Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131181639> ?p ?o ?g. }
- W3131181639 endingPage "109024" @default.
- W3131181639 startingPage "109024" @default.
- W3131181639 abstract "Lead (Pb) pollution poses great threats to mammals including human and it is also hazardous to bird life. In this study, RNA sequencing analysis was employed to examine the molecular responses to lead exposure in the liver of a toxicological model species Japanese quails (Coturnix japonica). Female birds were exposed to 0, 50, 500 and 1000 ppm waterborne Pb for 49 days. The results showed that hepatic microstructure was damaged under lead exposure featured by sinusoids dilation and irregularity as well as cell necrosis. Moreover, ultrastructural injury in the liver including mitochondrial swelling and vacuolization as well as nuclear deformation was induced by lead exposure. Lead exposure also caused the decrease of lipid droplets in the liver by oil red O staining. In addition, liver transcriptomic analysis revealed that molecular signaling and functional pathways were disrupted by lead exposure. Meanwhile, the expression of genes involved with hepatic glycerophospholipids metabolism of triglyceride synthesis and lipid transport of triglyceride transfer was significantly down-regulated by lead exposure. Moreover, the up-regulation of genes associated with fatty acid oxidation and the down-regulation of genes related with fatty acid synthesis were caused by lead exposure. The present study implied that lead induced liver malfunction and bird health risks through histopathological damages, molecular signaling disruption, genetic expression alteration and triglyceride metabolism disturbance." @default.
- W3131181639 created "2021-03-01" @default.
- W3131181639 creator A5023395031 @default.
- W3131181639 creator A5025721903 @default.
- W3131181639 creator A5027937292 @default.
- W3131181639 creator A5050487837 @default.
- W3131181639 date "2021-06-01" @default.
- W3131181639 modified "2023-09-22" @default.
- W3131181639 title "Transcriptomic analysis of lead-induced hepatoxicology in female Japanese quails (Coturnix japonica): Implications of triglyceride synthesis, degradation and transport disruption" @default.
- W3131181639 cites W1965506486 @default.
- W3131181639 cites W1981509058 @default.
- W3131181639 cites W1999507242 @default.
- W3131181639 cites W2002573790 @default.
- W3131181639 cites W2016182269 @default.
- W3131181639 cites W2026910132 @default.
- W3131181639 cites W2068437280 @default.
- W3131181639 cites W2071339499 @default.
- W3131181639 cites W2074417939 @default.
- W3131181639 cites W2074768814 @default.
- W3131181639 cites W2077689869 @default.
- W3131181639 cites W2085047795 @default.
- W3131181639 cites W2095570321 @default.
- W3131181639 cites W2100305481 @default.
- W3131181639 cites W2101529316 @default.
- W3131181639 cites W2107277218 @default.
- W3131181639 cites W2147656718 @default.
- W3131181639 cites W2151311812 @default.
- W3131181639 cites W2151699770 @default.
- W3131181639 cites W2153909256 @default.
- W3131181639 cites W2178343589 @default.
- W3131181639 cites W2419063662 @default.
- W3131181639 cites W244609535 @default.
- W3131181639 cites W2541855732 @default.
- W3131181639 cites W2573173004 @default.
- W3131181639 cites W2601241995 @default.
- W3131181639 cites W2615491300 @default.
- W3131181639 cites W2781659199 @default.
- W3131181639 cites W2783676315 @default.
- W3131181639 cites W2791071585 @default.
- W3131181639 cites W2791611068 @default.
- W3131181639 cites W2888503894 @default.
- W3131181639 cites W2898422747 @default.
- W3131181639 cites W2900273130 @default.
- W3131181639 cites W2907865394 @default.
- W3131181639 cites W2909599995 @default.
- W3131181639 cites W2921003104 @default.
- W3131181639 cites W2969343803 @default.
- W3131181639 cites W2971784834 @default.
- W3131181639 cites W2979378950 @default.
- W3131181639 cites W2995072359 @default.
- W3131181639 cites W3042313681 @default.
- W3131181639 cites W3087119948 @default.
- W3131181639 doi "https://doi.org/10.1016/j.cbpc.2021.109024" @default.
- W3131181639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33631343" @default.
- W3131181639 hasPublicationYear "2021" @default.
- W3131181639 type Work @default.
- W3131181639 sameAs 3131181639 @default.
- W3131181639 citedByCount "6" @default.
- W3131181639 countsByYear W31311816392021 @default.
- W3131181639 countsByYear W31311816392022 @default.
- W3131181639 countsByYear W31311816392023 @default.
- W3131181639 crossrefType "journal-article" @default.
- W3131181639 hasAuthorship W3131181639A5023395031 @default.
- W3131181639 hasAuthorship W3131181639A5025721903 @default.
- W3131181639 hasAuthorship W3131181639A5027937292 @default.
- W3131181639 hasAuthorship W3131181639A5050487837 @default.
- W3131181639 hasConcept C104317684 @default.
- W3131181639 hasConcept C126322002 @default.
- W3131181639 hasConcept C134018914 @default.
- W3131181639 hasConcept C150194340 @default.
- W3131181639 hasConcept C162317418 @default.
- W3131181639 hasConcept C25095133 @default.
- W3131181639 hasConcept C2776637226 @default.
- W3131181639 hasConcept C2778163477 @default.
- W3131181639 hasConcept C2778772119 @default.
- W3131181639 hasConcept C2778913445 @default.
- W3131181639 hasConcept C2779134260 @default.
- W3131181639 hasConcept C4733338 @default.
- W3131181639 hasConcept C55493867 @default.
- W3131181639 hasConcept C71924100 @default.
- W3131181639 hasConcept C86803240 @default.
- W3131181639 hasConceptScore W3131181639C104317684 @default.
- W3131181639 hasConceptScore W3131181639C126322002 @default.
- W3131181639 hasConceptScore W3131181639C134018914 @default.
- W3131181639 hasConceptScore W3131181639C150194340 @default.
- W3131181639 hasConceptScore W3131181639C162317418 @default.
- W3131181639 hasConceptScore W3131181639C25095133 @default.
- W3131181639 hasConceptScore W3131181639C2776637226 @default.
- W3131181639 hasConceptScore W3131181639C2778163477 @default.
- W3131181639 hasConceptScore W3131181639C2778772119 @default.
- W3131181639 hasConceptScore W3131181639C2778913445 @default.
- W3131181639 hasConceptScore W3131181639C2779134260 @default.
- W3131181639 hasConceptScore W3131181639C4733338 @default.
- W3131181639 hasConceptScore W3131181639C55493867 @default.
- W3131181639 hasConceptScore W3131181639C71924100 @default.
- W3131181639 hasConceptScore W3131181639C86803240 @default.
- W3131181639 hasFunder F4320321001 @default.
- W3131181639 hasLocation W31311816391 @default.