FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131435265> ?p ?o ?g. }

• W3131435265 endingPage "1200" @default.
• W3131435265 startingPage "1200" @default.
• W3131435265 abstract "Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged to be the greatest threat to humanity in the modern world and has claimed nearly 2.2 million lives worldwide. The United States alone accounts for more than one fourth of 100 million COVID-19 cases across the globe. Although vaccination against SARS-CoV-2 has begun, its efficacy in preventing a new or repeat COVID-19 infection in immunized individuals is yet to be determined. Calls for repurposing of existing, approved, drugs that target the inflammatory condition in COVID-19 are growing. Our initial gene ontology analysis predicts a similarity between SARS-CoV-2 induced inflammatory and immune dysregulation and the pathophysiology of rheumatoid arthritis. Interestingly, many of the drugs related to rheumatoid arthritis have been found to be lifesaving and contribute to lower COVID-19 morbidity. We also performed in silico investigation of binding of epigallocatechin gallate (EGCG), a well-known catechin, and other catechins on viral proteins and identified papain-like protease protein (PLPro) as a binding partner. Catechins bind to the S1 ubiquitin-binding site of PLPro, which might inhibit its protease function and abrogate SARS-CoV-2 inhibitory function on ubiquitin proteasome system and interferon stimulated gene system. In the realms of addressing inflammation and how to effectively target SARS-CoV-2 mediated respiratory distress syndrome, we review in this article the available knowledge on the strategic placement of EGCG in curbing inflammatory signals and how it may serve as a broad spectrum therapeutic in asymptomatic and symptomatic COVID-19 patients." @default.
• W3131435265 created "2021-03-01" @default.
• W3131435265 creator A5006912465 @default.
• W3131435265 creator A5015471468 @default.
• W3131435265 creator A5050722674 @default.
• W3131435265 creator A5062071336 @default.
• W3131435265 creator A5081086800 @default.
• W3131435265 date "2021-02-24" @default.
• W3131435265 modified "2023-09-26" @default.
• W3131435265 title "EGCG, a Green Tea Catechin, as a Potential Therapeutic Agent for Symptomatic and Asymptomatic SARS-CoV-2 Infection" @default.
• W3131435265 cites W1704599202 @default.
• W3131435265 cites W1831152517 @default.
• W3131435265 cites W1837453255 @default.
• W3131435265 cites W1968906564 @default.
• W3131435265 cites W1974486772 @default.
• W3131435265 cites W1983247237 @default.
• W3131435265 cites W1989207797 @default.
• W3131435265 cites W1992482172 @default.
• W3131435265 cites W1993154118 @default.
• W3131435265 cites W2024031999 @default.
• W3131435265 cites W2028244585 @default.
• W3131435265 cites W2028394765 @default.
• W3131435265 cites W2028563607 @default.
• W3131435265 cites W2032072939 @default.
• W3131435265 cites W2033313710 @default.
• W3131435265 cites W2040463885 @default.
• W3131435265 cites W2047416003 @default.
• W3131435265 cites W2054223388 @default.
• W3131435265 cites W2064292506 @default.
• W3131435265 cites W2070755485 @default.
• W3131435265 cites W2081270026 @default.
• W3131435265 cites W2088943364 @default.
• W3131435265 cites W2093851531 @default.
• W3131435265 cites W2096547375 @default.
• W3131435265 cites W2099489843 @default.
• W3131435265 cites W2102377211 @default.
• W3131435265 cites W2105828029 @default.
• W3131435265 cites W2113560985 @default.
• W3131435265 cites W2116207286 @default.
• W3131435265 cites W2132099454 @default.
• W3131435265 cites W2134168236 @default.
• W3131435265 cites W2137647018 @default.
• W3131435265 cites W2148779163 @default.
• W3131435265 cites W2222589778 @default.
• W3131435265 cites W2273866001 @default.
• W3131435265 cites W2295608765 @default.
• W3131435265 cites W2408652949 @default.
• W3131435265 cites W2472177135 @default.
• W3131435265 cites W2616508022 @default.
• W3131435265 cites W2734657018 @default.
• W3131435265 cites W2741311689 @default.
• W3131435265 cites W2752514371 @default.
• W3131435265 cites W2770598298 @default.
• W3131435265 cites W2791128717 @default.
• W3131435265 cites W2791337022 @default.
• W3131435265 cites W2804802143 @default.
• W3131435265 cites W2884639870 @default.
• W3131435265 cites W2887043640 @default.
• W3131435265 cites W2893222242 @default.
• W3131435265 cites W2941926545 @default.
• W3131435265 cites W2966141361 @default.
• W3131435265 cites W2972820581 @default.
• W3131435265 cites W3007268848 @default.
• W3131435265 cites W3012421327 @default.
• W3131435265 cites W3015463909 @default.
• W3131435265 cites W3016171365 @default.
• W3131435265 cites W3018517500 @default.
• W3131435265 cites W3023982717 @default.
• W3131435265 cites W3024307630 @default.
• W3131435265 cites W3026301261 @default.
• W3131435265 cites W3026876115 @default.
• W3131435265 cites W3027918021 @default.
• W3131435265 cites W3034328076 @default.
• W3131435265 cites W3036280377 @default.
• W3131435265 cites W3036931136 @default.
• W3131435265 cites W3038063455 @default.
• W3131435265 cites W3038607673 @default.
• W3131435265 cites W3041667892 @default.
• W3131435265 cites W3046218096 @default.
• W3131435265 cites W3046588153 @default.
• W3131435265 cites W3047782160 @default.
• W3131435265 cites W3048128444 @default.
• W3131435265 cites W3048530683 @default.
• W3131435265 cites W3080855264 @default.
• W3131435265 cites W3083872269 @default.
• W3131435265 cites W3090786066 @default.
• W3131435265 cites W3093604087 @default.
• W3131435265 cites W3102488036 @default.
• W3131435265 cites W3112902030 @default.
• W3131435265 cites W3119453605 @default.
• W3131435265 cites W3125094078 @default.
• W3131435265 cites W4205483821 @default.
• W3131435265 doi "https://doi.org/10.3390/molecules26051200" @default.
• W3131435265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7956763" @default.
• W3131435265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33668085" @default.
• W3131435265 hasPublicationYear "2021" @default.
• W3131435265 type Work @default.
• W3131435265 sameAs 3131435265 @default.

• next