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- W3131347508 abstract "A sensitive and highly reproducible cardiac troponin I (cTnI) immunoassay in human serum is a challenging research goal for researchers studying biosensors because cTnI can undergo proteolysis and various modifications in blood. Furthermore, the reproducible detection of cTnI at very low concentrations is also required for diagnosing acute myocardial infarction. Here, we present sensitive and highly reproducible quartz crystal microbalance (QCM) immunosensors for the detection of cTnI in human serum. The unique features of this study are the use of a pair of capture antibodies that bind to different epitopes of cTnI, and the use of a signal amplification technique that enlarged the size of the titanium dioxide nanoparticles using photocatalytic silver staining. Since QCM measures changes in the resonance frequency due to the changes in mass occurring on the sensor surface, it is possible to quantitatively analyze cTnI based on the enormous increase in mass using a sandwich immunoassay and subsequent signal amplification by silver staining. The detection limit of the cTnI immunoassay in human serum without photocatalytic silver staining was 307 pg/ml, but 18 pg/ml in photocatalytic silver staining-mediated signal amplification. Thus, amplifying the signal increased the sensitivity and reproducibility of the cTnI immunoassay in human serum." @default.
- W3131347508 created "2021-03-01" @default.
- W3131347508 creator A5022569990 @default.
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- W3131347508 date "2021-06-01" @default.
- W3131347508 modified "2023-09-26" @default.
- W3131347508 title "Quartz crystal microbalance cardiac Troponin I immunosensors employing signal amplification with TiO2 nanoparticle photocatalyst" @default.
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- W3131347508 doi "https://doi.org/10.1016/j.talanta.2021.122233" @default.
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