FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131365592> ?p ?o ?g. }

• W3131365592 endingPage "519" @default.
• W3131365592 startingPage "510" @default.
• W3131365592 abstract "Checkpoint inhibitor-induced hepatitis is an immune-related adverse event of programmed cell death protein 1 (PD-1) inhibition, cytotoxic T-lymphocyte associated 4 (CTLA-4) inhibition or the combination of both. Aim of this study was to assess whether checkpoint inhibitor-induced hepatitis is related to liver metastasis and outcome in a real-world nationwide cohort.Data from the prospective nationwide Dutch Melanoma Treatment Registry (DMTR) was used to analyze incidence, risk factors of checkpoint inhibitor-induced grade 3-4 hepatitis and outcome.2561 advanced cutaneous melanoma patients received 3111 treatments with checkpoint inhibitors between May 2012 and January 2019. Severe hepatitis occurred in 30/1620 (1.8%) patients treated with PD-1 inhibitors, in 29/1105 (2.6%) patients treated with ipilimumab and in 80/386 (20.7%) patients treated with combination therapy. Patients with hepatitis had a similar prevalence of liver metastasis compared to patients without hepatitis (32% vs. 27%; p = 0.58 for PD-1 inhibitors; 42% vs. 29%; p = 0.16 for ipilimumab; 38% vs. 43%; p = 0.50 for combination therapy). There was no difference in median progression free and overall survival between patients with and without hepatitis (6.0 months vs. 5.4 months progression-free survival; p = 0.61; 17.0 vs. 16.2 months overall survival; p = 0.44).Incidence of hepatitis in a real-world cohort is 1.8% for PD-1 inhibitor, 2.6% for ipilimumab and 20.7% for combination therapy. Checkpoint inhibitor-induced hepatitis had no relation with liver metastasis and had no negative effect on the outcome." @default.
• W3131365592 created "2021-03-01" @default.
• W3131365592 creator A5000559108 @default.
• W3131365592 creator A5009376752 @default.
• W3131365592 creator A5012636605 @default.
• W3131365592 creator A5013384569 @default.
• W3131365592 creator A5013546961 @default.
• W3131365592 creator A5017136846 @default.
• W3131365592 creator A5019680927 @default.
• W3131365592 creator A5019881060 @default.
• W3131365592 creator A5024976681 @default.
• W3131365592 creator A5028034089 @default.
• W3131365592 creator A5031300611 @default.
• W3131365592 creator A5031506026 @default.
• W3131365592 creator A5043575344 @default.
• W3131365592 creator A5061860913 @default.
• W3131365592 creator A5066417924 @default.
• W3131365592 creator A5081011064 @default.
• W3131365592 creator A5087233004 @default.
• W3131365592 creator A5087767413 @default.
• W3131365592 date "2021-02-25" @default.
• W3131365592 modified "2023-10-08" @default.
• W3131365592 title "Checkpoint inhibitor induced hepatitis and the relation with liver metastasis and outcome in advanced melanoma patients" @default.
• W3131365592 cites W2022430110 @default.
• W3131365592 cites W2109653150 @default.
• W3131365592 cites W2112069616 @default.
• W3131365592 cites W2132916434 @default.
• W3131365592 cites W2166662937 @default.
• W3131365592 cites W2329871425 @default.
• W3131365592 cites W2529484692 @default.
• W3131365592 cites W2561799613 @default.
• W3131365592 cites W2599658522 @default.
• W3131365592 cites W2607272476 @default.
• W3131365592 cites W2736166064 @default.
• W3131365592 cites W2753432434 @default.
• W3131365592 cites W2754843476 @default.
• W3131365592 cites W2765836977 @default.
• W3131365592 cites W2775503072 @default.
• W3131365592 cites W2788726176 @default.
• W3131365592 cites W2798160602 @default.
• W3131365592 cites W2888030212 @default.
• W3131365592 cites W2890094811 @default.
• W3131365592 cites W2895318254 @default.
• W3131365592 cites W2903585288 @default.
• W3131365592 cites W2910286250 @default.
• W3131365592 cites W2939863421 @default.
• W3131365592 cites W2945661283 @default.
• W3131365592 cites W2946620483 @default.
• W3131365592 cites W2967350775 @default.
• W3131365592 cites W2980907934 @default.
• W3131365592 cites W2998900184 @default.
• W3131365592 cites W3003310139 @default.
• W3131365592 cites W3003593122 @default.
• W3131365592 cites W3043703771 @default.
• W3131365592 cites W3044563839 @default.
• W3131365592 cites W3092802874 @default.
• W3131365592 doi "https://doi.org/10.1007/s12072-021-10151-4" @default.
• W3131365592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8144142" @default.
• W3131365592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33634373" @default.
• W3131365592 hasPublicationYear "2021" @default.
• W3131365592 type Work @default.
• W3131365592 sameAs 3131365592 @default.
• W3131365592 citedByCount "13" @default.
• W3131365592 countsByYear W31313655922021 @default.
• W3131365592 countsByYear W31313655922022 @default.
• W3131365592 countsByYear W31313655922023 @default.
• W3131365592 crossrefType "journal-article" @default.
• W3131365592 hasAuthorship W3131365592A5000559108 @default.
• W3131365592 hasAuthorship W3131365592A5009376752 @default.
• W3131365592 hasAuthorship W3131365592A5012636605 @default.
• W3131365592 hasAuthorship W3131365592A5013384569 @default.
• W3131365592 hasAuthorship W3131365592A5013546961 @default.
• W3131365592 hasAuthorship W3131365592A5017136846 @default.
• W3131365592 hasAuthorship W3131365592A5019680927 @default.
• W3131365592 hasAuthorship W3131365592A5019881060 @default.
• W3131365592 hasAuthorship W3131365592A5024976681 @default.
• W3131365592 hasAuthorship W3131365592A5028034089 @default.
• W3131365592 hasAuthorship W3131365592A5031300611 @default.
• W3131365592 hasAuthorship W3131365592A5031506026 @default.
• W3131365592 hasAuthorship W3131365592A5043575344 @default.
• W3131365592 hasAuthorship W3131365592A5061860913 @default.
• W3131365592 hasAuthorship W3131365592A5066417924 @default.
• W3131365592 hasAuthorship W3131365592A5081011064 @default.
• W3131365592 hasAuthorship W3131365592A5087233004 @default.
• W3131365592 hasAuthorship W3131365592A5087767413 @default.
• W3131365592 hasBestOaLocation W31313655921 @default.
• W3131365592 hasConcept C121608353 @default.
• W3131365592 hasConcept C126322002 @default.
• W3131365592 hasConcept C143998085 @default.
• W3131365592 hasConcept C2776029263 @default.
• W3131365592 hasConcept C2776455275 @default.
• W3131365592 hasConcept C2776999253 @default.
• W3131365592 hasConcept C2777701055 @default.
• W3131365592 hasConcept C2779013556 @default.
• W3131365592 hasConcept C2781433595 @default.
• W3131365592 hasConcept C41260117 @default.
• W3131365592 hasConcept C71924100 @default.
• W3131365592 hasConcept C90924648 @default.

• next