FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131228145> ?p ?o ?g. }

• W3131228145 endingPage "222" @default.
• W3131228145 startingPage "209" @default.
• W3131228145 abstract "Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation 1 gene (FMR1), a gene that — when epigenetically inactivated by a triplet nucleotide repeat expansion — causes the neurodevelopmental disorder fragile X syndrome (FXS). FMRP is a widely expressed RNA-binding protein with activity that is essential for proper synaptic plasticity and architecture, aspects of neural function that are known to go awry in FXS. Although the neurophysiology of FXS has been described in remarkable detail, research focusing on the molecular biology of FMRP has only scratched the surface. For more than two decades, FMRP has been well established as a translational repressor; however, recent whole transcriptome and translatome analyses in mouse and human models of FXS have shown that FMRP is involved in the regulation of nearly all aspects of gene expression. The emerging mechanistic details of the mechanisms by which FMRP regulates gene expression may offer ways to design new therapies for FXS. Inactivation of the gene encoding fragile X mental retardation protein (FMRP) drives the impairments in brain development and function that underlie fragile X syndrome. Richter and Zhao illustrate how innovative genetic and molecular biology tools have enhanced our understanding of both FMRP’s function and the causes of fragile X syndrome pathophysiology." @default.
• W3131228145 created "2021-03-01" @default.
• W3131228145 creator A5042061460 @default.
• W3131228145 creator A5053691210 @default.
• W3131228145 date "2021-02-19" @default.
• W3131228145 modified "2023-10-12" @default.
• W3131228145 title "The molecular biology of FMRP: new insights into fragile X syndrome" @default.
• W3131228145 cites W1558287800 @default.
• W3131228145 cites W1844634253 @default.
• W3131228145 cites W1955207250 @default.
• W3131228145 cites W1972885462 @default.
• W3131228145 cites W1981638948 @default.
• W3131228145 cites W1991587102 @default.
• W3131228145 cites W2002780348 @default.
• W3131228145 cites W2004342279 @default.
• W3131228145 cites W2004575367 @default.
• W3131228145 cites W2006602581 @default.
• W3131228145 cites W2022976940 @default.
• W3131228145 cites W2026456570 @default.
• W3131228145 cites W2036338927 @default.
• W3131228145 cites W2036879857 @default.
• W3131228145 cites W2048108096 @default.
• W3131228145 cites W2052326665 @default.
• W3131228145 cites W2056013470 @default.
• W3131228145 cites W2063147267 @default.
• W3131228145 cites W2065476928 @default.
• W3131228145 cites W2067565730 @default.
• W3131228145 cites W2068065584 @default.
• W3131228145 cites W2068843656 @default.
• W3131228145 cites W2071013424 @default.
• W3131228145 cites W2075344525 @default.
• W3131228145 cites W2079517684 @default.
• W3131228145 cites W2084889756 @default.
• W3131228145 cites W2089927164 @default.
• W3131228145 cites W2091796431 @default.
• W3131228145 cites W2098756736 @default.
• W3131228145 cites W2099545905 @default.
• W3131228145 cites W2100232590 @default.
• W3131228145 cites W2101635884 @default.
• W3131228145 cites W2106239245 @default.
• W3131228145 cites W2107880079 @default.
• W3131228145 cites W21098528 @default.
• W3131228145 cites W2110811750 @default.
• W3131228145 cites W2116174991 @default.
• W3131228145 cites W2116400924 @default.
• W3131228145 cites W2116996762 @default.
• W3131228145 cites W2117038257 @default.
• W3131228145 cites W2118015973 @default.
• W3131228145 cites W2118122718 @default.
• W3131228145 cites W2120211068 @default.
• W3131228145 cites W2122684341 @default.
• W3131228145 cites W2124495107 @default.
• W3131228145 cites W2124859239 @default.
• W3131228145 cites W2126621754 @default.
• W3131228145 cites W2134063049 @default.
• W3131228145 cites W2134581110 @default.
• W3131228145 cites W2140752483 @default.
• W3131228145 cites W2144995800 @default.
• W3131228145 cites W2145103394 @default.
• W3131228145 cites W2148816697 @default.
• W3131228145 cites W2149919973 @default.
• W3131228145 cites W2150626351 @default.
• W3131228145 cites W2151285111 @default.
• W3131228145 cites W2160371877 @default.
• W3131228145 cites W2175771810 @default.
• W3131228145 cites W2191896591 @default.
• W3131228145 cites W2237226910 @default.
• W3131228145 cites W2294303633 @default.
• W3131228145 cites W2316850457 @default.
• W3131228145 cites W2329426942 @default.
• W3131228145 cites W2345057418 @default.
• W3131228145 cites W2418051327 @default.
• W3131228145 cites W244765127 @default.
• W3131228145 cites W2460957862 @default.
• W3131228145 cites W2522261353 @default.
• W3131228145 cites W2524992411 @default.
• W3131228145 cites W2546967042 @default.
• W3131228145 cites W2565463867 @default.
• W3131228145 cites W2587758306 @default.
• W3131228145 cites W2608560932 @default.
• W3131228145 cites W2610363742 @default.
• W3131228145 cites W2620588197 @default.
• W3131228145 cites W2735720719 @default.
• W3131228145 cites W2744596343 @default.
• W3131228145 cites W2745668358 @default.
• W3131228145 cites W2752985760 @default.
• W3131228145 cites W2759433538 @default.
• W3131228145 cites W2762506271 @default.
• W3131228145 cites W2762868004 @default.
• W3131228145 cites W2766602515 @default.
• W3131228145 cites W2772067948 @default.
• W3131228145 cites W2783970096 @default.
• W3131228145 cites W2797218669 @default.
• W3131228145 cites W2808831647 @default.
• W3131228145 cites W2885103884 @default.
• W3131228145 cites W2885321095 @default.
• W3131228145 cites W2898096243 @default.
• W3131228145 cites W2898814165 @default.

• next