FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131392010> ?p ?o ?g. }

• W3131392010 abstract "Objectives: While opioids temporarily alleviate pain, the overshoot of balancing pain drivers may increase pain, leading to opioid induced hyperalgesia (OIH). Our goal was to find out what chronic opioid treatment does to pain tolerance as measured by the cold pressor test (CPT), an objective measure of pain tolerance, and to find an alternative effective treatment for chronic pain and FM. Materials and Methods: The setting was an academic addiction medicine service that has an embedded pain service. Patients had routine clinical care starting with an evaluation that included assessment of medical and psychiatric conditions. Participants were 55 patients with OIH and 21 patients with fibromyalgia; all had at least two CPTs. Treatment included a single dose of buprenorphine for detoxification. In this open-label case series, patients were treated with low dose naltrexone (LDN), a pure opioid receptor antagonist that, we hypothesize, treats OIH and FM by restoring endogenous opioid tone. Results: Comparing initial and last CPT times, those with OIH more than quadrupled their pain tolerance, and those with FM doubled theirs. This improved pain tolerance for OIH and FM was statistically significant ( p &lt; 0.0001 and p = 0.003, respectively) and had a large effect size ( r = 0.82 and r = 0.63, respectively). Discussion: Results suggest that patients on chronic opioid therapy should have pain tolerance measured by CPT with detoxification and LDN provided to correct opioid induced hyperalgesia if found. FM may also be treated with LDN. The main limitation of the findings was lack of a randomized control group treated with placebo." @default.
• W3131392010 created "2021-03-01" @default.
• W3131392010 creator A5032088603 @default.
• W3131392010 creator A5052145058 @default.
• W3131392010 creator A5068866357 @default.
• W3131392010 creator A5070641331 @default.
• W3131392010 creator A5082399104 @default.
• W3131392010 date "2021-02-16" @default.
• W3131392010 modified "2023-09-27" @default.
• W3131392010 title "The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia" @default.
• W3131392010 cites W1532642006 @default.
• W3131392010 cites W1967056552 @default.
• W3131392010 cites W1967871273 @default.
• W3131392010 cites W1982655087 @default.
• W3131392010 cites W1991055198 @default.
• W3131392010 cites W1995317457 @default.
• W3131392010 cites W1996108093 @default.
• W3131392010 cites W1998993206 @default.
• W3131392010 cites W2002801929 @default.
• W3131392010 cites W2005703418 @default.
• W3131392010 cites W2013302461 @default.
• W3131392010 cites W2024836296 @default.
• W3131392010 cites W2025653942 @default.
• W3131392010 cites W2029584624 @default.
• W3131392010 cites W2031292802 @default.
• W3131392010 cites W2036976775 @default.
• W3131392010 cites W2040668587 @default.
• W3131392010 cites W2041358545 @default.
• W3131392010 cites W2045175240 @default.
• W3131392010 cites W2046217025 @default.
• W3131392010 cites W2047395646 @default.
• W3131392010 cites W2053355176 @default.
• W3131392010 cites W2055109038 @default.
• W3131392010 cites W2071281213 @default.
• W3131392010 cites W2071801806 @default.
• W3131392010 cites W2079957063 @default.
• W3131392010 cites W2084761932 @default.
• W3131392010 cites W2091235395 @default.
• W3131392010 cites W2096615733 @default.
• W3131392010 cites W2106315421 @default.
• W3131392010 cites W2108163830 @default.
• W3131392010 cites W2118014677 @default.
• W3131392010 cites W2123131795 @default.
• W3131392010 cites W2125295858 @default.
• W3131392010 cites W2126241051 @default.
• W3131392010 cites W2128243813 @default.
• W3131392010 cites W2132854289 @default.
• W3131392010 cites W2136216025 @default.
• W3131392010 cites W2137423237 @default.
• W3131392010 cites W2144286905 @default.
• W3131392010 cites W2144694293 @default.
• W3131392010 cites W2146549647 @default.
• W3131392010 cites W2154071856 @default.
• W3131392010 cites W2160820922 @default.
• W3131392010 cites W2169358051 @default.
• W3131392010 cites W2239029086 @default.
• W3131392010 cites W2253364553 @default.
• W3131392010 cites W2317320998 @default.
• W3131392010 cites W2344557031 @default.
• W3131392010 cites W2404283831 @default.
• W3131392010 cites W2412243856 @default.
• W3131392010 cites W2523270510 @default.
• W3131392010 cites W2592360091 @default.
• W3131392010 cites W2744385640 @default.
• W3131392010 cites W2801864057 @default.
• W3131392010 cites W2811135295 @default.
• W3131392010 cites W2891285073 @default.
• W3131392010 cites W2891868538 @default.
• W3131392010 cites W2900809123 @default.
• W3131392010 cites W2902566357 @default.
• W3131392010 cites W2904907169 @default.
• W3131392010 cites W2936841203 @default.
• W3131392010 cites W2949184225 @default.
• W3131392010 cites W2955506720 @default.
• W3131392010 cites W3000593677 @default.
• W3131392010 cites W3005304034 @default.
• W3131392010 cites W3007810039 @default.
• W3131392010 cites W4211038282 @default.
• W3131392010 cites W4248836814 @default.
• W3131392010 doi "https://doi.org/10.3389/fpsyt.2021.593842" @default.
• W3131392010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7921161" @default.
• W3131392010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33664680" @default.
• W3131392010 hasPublicationYear "2021" @default.
• W3131392010 type Work @default.
• W3131392010 sameAs 3131392010 @default.
• W3131392010 citedByCount "17" @default.
• W3131392010 countsByYear W31313920102021 @default.
• W3131392010 countsByYear W31313920102022 @default.
• W3131392010 countsByYear W31313920102023 @default.
• W3131392010 crossrefType "journal-article" @default.
• W3131392010 hasAuthorship W3131392010A5032088603 @default.
• W3131392010 hasAuthorship W3131392010A5052145058 @default.
• W3131392010 hasAuthorship W3131392010A5068866357 @default.
• W3131392010 hasAuthorship W3131392010A5070641331 @default.
• W3131392010 hasAuthorship W3131392010A5082399104 @default.
• W3131392010 hasBestOaLocation W31313920101 @default.
• W3131392010 hasConcept C126322002 @default.
• W3131392010 hasConcept C15490471 @default.
• W3131392010 hasConcept C170493617 @default.
• W3131392010 hasConcept C1862650 @default.

• next