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• W3131250131 abstract "Aim: The development and optimization of Ketorolac tromethamine-loaded polylactic-co-glycolic acid nanoparticles (KT-NPs) for the treatment of inflammatory processes of the eye. Materials & methods: KT-NPs were developed by factorial design and characterized by assessing their physicochemical properties. Biopharmaceutical behavior studies, ocular tolerance, anti-inflammatory efficacy and bioavailability tests were performed on pigs. Results: Optimized KT-NPs of 112 nm, narrow distribution with encapsulation efficiency near 100% were obtained. KT release followed the Weibull model and there was significantly greater retention in the cornea and sclera than in the commercial reference. KT-NPs showed no signs of ocular irritancy and similar anti-inflammatory efficacy to the commercial reference. Conclusion: KT-NPs were a suitable alternative for the treatment of inflammatory disorders of the anterior and posterior segments of the eye as an alternative to conventional topical formulations." @default.
• W3131250131 created "2021-03-01" @default.
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• W3131250131 date "2021-02-01" @default.
• W3131250131 modified "2023-10-18" @default.
• W3131250131 title "Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders" @default.
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• W3131250131 doi "https://doi.org/10.2217/nnm-2020-0403" @default.
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