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- W3131425072 abstract "The emergence of novel doping agents is a continuous issue for analysts who aim to maintain the integrity of horseracing together with the well-being and safety of the animals and riders involved. Untargeted mass spectrometric analysis presents a potential improvement for antidoping as it enables the detection of compounds being indirectly affected by an administered drug. In this study, liquid chromatography-high-resolution mass spectrometry was used to investigate a 12-horse administration study of the synthetic opioid, butorphanol. A mass spectrometric workflow capable of detecting metabolic differences for an extended period of time was successfully developed. This proof-of-concept study demonstrates the potential of untargeted workflows to provide a list of biomarkers of exposure and effect that are indicative of drug administration which may be implemented into routine testing for improved doping control." @default.
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- W3131425072 date "2021-03-03" @default.
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- W3131425072 title "Towards an untargeted mass spectrometric approach for improved screening in equine antidoping" @default.
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- W3131425072 doi "https://doi.org/10.1002/dta.3021" @default.
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