
• W3131180680 creator A5079527316 @default.
• W3131180680 date "2021-02-21" @default.
• W3131180680 modified "2023-10-10" @default.
• W3131180680 title "Estrogen Receptors in Polycystic Ovary Syndrome" @default.
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