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- W3131453240 endingPage "1706" @default.
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- W3131453240 abstract "Wnt/β-catenin signaling is indispensable for many biological processes, including embryonic development, cell cycle, inflammation, and carcinogenesis. Aberrant activation of the Wnt/β-catenin signaling can promote tumorigenicity and enhance metastatic potential in hepatocellular carcinoma (HCC). Targeting this pathway is a new opportunity for precise medicine for HCC. However, inhibiting Wnt/β-catenin signaling alone is unlikely to significantly improve HCC patient outcome due to the lack of specific inhibitors and the complexity of this pathway. Combination with other therapies will be an important next step in improving the efficacy of Wnt/β-catenin signaling inhibitors. Protein kinases play a key and evolutionarily conserved role in the Wnt/β-catenin signaling and have become one of the most important drug targets in cancer. Targeting Wnt/β-catenin signaling and its regulatory kinase together will be a promising HCC management strategy. In this review, we summarize the kinases that modulate the Wnt/β-catenin signaling in HCC and briefly discuss their molecular mechanisms. Furthermore, we list some small molecules that target the kinases and may inhibit Wnt/β-catenin signaling, to offer new perspectives for preclinical and clinical HCC studies." @default.
- W3131453240 created "2021-03-01" @default.
- W3131453240 creator A5001578547 @default.
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- W3131453240 creator A5075373893 @default.
- W3131453240 creator A5080177170 @default.
- W3131453240 date "2021-04-06" @default.
- W3131453240 modified "2023-10-18" @default.
- W3131453240 title "Dysregulation of Wnt/β‐catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application" @default.
- W3131453240 cites W1902804987 @default.
- W3131453240 cites W1902879109 @default.
- W3131453240 cites W1966093262 @default.
- W3131453240 cites W1971085650 @default.
- W3131453240 cites W1974441369 @default.
- W3131453240 cites W1982194496 @default.
- W3131453240 cites W1994928797 @default.
- W3131453240 cites W2002506557 @default.
- W3131453240 cites W2003637983 @default.
- W3131453240 cites W2003979913 @default.
- W3131453240 cites W2008221746 @default.
- W3131453240 cites W2009684443 @default.
- W3131453240 cites W2017862163 @default.
- W3131453240 cites W2020903392 @default.
- W3131453240 cites W2028415754 @default.
- W3131453240 cites W2029437539 @default.
- W3131453240 cites W2034270890 @default.
- W3131453240 cites W2040942754 @default.
- W3131453240 cites W2044423100 @default.
- W3131453240 cites W2049350180 @default.
- W3131453240 cites W2049737165 @default.
- W3131453240 cites W2051882112 @default.
- W3131453240 cites W2055049583 @default.
- W3131453240 cites W2058056564 @default.
- W3131453240 cites W2059675569 @default.
- W3131453240 cites W2065088072 @default.
- W3131453240 cites W2065431388 @default.
- W3131453240 cites W2065864607 @default.
- W3131453240 cites W2071368342 @default.
- W3131453240 cites W2075152619 @default.
- W3131453240 cites W2077804275 @default.
- W3131453240 cites W2082387343 @default.
- W3131453240 cites W2087703581 @default.
- W3131453240 cites W2088938650 @default.
- W3131453240 cites W2092855542 @default.
- W3131453240 cites W2100945326 @default.
- W3131453240 cites W2104669784 @default.
- W3131453240 cites W2107648723 @default.
- W3131453240 cites W2107763333 @default.
- W3131453240 cites W2108689588 @default.
- W3131453240 cites W2109955944 @default.
- W3131453240 cites W2114594254 @default.
- W3131453240 cites W2117014232 @default.
- W3131453240 cites W2117330555 @default.
- W3131453240 cites W2119284420 @default.
- W3131453240 cites W2127407977 @default.
- W3131453240 cites W2136828732 @default.
- W3131453240 cites W2140642045 @default.
- W3131453240 cites W2147710756 @default.
- W3131453240 cites W2153173735 @default.
- W3131453240 cites W2160003033 @default.
- W3131453240 cites W2160318185 @default.
- W3131453240 cites W2163532069 @default.
- W3131453240 cites W2164193415 @default.
- W3131453240 cites W2165395478 @default.
- W3131453240 cites W2166805606 @default.
- W3131453240 cites W2170259414 @default.
- W3131453240 cites W2172909928 @default.
- W3131453240 cites W2180812884 @default.
- W3131453240 cites W2215047099 @default.
- W3131453240 cites W2226087335 @default.
- W3131453240 cites W2257956371 @default.
- W3131453240 cites W2278107767 @default.
- W3131453240 cites W2292650015 @default.
- W3131453240 cites W2320567491 @default.
- W3131453240 cites W2320687212 @default.
- W3131453240 cites W2407627822 @default.
- W3131453240 cites W2483520776 @default.
- W3131453240 cites W2486397717 @default.
- W3131453240 cites W2497652476 @default.
- W3131453240 cites W2512950521 @default.
- W3131453240 cites W2557640421 @default.
- W3131453240 cites W2581414232 @default.
- W3131453240 cites W2621361823 @default.
- W3131453240 cites W2623105769 @default.
- W3131453240 cites W2625649383 @default.
- W3131453240 cites W2750691704 @default.
- W3131453240 cites W2763178964 @default.
- W3131453240 cites W2783232491 @default.
- W3131453240 cites W2794211762 @default.
- W3131453240 cites W2794930605 @default.
- W3131453240 cites W2883204623 @default.