FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131349468> ?p ?o ?g. }

• W3131349468 abstract "Background: Previous neuroimaging studies have demonstrated brain abnormalities in patients with hepatic diseases. However, the identified liver–brain associations are largely limited to disease-affected populations, and the nature and extent of such relations in healthy subjects remain unclear. We hypothesized that serum liver function markers within a normal level would affect brain properties. Method: One hundred fifty-seven healthy young adults underwent structural, resting-state functional, and arterial spin labeling MRI scans. Gray matter volume (GMV), regional homogeneity (ReHo), and cerebral blood flow (CBF) analyses were performed to assess brain structure, function, and perfusion, respectively. Peripheral venous blood samples were collected to measure serum liver function markers. Correlation analyses were conducted to test potential associations between liver function markers and brain imaging parameters. Results: First, serum proteins showed relations to brain structure characterized by higher albumin associated with increased GMV in the parahippocampal gyrus and amygdala and lower globulin and a higher albumin/globulin ratio with increased GMV in the olfactory cortex and parahippocampal gyrus. Second, serum bilirubin was linked to brain function characterized by higher bilirubin associated with increased ReHo in the precuneus, middle cingulate gyrus, inferior parietal lobule, and supramarginal gyrus and decreased ReHo in the caudate nucleus. Third, serum alanine transaminase (ALT) was related to brain perfusion characterized by higher ALT associated with increased CBF in the superior frontal gyrus and decreased CBF in the middle occipital gyrus, angular gyrus, precuneus, and middle temporal gyrus. More importantly, we found that CBF in the superior frontal gyrus was a significant mediator of the association between serum ALT level and working memory performance. Conclusion: These findings may not only expand existing knowledge about the relationship between the liver and the brain but also have clinical implications for studying brain impairments secondary to liver diseases as well as providing potential neural targets for their diagnosis and treatment." @default.
• W3131349468 created "2021-03-01" @default.
• W3131349468 creator A5005431252 @default.
• W3131349468 creator A5007928549 @default.
• W3131349468 creator A5015356988 @default.
• W3131349468 creator A5046341550 @default.
• W3131349468 creator A5053204257 @default.
• W3131349468 creator A5057947122 @default.
• W3131349468 creator A5069553504 @default.
• W3131349468 creator A5074313030 @default.
• W3131349468 creator A5080790786 @default.
• W3131349468 creator A5084046764 @default.
• W3131349468 creator A5084888732 @default.
• W3131349468 date "2021-02-25" @default.
• W3131349468 modified "2023-10-15" @default.
• W3131349468 title "Associations of Serum Liver Function Markers With Brain Structure, Function, and Perfusion in Healthy Young Adults" @default.
• W3131349468 cites W1448960299 @default.
• W3131349468 cites W1530119605 @default.
• W3131349468 cites W1847258812 @default.
• W3131349468 cites W1964372920 @default.
• W3131349468 cites W1964860432 @default.
• W3131349468 cites W1966582616 @default.
• W3131349468 cites W1975181295 @default.
• W3131349468 cites W1981460639 @default.
• W3131349468 cites W1986706205 @default.
• W3131349468 cites W1989199068 @default.
• W3131349468 cites W1993174659 @default.
• W3131349468 cites W2000697043 @default.
• W3131349468 cites W2006957711 @default.
• W3131349468 cites W2007213925 @default.
• W3131349468 cites W2008754958 @default.
• W3131349468 cites W2016934176 @default.
• W3131349468 cites W2019930104 @default.
• W3131349468 cites W2031503422 @default.
• W3131349468 cites W2032404758 @default.
• W3131349468 cites W2039174593 @default.
• W3131349468 cites W2058046532 @default.
• W3131349468 cites W2062502161 @default.
• W3131349468 cites W2072409567 @default.
• W3131349468 cites W2074932610 @default.
• W3131349468 cites W2085989324 @default.
• W3131349468 cites W2087329261 @default.
• W3131349468 cites W2090533935 @default.
• W3131349468 cites W2103033985 @default.
• W3131349468 cites W2103650651 @default.
• W3131349468 cites W2107483470 @default.
• W3131349468 cites W2108050717 @default.
• W3131349468 cites W2114046308 @default.
• W3131349468 cites W2117693696 @default.
• W3131349468 cites W2119848633 @default.
• W3131349468 cites W2123179086 @default.
• W3131349468 cites W2125618313 @default.
• W3131349468 cites W2143323463 @default.
• W3131349468 cites W2153017955 @default.
• W3131349468 cites W2155298532 @default.
• W3131349468 cites W2158974830 @default.
• W3131349468 cites W2265176083 @default.
• W3131349468 cites W2286726515 @default.
• W3131349468 cites W2319898015 @default.
• W3131349468 cites W2337323496 @default.
• W3131349468 cites W2346987069 @default.
• W3131349468 cites W2351649139 @default.
• W3131349468 cites W2533675294 @default.
• W3131349468 cites W2537481264 @default.
• W3131349468 cites W2560163172 @default.
• W3131349468 cites W2560693837 @default.
• W3131349468 cites W2563118732 @default.
• W3131349468 cites W2564825033 @default.
• W3131349468 cites W2589870402 @default.
• W3131349468 cites W2616659710 @default.
• W3131349468 cites W2793313273 @default.
• W3131349468 cites W2887261499 @default.
• W3131349468 cites W2946821913 @default.
• W3131349468 cites W2951941597 @default.
• W3131349468 cites W2964054943 @default.
• W3131349468 cites W2964395205 @default.
• W3131349468 cites W2966029669 @default.
• W3131349468 cites W2971258849 @default.
• W3131349468 cites W2974320874 @default.
• W3131349468 cites W4210373601 @default.
• W3131349468 cites W4230920194 @default.
• W3131349468 cites W4247878364 @default.
• W3131349468 cites W4376848381 @default.
• W3131349468 doi "https://doi.org/10.3389/fneur.2021.606094" @default.
• W3131349468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7947675" @default.
• W3131349468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33716920" @default.
• W3131349468 hasPublicationYear "2021" @default.
• W3131349468 type Work @default.
• W3131349468 sameAs 3131349468 @default.
• W3131349468 citedByCount "6" @default.
• W3131349468 countsByYear W31313494682022 @default.
• W3131349468 countsByYear W31313494682023 @default.
• W3131349468 crossrefType "journal-article" @default.
• W3131349468 hasAuthorship W3131349468A5005431252 @default.
• W3131349468 hasAuthorship W3131349468A5007928549 @default.
• W3131349468 hasAuthorship W3131349468A5015356988 @default.
• W3131349468 hasAuthorship W3131349468A5046341550 @default.
• W3131349468 hasAuthorship W3131349468A5053204257 @default.
• W3131349468 hasAuthorship W3131349468A5057947122 @default.
• W3131349468 hasAuthorship W3131349468A5069553504 @default.

• next