Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131415992> ?p ?o ?g. }
- W3131415992 abstract "Experimental and epidemiologic studies have shown that lead (Pb) is able to induce epigenetic modifications, such as changes in DNA methylation profiles, in chromatin remodeling, as well as the expression of non-coding RNAs (ncRNAs). However, very little is known about the interactions between microRNAs (miRNAs) expression and DNA methylation status in individuals exposed to the metal. The aim of the present study was to investigate the impact of hsa-miR-148a expression on DNA methylation status, in 85 workers exposed to Pb. Blood and plasma lead levels (BLL and PLL, respectively) were determined by ICP-MS; expression of the miRNA-148a was quantified by RT-qPCR (TaqMan assay) and assessment of the global DNA methylation profile (by measurement of 5-methylcytosine; % 5-mC) was performed by ELISA. An inverse association was seen between miR-148a and % 5-mC DNA, as a function of BLL and PLL (β = −3.7; p = 0.071 and β = −4.1; p = 0.049, respectively) adjusted for age, BMI, smoking, and alcohol consumption. Taken together, our study provides further evidence concerning the interactions between DNA methylation profile and miR-148a, in individuals exposed to Pb." @default.
- W3131415992 created "2021-03-01" @default.
- W3131415992 creator A5001352991 @default.
- W3131415992 creator A5014255998 @default.
- W3131415992 creator A5019358446 @default.
- W3131415992 creator A5021227224 @default.
- W3131415992 creator A5040154841 @default.
- W3131415992 creator A5050319678 @default.
- W3131415992 creator A5062893599 @default.
- W3131415992 creator A5064892868 @default.
- W3131415992 creator A5065499462 @default.
- W3131415992 creator A5067971882 @default.
- W3131415992 creator A5075385950 @default.
- W3131415992 creator A5082107048 @default.
- W3131415992 date "2021-02-17" @default.
- W3131415992 modified "2023-10-17" @default.
- W3131415992 title "Association Between miR-148a and DNA Methylation Profile in Individuals Exposed to Lead (Pb)" @default.
- W3131415992 cites W1792229149 @default.
- W3131415992 cites W1883623951 @default.
- W3131415992 cites W1970547929 @default.
- W3131415992 cites W1986316823 @default.
- W3131415992 cites W2010927970 @default.
- W3131415992 cites W2020021494 @default.
- W3131415992 cites W2027667548 @default.
- W3131415992 cites W2049253515 @default.
- W3131415992 cites W2050640053 @default.
- W3131415992 cites W2052528421 @default.
- W3131415992 cites W2054239157 @default.
- W3131415992 cites W2062998888 @default.
- W3131415992 cites W2064885200 @default.
- W3131415992 cites W2069046566 @default.
- W3131415992 cites W2076329264 @default.
- W3131415992 cites W2083248581 @default.
- W3131415992 cites W2085894535 @default.
- W3131415992 cites W2088501324 @default.
- W3131415992 cites W2094262752 @default.
- W3131415992 cites W2105686255 @default.
- W3131415992 cites W2110119545 @default.
- W3131415992 cites W2135584521 @default.
- W3131415992 cites W2146003771 @default.
- W3131415992 cites W2148506810 @default.
- W3131415992 cites W2152656267 @default.
- W3131415992 cites W2160998038 @default.
- W3131415992 cites W2335883384 @default.
- W3131415992 cites W2397261724 @default.
- W3131415992 cites W2460309748 @default.
- W3131415992 cites W2558053133 @default.
- W3131415992 cites W2592579739 @default.
- W3131415992 cites W2616222401 @default.
- W3131415992 cites W2750801521 @default.
- W3131415992 cites W2755799567 @default.
- W3131415992 cites W2789662105 @default.
- W3131415992 cites W2793930252 @default.
- W3131415992 cites W2794612153 @default.
- W3131415992 cites W2804245577 @default.
- W3131415992 cites W2910928884 @default.
- W3131415992 cites W2911555486 @default.
- W3131415992 cites W2911900065 @default.
- W3131415992 cites W2934806320 @default.
- W3131415992 cites W2944140566 @default.
- W3131415992 cites W2945472035 @default.
- W3131415992 cites W2946459356 @default.
- W3131415992 cites W2965431572 @default.
- W3131415992 cites W3001041847 @default.
- W3131415992 cites W3007209165 @default.
- W3131415992 cites W3015870489 @default.
- W3131415992 cites W3027162744 @default.
- W3131415992 doi "https://doi.org/10.3389/fgene.2021.620744" @default.
- W3131415992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7928366" @default.
- W3131415992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33679885" @default.
- W3131415992 hasPublicationYear "2021" @default.
- W3131415992 type Work @default.
- W3131415992 sameAs 3131415992 @default.
- W3131415992 citedByCount "10" @default.
- W3131415992 countsByYear W31314159922021 @default.
- W3131415992 countsByYear W31314159922022 @default.
- W3131415992 countsByYear W31314159922023 @default.
- W3131415992 crossrefType "journal-article" @default.
- W3131415992 hasAuthorship W3131415992A5001352991 @default.
- W3131415992 hasAuthorship W3131415992A5014255998 @default.
- W3131415992 hasAuthorship W3131415992A5019358446 @default.
- W3131415992 hasAuthorship W3131415992A5021227224 @default.
- W3131415992 hasAuthorship W3131415992A5040154841 @default.
- W3131415992 hasAuthorship W3131415992A5050319678 @default.
- W3131415992 hasAuthorship W3131415992A5062893599 @default.
- W3131415992 hasAuthorship W3131415992A5064892868 @default.
- W3131415992 hasAuthorship W3131415992A5065499462 @default.
- W3131415992 hasAuthorship W3131415992A5067971882 @default.
- W3131415992 hasAuthorship W3131415992A5075385950 @default.
- W3131415992 hasAuthorship W3131415992A5082107048 @default.
- W3131415992 hasBestOaLocation W31314159921 @default.
- W3131415992 hasConcept C104317684 @default.
- W3131415992 hasConcept C143660080 @default.
- W3131415992 hasConcept C145059251 @default.
- W3131415992 hasConcept C150194340 @default.
- W3131415992 hasConcept C153911025 @default.
- W3131415992 hasConcept C154253233 @default.
- W3131415992 hasConcept C190727270 @default.
- W3131415992 hasConcept C33288867 @default.
- W3131415992 hasConcept C41091548 @default.