Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131279730> ?p ?o ?g. }
- W3131279730 abstract "In clear cell renal cell carcinoma, 80% of cases have biallelic inactivation of the VHL gene, leading to constitutive activation of both HIF1α and HIF2α. As HIF2α is the driver of the disease promoting tumour growth and metastasis, drugs targeting HIF2α have been developed. However, resistance is common, therefore new therapies are needed.We assessed the effect of the HIF2α antagonist PT2385 in several steps of tumour development and performed RNAseq to identify genes differentially expressed upon treatment. A drug screening was used to identify drugs with antiproliferative effects on VHL-mutated HIF2α-expressing cells and could increase effectiveness of PT2385.PT2385 did not reduce cell proliferation or clonogenicity but, in contrast to the genetic silencing of HIF2α, it reduced in vitro cell invasion. Many HIF-inducible genes were down-regulated upon PT2385 treatment, whereas some genes involved in cell migration or extracellular matrix were up-regulated. HIF2α was associated with resistance to statins, addition to PT2385 did not increase the sensitivity.this study shows key differences between inhibiting a target versus knockdown, which are potentially targetable." @default.
- W3131279730 created "2021-03-01" @default.
- W3131279730 creator A5005759601 @default.
- W3131279730 creator A5006207516 @default.
- W3131279730 creator A5023518824 @default.
- W3131279730 creator A5028243133 @default.
- W3131279730 creator A5037492199 @default.
- W3131279730 creator A5079331096 @default.
- W3131279730 creator A5079633934 @default.
- W3131279730 creator A5091138255 @default.
- W3131279730 date "2021-08-05" @default.
- W3131279730 modified "2023-10-16" @default.
- W3131279730 title "Differential effects of HIF2α antagonist and HIF2α silencing in renal cancer and sensitivity to repurposed drugs" @default.
- W3131279730 cites W1976980661 @default.
- W3131279730 cites W1989040551 @default.
- W3131279730 cites W1990607537 @default.
- W3131279730 cites W2016626122 @default.
- W3131279730 cites W2020344223 @default.
- W3131279730 cites W2030869361 @default.
- W3131279730 cites W2058141882 @default.
- W3131279730 cites W2060525294 @default.
- W3131279730 cites W2061978660 @default.
- W3131279730 cites W2065739714 @default.
- W3131279730 cites W2073890207 @default.
- W3131279730 cites W2075054245 @default.
- W3131279730 cites W2079075723 @default.
- W3131279730 cites W2086553719 @default.
- W3131279730 cites W2092941122 @default.
- W3131279730 cites W2095882387 @default.
- W3131279730 cites W2113672655 @default.
- W3131279730 cites W2126797928 @default.
- W3131279730 cites W2164210517 @default.
- W3131279730 cites W2167845320 @default.
- W3131279730 cites W2177463952 @default.
- W3131279730 cites W2323751645 @default.
- W3131279730 cites W2329914681 @default.
- W3131279730 cites W2510079645 @default.
- W3131279730 cites W2513249090 @default.
- W3131279730 cites W2514212469 @default.
- W3131279730 cites W2557303080 @default.
- W3131279730 cites W2560629138 @default.
- W3131279730 cites W2612646577 @default.
- W3131279730 cites W2613084028 @default.
- W3131279730 cites W2778771081 @default.
- W3131279730 cites W2799374795 @default.
- W3131279730 cites W2806941617 @default.
- W3131279730 cites W2892325025 @default.
- W3131279730 cites W2910026377 @default.
- W3131279730 cites W2912441777 @default.
- W3131279730 cites W2937231989 @default.
- W3131279730 cites W2954662313 @default.
- W3131279730 cites W2955214382 @default.
- W3131279730 cites W2979284331 @default.
- W3131279730 cites W3012839625 @default.
- W3131279730 cites W4213088995 @default.
- W3131279730 doi "https://doi.org/10.1186/s12885-021-08616-8" @default.
- W3131279730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8344147" @default.
- W3131279730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34353313" @default.
- W3131279730 hasPublicationYear "2021" @default.
- W3131279730 type Work @default.
- W3131279730 sameAs 3131279730 @default.
- W3131279730 citedByCount "5" @default.
- W3131279730 countsByYear W31312797302022 @default.
- W3131279730 countsByYear W31312797302023 @default.
- W3131279730 crossrefType "journal-article" @default.
- W3131279730 hasAuthorship W3131279730A5005759601 @default.
- W3131279730 hasAuthorship W3131279730A5006207516 @default.
- W3131279730 hasAuthorship W3131279730A5023518824 @default.
- W3131279730 hasAuthorship W3131279730A5028243133 @default.
- W3131279730 hasAuthorship W3131279730A5037492199 @default.
- W3131279730 hasAuthorship W3131279730A5079331096 @default.
- W3131279730 hasAuthorship W3131279730A5079633934 @default.
- W3131279730 hasAuthorship W3131279730A5091138255 @default.
- W3131279730 hasBestOaLocation W31312797301 @default.
- W3131279730 hasConcept C104317684 @default.
- W3131279730 hasConcept C119056186 @default.
- W3131279730 hasConcept C173396325 @default.
- W3131279730 hasConcept C502942594 @default.
- W3131279730 hasConcept C54355233 @default.
- W3131279730 hasConcept C62112901 @default.
- W3131279730 hasConcept C71924100 @default.
- W3131279730 hasConcept C81885089 @default.
- W3131279730 hasConcept C86803240 @default.
- W3131279730 hasConceptScore W3131279730C104317684 @default.
- W3131279730 hasConceptScore W3131279730C119056186 @default.
- W3131279730 hasConceptScore W3131279730C173396325 @default.
- W3131279730 hasConceptScore W3131279730C502942594 @default.
- W3131279730 hasConceptScore W3131279730C54355233 @default.
- W3131279730 hasConceptScore W3131279730C62112901 @default.
- W3131279730 hasConceptScore W3131279730C71924100 @default.
- W3131279730 hasConceptScore W3131279730C81885089 @default.
- W3131279730 hasConceptScore W3131279730C86803240 @default.
- W3131279730 hasIssue "1" @default.
- W3131279730 hasLocation W31312797301 @default.
- W3131279730 hasLocation W31312797302 @default.
- W3131279730 hasLocation W31312797303 @default.
- W3131279730 hasLocation W31312797304 @default.
- W3131279730 hasOpenAccess W3131279730 @default.
- W3131279730 hasPrimaryLocation W31312797301 @default.
- W3131279730 hasRelatedWork W2039201715 @default.